Tags

Type your tag names separated by a space and hit enter

Comparative in vitro study of six carbamazepine products.
AAPS PharmSciTech. 2008; 9(2):357-65.AP

Abstract

The purpose of present study was to evaluate commercial preparations of carbamazepine tablets with respect to drug release through a defined sequence of experiments using Minitab software. The compliance of products with respect to United States Pharmacopeia (USP) dissolution test and comparison of the products with respect to drug release in different dissolution conditions is reported in the present paper. The different dissolution conditions studied include dissolution medium (1% SLS in purified water, 0.1 N HCl), volume (900 and 1,000 ml), rpm (50 rpm, 75 rpm). Studies indicated that all six products complied with USP dissolution criteria. However, the extent of influence of dissolution conditions on drug release was varied among the products. Distinct dissolution profiles were observed and there was no correlation with disintegration time in certain products. The in vitro dissolution experimentation helped in identifying the discriminatory dissolution conditions and also the formulations that were unaffected with change of dissolution variables. In summary, commercial preparations of carbamazepine vary widely in their dissolution behavior in multi dissolution run experimentation. Identifying this behavior of the products was essential as an in vitro tool for screening a good and a bad formulation.

Links

PMC Free PDF

Authors+Show Affiliations

Mittapalli PK
University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, Andhra Pradesh, India.
Suresh B
No affiliation info available
Hussaini SS
No affiliation info available
Rao YM
No affiliation info available
Apte S
No affiliation info available

MeSH

AnticonvulsantsCarbamazepineChemistry, PharmaceuticalComputer GraphicsHydrochloric AcidKineticsQuality ControlSodium Dodecyl SulfateSoftwareSolubilityTabletsTechnology, Pharmaceutical

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18431676

Citation

Mittapalli, Pavan Kumar, et al. "Comparative in Vitro Study of Six Carbamazepine Products." AAPS PharmSciTech, vol. 9, no. 2, 2008, pp. 357-65.
Mittapalli PK, Suresh B, Hussaini SS, et al. Comparative in vitro study of six carbamazepine products. AAPS PharmSciTech. 2008;9(2):357-65.
Mittapalli, P. K., Suresh, B., Hussaini, S. S., Rao, Y. M., & Apte, S. (2008). Comparative in vitro study of six carbamazepine products. AAPS PharmSciTech, 9(2), 357-65. https://doi.org/10.1208/s12249-008-9035-y
Mittapalli PK, et al. Comparative in Vitro Study of Six Carbamazepine Products. AAPS PharmSciTech. 2008;9(2):357-65. PubMed PMID: 18431676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative in vitro study of six carbamazepine products. AU - Mittapalli,Pavan Kumar, AU - Suresh,Bandari, AU - Hussaini,S S Q, AU - Rao,Yamasani Madhusudan, AU - Apte,Shashank, Y1 - 2008/02/16/ PY - 2007/08/03/received PY - 2008/01/04/accepted PY - 2008/4/24/pubmed PY - 2008/9/16/medline PY - 2008/4/24/entrez SP - 357 EP - 65 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 9 IS - 2 N2 - The purpose of present study was to evaluate commercial preparations of carbamazepine tablets with respect to drug release through a defined sequence of experiments using Minitab software. The compliance of products with respect to United States Pharmacopeia (USP) dissolution test and comparison of the products with respect to drug release in different dissolution conditions is reported in the present paper. The different dissolution conditions studied include dissolution medium (1% SLS in purified water, 0.1 N HCl), volume (900 and 1,000 ml), rpm (50 rpm, 75 rpm). Studies indicated that all six products complied with USP dissolution criteria. However, the extent of influence of dissolution conditions on drug release was varied among the products. Distinct dissolution profiles were observed and there was no correlation with disintegration time in certain products. The in vitro dissolution experimentation helped in identifying the discriminatory dissolution conditions and also the formulations that were unaffected with change of dissolution variables. In summary, commercial preparations of carbamazepine vary widely in their dissolution behavior in multi dissolution run experimentation. Identifying this behavior of the products was essential as an in vitro tool for screening a good and a bad formulation. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/18431676/Comparative_in_vitro_study_of_six_carbamazepine_products_ DB - PRIME DP - Unbound Medicine ER -