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Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice.
J Ethnopharmacol. 2008 Jun 19; 118(1):7-13.JE

Abstract

AIM OF THE STUDY

The antihyperglycemic and antilipidperoxidative effects of the dry matter of culture broth (DMCB) of Inonotus obliquus were investigated.

MATERIALS AND METHODS

The normal, glucose-induced hyperglycemic and alloxan-induced diabetic mice were used to evaluate the antihyperglycemic and antilipidperoxidative effects of the DMCB of Inonotus obliquus.

RESULTS

Treatment with the DMCB (500 and 1000 mg/kg body weight) exhibited a mild hypoglycemic effect in normal mice, and failed to reduce the peak glucose levels after glucose administration. However, euglycemia was achieved in the DMCB of Inonotus obliquus (1000 mg/kg) and glibenclamide-treated mice after 120 min of glucose loading. In alloxan-induced diabetic mice, the DMCB (500 and 1000 mg/kg body weight for 21 days) showed a significant decrease in blood glucose level, the percentages reduction on the 7th day were 11.90 and 15.79%, respectively. However, feeding of this drug for 3 weeks produced reduction was 30.07 and 31.30%. Furthermore, the DMCB treatment significantly decreased serum contents of free fatty acid (FFA), total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C), whereas effectively increased high density lipoprotein-cholesterol (HDL-C), insulin level and hepatic glycogen contents in liver on diabetic mice. Besides, the DMCB treatment significantly increased catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities except for decreasing maleic dialdehyde (MDA) level in diabetic mice. Histological morphology examination showed that the DMCB restored the damage of pancreas tissues in mice with diabetes mellitus.

CONCLUSIONS

The results showed that the DMCB of Inonotus obliquus possesses significant antihyperglycemic, antilipidperoxidative and antioxidant effects in alloxan-induced diabetic mice.

Authors+Show Affiliations

Lab of Pharmaceutical Engineering, School of Medicine and Pharmaceutics, Jiangnan University, Wuxi, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18434051

Citation

Sun, Jun-En, et al. "Antihyperglycemic and Antilipidperoxidative Effects of Dry Matter of Culture Broth of Inonotus Obliquus in Submerged Culture On Normal and Alloxan-diabetes Mice." Journal of Ethnopharmacology, vol. 118, no. 1, 2008, pp. 7-13.
Sun JE, Ao ZH, Lu ZM, et al. Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. J Ethnopharmacol. 2008;118(1):7-13.
Sun, J. E., Ao, Z. H., Lu, Z. M., Xu, H. Y., Zhang, X. M., Dou, W. F., & Xu, Z. H. (2008). Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. Journal of Ethnopharmacology, 118(1), 7-13. https://doi.org/10.1016/j.jep.2008.02.030
Sun JE, et al. Antihyperglycemic and Antilipidperoxidative Effects of Dry Matter of Culture Broth of Inonotus Obliquus in Submerged Culture On Normal and Alloxan-diabetes Mice. J Ethnopharmacol. 2008 Jun 19;118(1):7-13. PubMed PMID: 18434051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice. AU - Sun,Jun-En, AU - Ao,Zong-Hua, AU - Lu,Zhen-Ming, AU - Xu,Hong-Yu, AU - Zhang,Xiao-Mei, AU - Dou,Wen-Fang, AU - Xu,Zheng-Hong, Y1 - 2008/03/04/ PY - 2007/09/06/received PY - 2008/01/23/revised PY - 2008/02/14/accepted PY - 2008/4/25/pubmed PY - 2008/11/11/medline PY - 2008/4/25/entrez SP - 7 EP - 13 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 118 IS - 1 N2 - AIM OF THE STUDY: The antihyperglycemic and antilipidperoxidative effects of the dry matter of culture broth (DMCB) of Inonotus obliquus were investigated. MATERIALS AND METHODS: The normal, glucose-induced hyperglycemic and alloxan-induced diabetic mice were used to evaluate the antihyperglycemic and antilipidperoxidative effects of the DMCB of Inonotus obliquus. RESULTS: Treatment with the DMCB (500 and 1000 mg/kg body weight) exhibited a mild hypoglycemic effect in normal mice, and failed to reduce the peak glucose levels after glucose administration. However, euglycemia was achieved in the DMCB of Inonotus obliquus (1000 mg/kg) and glibenclamide-treated mice after 120 min of glucose loading. In alloxan-induced diabetic mice, the DMCB (500 and 1000 mg/kg body weight for 21 days) showed a significant decrease in blood glucose level, the percentages reduction on the 7th day were 11.90 and 15.79%, respectively. However, feeding of this drug for 3 weeks produced reduction was 30.07 and 31.30%. Furthermore, the DMCB treatment significantly decreased serum contents of free fatty acid (FFA), total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C), whereas effectively increased high density lipoprotein-cholesterol (HDL-C), insulin level and hepatic glycogen contents in liver on diabetic mice. Besides, the DMCB treatment significantly increased catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities except for decreasing maleic dialdehyde (MDA) level in diabetic mice. Histological morphology examination showed that the DMCB restored the damage of pancreas tissues in mice with diabetes mellitus. CONCLUSIONS: The results showed that the DMCB of Inonotus obliquus possesses significant antihyperglycemic, antilipidperoxidative and antioxidant effects in alloxan-induced diabetic mice. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18434051/Antihyperglycemic_and_antilipidperoxidative_effects_of_dry_matter_of_culture_broth_of_Inonotus_obliquus_in_submerged_culture_on_normal_and_alloxan_diabetes_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00108-6 DB - PRIME DP - Unbound Medicine ER -