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Celiac disease: what's new about it?
Dig Dis 2008; 26(2):121-7DD

Abstract

In the present review we will try to summarize the clinical and diagnostic features of celiac disease (CD) as well as the new findings on extraintestinal manifestation. CD is an immune-mediated enteropathy caused by a permanent gluten intolerance. In the last years, the diagnosis is becoming more and more frequent because of the recognition of 'new' symptoms and associated extraintestinal manifestations. Classical CD is dominated by symptoms and sequelae of gastrointestinal malabsorption. In the 'atypical forms', the extraintestinal features usually predominate, with few or no gastrointestinal symptoms. Silent CD refers to asymptomatic patients with a positive serologic test and villous atrophy on biopsy. This form is detected by screening of high-risk individuals, or villous atrophy occasionally may be detected by endoscopy and biopsy conducted for another reason. The potential form is diagnosed in groups at risk including relatives of celiac patients, Down syndrome and autoimmune diseases. Latent CD is defined by positive serological tests but not histological changes on biopsy. These individuals are asymptomatic, but later may develop symptoms and/or histological alterations. Recognition of atypical manifestations of CD is very important because many cases can remain undiagnosed with an increased risk of long-term complications.

Authors+Show Affiliations

Department of Internal Medicine, Catholic University of Rome, Rome, Italy. ggasbarrini@rm.unicatt.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18431061

Citation

Gasbarrini, Giovanni, et al. "Celiac Disease: What's New About It?" Digestive Diseases (Basel, Switzerland), vol. 26, no. 2, 2008, pp. 121-7.
Gasbarrini G, Malandrino N, Giorgio V, et al. Celiac disease: what's new about it? Dig Dis. 2008;26(2):121-7.
Gasbarrini, G., Malandrino, N., Giorgio, V., Fundarò, C., Cammarota, G., Merra, G., ... Capristo, E. (2008). Celiac disease: what's new about it? Digestive Diseases (Basel, Switzerland), 26(2), pp. 121-7. doi:10.1159/000116769.
Gasbarrini G, et al. Celiac Disease: What's New About It. Dig Dis. 2008;26(2):121-7. PubMed PMID: 18431061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Celiac disease: what's new about it? AU - Gasbarrini,Giovanni, AU - Malandrino,Noemi, AU - Giorgio,Valentina, AU - Fundarò,Carlo, AU - Cammarota,Giovanni, AU - Merra,Giuseppe, AU - Roccarina,Davide, AU - Gasbarrini,Antonio, AU - Capristo,Esmeralda, Y1 - 2008/04/21/ PY - 2008/4/24/pubmed PY - 2008/6/21/medline PY - 2008/4/24/entrez SP - 121 EP - 7 JF - Digestive diseases (Basel, Switzerland) JO - Dig Dis VL - 26 IS - 2 N2 - In the present review we will try to summarize the clinical and diagnostic features of celiac disease (CD) as well as the new findings on extraintestinal manifestation. CD is an immune-mediated enteropathy caused by a permanent gluten intolerance. In the last years, the diagnosis is becoming more and more frequent because of the recognition of 'new' symptoms and associated extraintestinal manifestations. Classical CD is dominated by symptoms and sequelae of gastrointestinal malabsorption. In the 'atypical forms', the extraintestinal features usually predominate, with few or no gastrointestinal symptoms. Silent CD refers to asymptomatic patients with a positive serologic test and villous atrophy on biopsy. This form is detected by screening of high-risk individuals, or villous atrophy occasionally may be detected by endoscopy and biopsy conducted for another reason. The potential form is diagnosed in groups at risk including relatives of celiac patients, Down syndrome and autoimmune diseases. Latent CD is defined by positive serological tests but not histological changes on biopsy. These individuals are asymptomatic, but later may develop symptoms and/or histological alterations. Recognition of atypical manifestations of CD is very important because many cases can remain undiagnosed with an increased risk of long-term complications. SN - 1421-9875 UR - https://www.unboundmedicine.com/medline/citation/18431061/Celiac_disease:_what's_new_about_it L2 - https://www.karger.com?DOI=10.1159/000116769 DB - PRIME DP - Unbound Medicine ER -