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Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process.
J Biomed Mater Res A 2009; 89(1):108-16JB

Abstract

Novel three-dimensional scaffolds consisting of nano- and microsized hydroxyapatite (HA)/poly(epsilon-caprolactone) (PCL) composite were fabricated using a modified rapid-prototyping (RP) technique for bone tissue engineering applications. The size of the nano-HA ranged from 20 to 90 nm, whereas that of the micro-HA ranged from 20 to 80 microm. The scaffold macropores were well interconnected, with a porosity of 72-73% and a pore size of 500 microm. The compressive modulus of the nano-HA/PCL and micro-HA/PCL scaffolds was 3.187 +/- 0.06 and 1.345 +/- 0.05 MPa, respectively. The higher modulus of the nano-HA/PCL composite (n-HPC) was to be likely caused by a dispersion strengthening effect. The attachment and proliferation of MG-63 cells on n-HPC were better than that on the micro-HA/PCL composite (m-HPC) scaffold. The n-HPC was more hydrophilic than the m-HPC because of the greater surface area of HA exposed to the scaffold surface. This may give rise to better cell attachment and proliferation. Bioactive n-HA/PCL composite scaffold prepared using a modified RP technique has a potential application in bone tissue engineering.

Authors+Show Affiliations

Team of BK21, First Project Team, Department of Biomedical Engineering, Inje University, Gimhae, Gyeongnam 621-749, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18431758

Citation

Heo, Su-Jin, et al. "Fabrication and Characterization of Novel Nano- and micro-HA/PCL Composite Scaffolds Using a Modified Rapid Prototyping Process." Journal of Biomedical Materials Research. Part A, vol. 89, no. 1, 2009, pp. 108-16.
Heo SJ, Kim SE, Wei J, et al. Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process. J Biomed Mater Res A. 2009;89(1):108-16.
Heo, S. J., Kim, S. E., Wei, J., Hyun, Y. T., Yun, H. S., Kim, D. H., ... Shin, J. W. (2009). Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process. Journal of Biomedical Materials Research. Part A, 89(1), pp. 108-16. doi:10.1002/jbm.a.31726.
Heo SJ, et al. Fabrication and Characterization of Novel Nano- and micro-HA/PCL Composite Scaffolds Using a Modified Rapid Prototyping Process. J Biomed Mater Res A. 2009;89(1):108-16. PubMed PMID: 18431758.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process. AU - Heo,Su-Jin, AU - Kim,Seung-Eon, AU - Wei,Jie, AU - Hyun,Yong-Taek, AU - Yun,Hui-Suk, AU - Kim,Dong-Hwa, AU - Shin,Ji Won, AU - Shin,Jung-Woog, PY - 2008/4/24/pubmed PY - 2009/5/12/medline PY - 2008/4/24/entrez SP - 108 EP - 16 JF - Journal of biomedical materials research. Part A JO - J Biomed Mater Res A VL - 89 IS - 1 N2 - Novel three-dimensional scaffolds consisting of nano- and microsized hydroxyapatite (HA)/poly(epsilon-caprolactone) (PCL) composite were fabricated using a modified rapid-prototyping (RP) technique for bone tissue engineering applications. The size of the nano-HA ranged from 20 to 90 nm, whereas that of the micro-HA ranged from 20 to 80 microm. The scaffold macropores were well interconnected, with a porosity of 72-73% and a pore size of 500 microm. The compressive modulus of the nano-HA/PCL and micro-HA/PCL scaffolds was 3.187 +/- 0.06 and 1.345 +/- 0.05 MPa, respectively. The higher modulus of the nano-HA/PCL composite (n-HPC) was to be likely caused by a dispersion strengthening effect. The attachment and proliferation of MG-63 cells on n-HPC were better than that on the micro-HA/PCL composite (m-HPC) scaffold. The n-HPC was more hydrophilic than the m-HPC because of the greater surface area of HA exposed to the scaffold surface. This may give rise to better cell attachment and proliferation. Bioactive n-HA/PCL composite scaffold prepared using a modified RP technique has a potential application in bone tissue engineering. SN - 1552-4965 UR - https://www.unboundmedicine.com/medline/citation/18431758/Fabrication_and_characterization_of_novel_nano__and_micro_HA/PCL_composite_scaffolds_using_a_modified_rapid_prototyping_process_ L2 - https://doi.org/10.1002/jbm.a.31726 DB - PRIME DP - Unbound Medicine ER -