Tags

Type your tag names separated by a space and hit enter

Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity.
AAPS PharmSciTech. 2008; 9(2):349-56.AP

Abstract

The present investigation was undertaken with the objective of formulating TC containing fast dissolving films for local delivery to oral cavity. Various film forming agents, film modifiers and polyhydric alcohols were evaluated for optimizing the composition of fast dissolving films. The potential of poloxamer 407 and hydroxypropyl-beta- cyclodextrin (HPBCD) to improve solubility of TC was investigated. Fast dissolving films containing hydroxypropyl methylcellulose (HPMC), xanthan gum, and xylitol were formulated. Use of poloxamer 407 and HPBCD resulted in significant improvement in the solubility of TC. Fast dissolving films containing TC-HPBCD complex and TC-Poloxamer 407 were formulated and were evaluated for the in vitro dissolution profile and in vitro microbiological assay. Films containing TC-Poloxamer 407 exhibited better in vitro dissolution profile and in vitro antimicrobial activity as compared to the films containing TC-HPBCD complex. Effect of incorporation of eugenol on the in vivo performance of TC-Poloxamer 407 containing films was evaluated in human volunteers. Eugenol containing films improved the acceptability of TC-Poloxamer 407 films with respect to taste masking and mouth freshening without compromising the in vivo dissolution time.

Authors+Show Affiliations

Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (E.), Mumbai 400098, India.No affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18431674

Citation

Dinge, Aditya, and Mangal Nagarsenker. "Formulation and Evaluation of Fast Dissolving Films for Delivery of Triclosan to the Oral Cavity." AAPS PharmSciTech, vol. 9, no. 2, 2008, pp. 349-56.
Dinge A, Nagarsenker M. Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity. AAPS PharmSciTech. 2008;9(2):349-56.
Dinge, A., & Nagarsenker, M. (2008). Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity. AAPS PharmSciTech, 9(2), 349-56. https://doi.org/10.1208/s12249-008-9047-7
Dinge A, Nagarsenker M. Formulation and Evaluation of Fast Dissolving Films for Delivery of Triclosan to the Oral Cavity. AAPS PharmSciTech. 2008;9(2):349-56. PubMed PMID: 18431674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity. AU - Dinge,Aditya, AU - Nagarsenker,Mangal, Y1 - 2008/02/15/ PY - 2007/10/09/received PY - 2008/01/19/accepted PY - 2008/4/24/pubmed PY - 2008/9/16/medline PY - 2008/4/24/entrez SP - 349 EP - 56 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 9 IS - 2 N2 - The present investigation was undertaken with the objective of formulating TC containing fast dissolving films for local delivery to oral cavity. Various film forming agents, film modifiers and polyhydric alcohols were evaluated for optimizing the composition of fast dissolving films. The potential of poloxamer 407 and hydroxypropyl-beta- cyclodextrin (HPBCD) to improve solubility of TC was investigated. Fast dissolving films containing hydroxypropyl methylcellulose (HPMC), xanthan gum, and xylitol were formulated. Use of poloxamer 407 and HPBCD resulted in significant improvement in the solubility of TC. Fast dissolving films containing TC-HPBCD complex and TC-Poloxamer 407 were formulated and were evaluated for the in vitro dissolution profile and in vitro microbiological assay. Films containing TC-Poloxamer 407 exhibited better in vitro dissolution profile and in vitro antimicrobial activity as compared to the films containing TC-HPBCD complex. Effect of incorporation of eugenol on the in vivo performance of TC-Poloxamer 407 containing films was evaluated in human volunteers. Eugenol containing films improved the acceptability of TC-Poloxamer 407 films with respect to taste masking and mouth freshening without compromising the in vivo dissolution time. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/18431674/Formulation_and_evaluation_of_fast_dissolving_films_for_delivery_of_triclosan_to_the_oral_cavity_ L2 - https://dx.doi.org/10.1208/s12249-008-9047-7 DB - PRIME DP - Unbound Medicine ER -