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Effect of particle size on compaction of materials with different deformation mechanisms with and without lubricants.
AAPS PharmSciTech. 2008; 9(2):414-8.AP

Abstract

This work investigates the effect of excipient particle size on compaction properties of brittle, plastic and viscoelastic materials with and without added lubricants. Sieve cuts of microcrystalline cellulose (MCC), starch and dibasic calcium phosphate dihydrate were obtained by sieving, then samples were tested without lubrication or with added lubricant (0.5% Mg stearate mixed for either 5 or 30-min). Compacts were left overnight before testing. It was found that in the absence of lubricant, compact tensile strength (TS) was dependent on particle size only for starch. With Mg stearate, lubricant sensitivity shows a strong dependence on excipient particle size for both starch and MCC, where smaller particles are less affected by lubricant. Dibasic calcium phosphate dihydrate was not sensitive to lubricant even after 30 min mixing. This study highlights that in the absence of lubricant, initial particle size of excipients has no impact on compact strength not only for dibasic calcium phosphate dihydrate (brittle), but also for MCC (plastic). On the other hand, TS is dependent on particle size both with or without added lubricant for starch (viscoelastic).

Authors+Show Affiliations

Pharmaceutical Sciences Research and Development, Eli Lilly & Company, Indianapolis, IN 46285, USA. almaya_ahmad@lilly.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18431664

Citation

Almaya, Ahmad, and Aktham Aburub. "Effect of Particle Size On Compaction of Materials With Different Deformation Mechanisms With and Without Lubricants." AAPS PharmSciTech, vol. 9, no. 2, 2008, pp. 414-8.
Almaya A, Aburub A. Effect of particle size on compaction of materials with different deformation mechanisms with and without lubricants. AAPS PharmSciTech. 2008;9(2):414-8.
Almaya, A., & Aburub, A. (2008). Effect of particle size on compaction of materials with different deformation mechanisms with and without lubricants. AAPS PharmSciTech, 9(2), 414-8. https://doi.org/10.1208/s12249-008-9059-3
Almaya A, Aburub A. Effect of Particle Size On Compaction of Materials With Different Deformation Mechanisms With and Without Lubricants. AAPS PharmSciTech. 2008;9(2):414-8. PubMed PMID: 18431664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of particle size on compaction of materials with different deformation mechanisms with and without lubricants. AU - Almaya,Ahmad, AU - Aburub,Aktham, Y1 - 2008/02/28/ PY - 2007/11/02/received PY - 2008/02/04/accepted PY - 2008/4/24/pubmed PY - 2008/9/16/medline PY - 2008/4/24/entrez SP - 414 EP - 8 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 9 IS - 2 N2 - This work investigates the effect of excipient particle size on compaction properties of brittle, plastic and viscoelastic materials with and without added lubricants. Sieve cuts of microcrystalline cellulose (MCC), starch and dibasic calcium phosphate dihydrate were obtained by sieving, then samples were tested without lubrication or with added lubricant (0.5% Mg stearate mixed for either 5 or 30-min). Compacts were left overnight before testing. It was found that in the absence of lubricant, compact tensile strength (TS) was dependent on particle size only for starch. With Mg stearate, lubricant sensitivity shows a strong dependence on excipient particle size for both starch and MCC, where smaller particles are less affected by lubricant. Dibasic calcium phosphate dihydrate was not sensitive to lubricant even after 30 min mixing. This study highlights that in the absence of lubricant, initial particle size of excipients has no impact on compact strength not only for dibasic calcium phosphate dihydrate (brittle), but also for MCC (plastic). On the other hand, TS is dependent on particle size both with or without added lubricant for starch (viscoelastic). SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/18431664/Effect_of_particle_size_on_compaction_of_materials_with_different_deformation_mechanisms_with_and_without_lubricants_ DB - PRIME DP - Unbound Medicine ER -