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Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population.
Nat Clin Pract Cardiovasc Med. 2008 Jul; 5(7):418-25.NC

Abstract

BACKGROUND

Leptin could be a key regulator of C-reactive protein (CRP) levels, which serve as a marker of systemic inflammation. Both leptin and CRP are predictors of cardiovascular disease (CVD). However, the interactions between leptin and CRP, and their association with CVD, remain unclear. We therefore studied them in a large, multiethnic population.

METHODS

We analyzed leptin and CRP levels, anthropometric variables and cardiovascular risk factor data from 6,251 participants from the Third National Health and Nutrition Examination Survey (NHANES III). Logistic regression was used to estimate the association between leptin, CRP and CVD (defined as history of myocardial infarction or stroke). Receiver operating characteristic curves were created to study the additional value of leptin and CRP for the association with CVD.

RESULTS

The mean age was 44.4 +/- 0.21 years (52.5% women). After adjustment for age, race, dyslipidemia, hypertension, diabetes, smoking, obesity and CRP, high levels of leptin were significantly associated with CVD in men (odds ratio 2.47, 95% CI 1.19-5.19) and in women (odds ratio 3.30, 95% CI 1.47-7.99). After adjustment for leptin, CRP was not associated with CVD. There was a significant correlation between levels of leptin and CRP (Spearman correlation rho = 0.22 in men and rho = 0.32 in women, both P < 0.0001). The area under the curve, representing the association between cardiovascular risk factors and CVD, increased after the addition of high levels of both leptin and CRP together.

CONCLUSION

High leptin levels are independently associated with CVD even after adjustment for CRP; elevated CRP levels are not associated with CVD after adjustment for leptin. However, increased concentrations of both leptin and CRP confer the highest risk for CVD.

Authors+Show Affiliations

Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18431365

Citation

Romero-Corral, Abel, et al. "Relationships Between Leptin and C-reactive Protein With Cardiovascular Disease in the Adult General Population." Nature Clinical Practice. Cardiovascular Medicine, vol. 5, no. 7, 2008, pp. 418-25.
Romero-Corral A, Sierra-Johnson J, Lopez-Jimenez F, et al. Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population. Nat Clin Pract Cardiovasc Med. 2008;5(7):418-25.
Romero-Corral, A., Sierra-Johnson, J., Lopez-Jimenez, F., Thomas, R. J., Singh, P., Hoffmann, M., Okcay, A., Korinek, J., Wolk, R., & Somers, V. K. (2008). Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population. Nature Clinical Practice. Cardiovascular Medicine, 5(7), 418-25. https://doi.org/10.1038/ncpcardio1218
Romero-Corral A, et al. Relationships Between Leptin and C-reactive Protein With Cardiovascular Disease in the Adult General Population. Nat Clin Pract Cardiovasc Med. 2008;5(7):418-25. PubMed PMID: 18431365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population. AU - Romero-Corral,Abel, AU - Sierra-Johnson,Justo, AU - Lopez-Jimenez,Francisco, AU - Thomas,Randal J, AU - Singh,Prachi, AU - Hoffmann,Michal, AU - Okcay,Aynur, AU - Korinek,Josef, AU - Wolk,Robert, AU - Somers,Virend K, Y1 - 2008/04/22/ PY - 2007/12/03/received PY - 2008/03/04/accepted PY - 2008/4/24/pubmed PY - 2008/8/1/medline PY - 2008/4/24/entrez SP - 418 EP - 25 JF - Nature clinical practice. Cardiovascular medicine JO - Nat Clin Pract Cardiovasc Med VL - 5 IS - 7 N2 - BACKGROUND: Leptin could be a key regulator of C-reactive protein (CRP) levels, which serve as a marker of systemic inflammation. Both leptin and CRP are predictors of cardiovascular disease (CVD). However, the interactions between leptin and CRP, and their association with CVD, remain unclear. We therefore studied them in a large, multiethnic population. METHODS: We analyzed leptin and CRP levels, anthropometric variables and cardiovascular risk factor data from 6,251 participants from the Third National Health and Nutrition Examination Survey (NHANES III). Logistic regression was used to estimate the association between leptin, CRP and CVD (defined as history of myocardial infarction or stroke). Receiver operating characteristic curves were created to study the additional value of leptin and CRP for the association with CVD. RESULTS: The mean age was 44.4 +/- 0.21 years (52.5% women). After adjustment for age, race, dyslipidemia, hypertension, diabetes, smoking, obesity and CRP, high levels of leptin were significantly associated with CVD in men (odds ratio 2.47, 95% CI 1.19-5.19) and in women (odds ratio 3.30, 95% CI 1.47-7.99). After adjustment for leptin, CRP was not associated with CVD. There was a significant correlation between levels of leptin and CRP (Spearman correlation rho = 0.22 in men and rho = 0.32 in women, both P < 0.0001). The area under the curve, representing the association between cardiovascular risk factors and CVD, increased after the addition of high levels of both leptin and CRP together. CONCLUSION: High leptin levels are independently associated with CVD even after adjustment for CRP; elevated CRP levels are not associated with CVD after adjustment for leptin. However, increased concentrations of both leptin and CRP confer the highest risk for CVD. SN - 1743-4300 UR - https://www.unboundmedicine.com/medline/citation/18431365/Relationships_between_leptin_and_C_reactive_protein_with_cardiovascular_disease_in_the_adult_general_population_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=18431365.ui DB - PRIME DP - Unbound Medicine ER -