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Effects of early gestation GH administration on placental and fetal development in sheep.
J Endocrinol. 2008 Jul; 198(1):91-9.JE

Abstract

Ovine GH (oGH) is synthesized in placental tissue during maximal placental growth and development. Our objectives were to localize oGH mRNA in the placenta, and study the impact of exogenous GH on twin pregnancies during the normal window (35-55 days of gestational age; dGA) of placental expression. In situ hybridization localized oGH mRNA in uterine luminal epithelium but not in tissues of fetal origin. While maternal GH and IGF-I concentrations were increased (P<0.001) approximately tenfold, uterine, uterine fluid, placental, and fetal weights were unaffected by treatment at either 55 or 135 dGA. Fetal length, liver weight, and liver weight per kg of body weight were unaffected by maternal GH treatment. However, in the cotyledon, IGF-binding protein (BP)-1 and IGFBP-4 mRNA concentrations were increased (P<0.05), while IGFBP-2 mRNA was decreased (P<0.05). The concentration of mRNA for IGFBP-3 was unaffected by treatment. Within the caruncle, IGFBP-1 mRNA was decreased (P<0.05), while IGFBP-3 and IGFBP-4 mRNA were increased (P<0.05), and IGFBP-2 mRNA was unchanged due to GH treatment. While our data indicate that elevated maternal GH and IGF-I concentrations during early and mid-gestation do not enhance placental and fetal growth in twin pregnancies, localization of GH mRNA in uterine luminal epithelium could explain GHs transitory expression from 35 to 55 dGA, since by the end of this period the majority of the uterine luminal epithelium has fused with chorionic binucleate cells forming the placental syncytium.

Authors+Show Affiliations

Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, ARBL-Foothills Campus, Campus Delivery 1683, Fort Collins, Colorado 80-523-1683, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18430766

Citation

Wright, Casey D., et al. "Effects of Early Gestation GH Administration On Placental and Fetal Development in Sheep." The Journal of Endocrinology, vol. 198, no. 1, 2008, pp. 91-9.
Wright CD, Orbus RJ, Regnault TR, et al. Effects of early gestation GH administration on placental and fetal development in sheep. J Endocrinol. 2008;198(1):91-9.
Wright, C. D., Orbus, R. J., Regnault, T. R., & Anthony, R. V. (2008). Effects of early gestation GH administration on placental and fetal development in sheep. The Journal of Endocrinology, 198(1), 91-9. https://doi.org/10.1677/JOE-07-0481
Wright CD, et al. Effects of Early Gestation GH Administration On Placental and Fetal Development in Sheep. J Endocrinol. 2008;198(1):91-9. PubMed PMID: 18430766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of early gestation GH administration on placental and fetal development in sheep. AU - Wright,Casey D, AU - Orbus,Ryan J, AU - Regnault,Timothy R H, AU - Anthony,Russell V, Y1 - 2008/04/22/ PY - 2008/4/24/pubmed PY - 2009/7/8/medline PY - 2008/4/24/entrez SP - 91 EP - 9 JF - The Journal of endocrinology JO - J. Endocrinol. VL - 198 IS - 1 N2 - Ovine GH (oGH) is synthesized in placental tissue during maximal placental growth and development. Our objectives were to localize oGH mRNA in the placenta, and study the impact of exogenous GH on twin pregnancies during the normal window (35-55 days of gestational age; dGA) of placental expression. In situ hybridization localized oGH mRNA in uterine luminal epithelium but not in tissues of fetal origin. While maternal GH and IGF-I concentrations were increased (P<0.001) approximately tenfold, uterine, uterine fluid, placental, and fetal weights were unaffected by treatment at either 55 or 135 dGA. Fetal length, liver weight, and liver weight per kg of body weight were unaffected by maternal GH treatment. However, in the cotyledon, IGF-binding protein (BP)-1 and IGFBP-4 mRNA concentrations were increased (P<0.05), while IGFBP-2 mRNA was decreased (P<0.05). The concentration of mRNA for IGFBP-3 was unaffected by treatment. Within the caruncle, IGFBP-1 mRNA was decreased (P<0.05), while IGFBP-3 and IGFBP-4 mRNA were increased (P<0.05), and IGFBP-2 mRNA was unchanged due to GH treatment. While our data indicate that elevated maternal GH and IGF-I concentrations during early and mid-gestation do not enhance placental and fetal growth in twin pregnancies, localization of GH mRNA in uterine luminal epithelium could explain GHs transitory expression from 35 to 55 dGA, since by the end of this period the majority of the uterine luminal epithelium has fused with chorionic binucleate cells forming the placental syncytium. SN - 1479-6805 UR - https://www.unboundmedicine.com/medline/citation/18430766/Effects_of_early_gestation_GH_administration_on_placental_and_fetal_development_in_sheep_ L2 - https://joe.bioscientifica.com/doi/10.1677/JOE-07-0481 DB - PRIME DP - Unbound Medicine ER -