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[Eosinophilic esophagitis: new standards in diagnosis and therapy of chronic retrosternal pain].
Dtsch Med Wochenschr 2008; 133(18):966-71DM

Abstract

Eosinophilic esophagitis is a chronic allergic inflammatory condition of the esophagus, which most often results in dysphagia, bolus impaction, heartburn or chest pain. Of particular importance is the differentiation from other inflammatory diseases of the esophagus, especially gastro-esophageal reflux disease. Response to treatment with proton pump inhibitors may help to distinguish between the different entities. The most important element in the diagnosis of eosinophilic esophagitis is to know its macro- and micromorphological characteristics. Biopsies from the proximal to the distal esophagus demonstrating > 15-20 eosinophilic granulocytes per high powered field favor the diagnosis. A multimodal therapeutic concept consists of the avoidance of specific allergens, topical or systemic glucocorticoids, oral antihistamines, leukotriene antagonists and, in cases of co-existing gastro-esophageal reflux disease, oral intake of proton pump inhibitors.

Authors+Show Affiliations

Medizinische Klinik 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Ulmenweg 18, 91054 Erlangen. Matthias.Engel@uk-erlangen.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

18431707

Citation

Engel, M A., et al. "[Eosinophilic Esophagitis: New Standards in Diagnosis and Therapy of Chronic Retrosternal Pain]." Deutsche Medizinische Wochenschrift (1946), vol. 133, no. 18, 2008, pp. 966-71.
Engel MA, Raithel M, Hahn EG, et al. [Eosinophilic esophagitis: new standards in diagnosis and therapy of chronic retrosternal pain]. Dtsch Med Wochenschr. 2008;133(18):966-71.
Engel, M. A., Raithel, M., Hahn, E. G., & Konturek, P. C. (2008). [Eosinophilic esophagitis: new standards in diagnosis and therapy of chronic retrosternal pain]. Deutsche Medizinische Wochenschrift (1946), 133(18), pp. 966-71. doi:10.1055/s-2008-1075676.
Engel MA, et al. [Eosinophilic Esophagitis: New Standards in Diagnosis and Therapy of Chronic Retrosternal Pain]. Dtsch Med Wochenschr. 2008;133(18):966-71. PubMed PMID: 18431707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Eosinophilic esophagitis: new standards in diagnosis and therapy of chronic retrosternal pain]. AU - Engel,M A, AU - Raithel,M, AU - Hahn,E G, AU - Konturek,P C, PY - 2008/4/24/pubmed PY - 2008/4/30/medline PY - 2008/4/24/entrez SP - 966 EP - 71 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch. Med. Wochenschr. VL - 133 IS - 18 N2 - Eosinophilic esophagitis is a chronic allergic inflammatory condition of the esophagus, which most often results in dysphagia, bolus impaction, heartburn or chest pain. Of particular importance is the differentiation from other inflammatory diseases of the esophagus, especially gastro-esophageal reflux disease. Response to treatment with proton pump inhibitors may help to distinguish between the different entities. The most important element in the diagnosis of eosinophilic esophagitis is to know its macro- and micromorphological characteristics. Biopsies from the proximal to the distal esophagus demonstrating > 15-20 eosinophilic granulocytes per high powered field favor the diagnosis. A multimodal therapeutic concept consists of the avoidance of specific allergens, topical or systemic glucocorticoids, oral antihistamines, leukotriene antagonists and, in cases of co-existing gastro-esophageal reflux disease, oral intake of proton pump inhibitors. SN - 1439-4413 UR - https://www.unboundmedicine.com/medline/citation/18431707/[Eosinophilic_esophagitis:_new_standards_in_diagnosis_and_therapy_of_chronic_retrosternal_pain]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2008-1075676 DB - PRIME DP - Unbound Medicine ER -