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Measurement of the kidney function in patients with rheumatoid arthritis: plasma cystatin C versus 51Cr-EDTA clearance.
Nephron Clin Pract. 2008; 108(4):c284-90.NC

Abstract

BACKGROUND/AIM

Knowledge of the usefulness of cystatin C measurement in the detection of chronic kidney disease in patients with rheumatoid arthritis (RA) is scant. The purpose of this study was to evaluate the ability of plasma cystatin C- and creatinine-based methods to predict glomerular filtration rate (GFR) and classify chronic kidney disease in RA patients.

METHODS

The study population consisted of 64 RA patients aged 41-86 years. Comparisons were made between measured plasma creatinine, cystatin C, creatinine clearance and GFR estimated by the Cockcroft-Gault (CG) and the Modification of Diet in Renal Disease (MDRD) formulas. The plasma clearance of (51)Cr-EDTA served as a reference.

RESULTS

The Pearson correlation coefficients between plasma clearance of (51)Cr-EDTA and the markers of GFR were calculated. The correlation coefficients were 0.800 for plasma creatinine, 0.863 for cystatin C, 0.866 and 0.904 for GFR values estimated by MDRD and CG and 0.922 for plasma creatinine clearance. Statistically significant differences were detected between the correlation coefficients of plasma creatinine and GFR estimated by CG (p = 0.0412) and plasma creatinine and creatinine clearance (p = 0.0099). Creatinine clearance and the MDRD and CG formulas proved to be better at identifying GFR <90 ml/min than plasma creatinine or cystatin C.

CONCLUSION

We recommend using the CG formula or creatinine clearance for the estimation of the GFR of RA patients instead of solely creatinine or cystatin C in clinical work.

Authors+Show Affiliations

Department of Internal Medicine, Tampere University Hospital, Tampere, Finland. krista.karstila@fimnet.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18434750

Citation

Karstila, Krista, et al. "Measurement of the Kidney Function in Patients With Rheumatoid Arthritis: Plasma Cystatin C Versus 51Cr-EDTA Clearance." Nephron. Clinical Practice, vol. 108, no. 4, 2008, pp. c284-90.
Karstila K, Harmoinen AP, Lehtimäki TJ, et al. Measurement of the kidney function in patients with rheumatoid arthritis: plasma cystatin C versus 51Cr-EDTA clearance. Nephron Clin Pract. 2008;108(4):c284-90.
Karstila, K., Harmoinen, A. P., Lehtimäki, T. J., Korpela, M. M., Mustonen, J. T., & Saha, H. H. (2008). Measurement of the kidney function in patients with rheumatoid arthritis: plasma cystatin C versus 51Cr-EDTA clearance. Nephron. Clinical Practice, 108(4), c284-90. https://doi.org/10.1159/000127362
Karstila K, et al. Measurement of the Kidney Function in Patients With Rheumatoid Arthritis: Plasma Cystatin C Versus 51Cr-EDTA Clearance. Nephron Clin Pract. 2008;108(4):c284-90. PubMed PMID: 18434750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measurement of the kidney function in patients with rheumatoid arthritis: plasma cystatin C versus 51Cr-EDTA clearance. AU - Karstila,Krista, AU - Harmoinen,Aimo P T, AU - Lehtimäki,Terho J, AU - Korpela,Markku M, AU - Mustonen,Jukka T, AU - Saha,Heikki H T, Y1 - 2008/04/22/ PY - 2007/10/10/received PY - 2008/01/13/accepted PY - 2008/4/25/pubmed PY - 2008/7/3/medline PY - 2008/4/25/entrez SP - c284 EP - 90 JF - Nephron. Clinical practice JO - Nephron Clin Pract VL - 108 IS - 4 N2 - BACKGROUND/AIM: Knowledge of the usefulness of cystatin C measurement in the detection of chronic kidney disease in patients with rheumatoid arthritis (RA) is scant. The purpose of this study was to evaluate the ability of plasma cystatin C- and creatinine-based methods to predict glomerular filtration rate (GFR) and classify chronic kidney disease in RA patients. METHODS: The study population consisted of 64 RA patients aged 41-86 years. Comparisons were made between measured plasma creatinine, cystatin C, creatinine clearance and GFR estimated by the Cockcroft-Gault (CG) and the Modification of Diet in Renal Disease (MDRD) formulas. The plasma clearance of (51)Cr-EDTA served as a reference. RESULTS: The Pearson correlation coefficients between plasma clearance of (51)Cr-EDTA and the markers of GFR were calculated. The correlation coefficients were 0.800 for plasma creatinine, 0.863 for cystatin C, 0.866 and 0.904 for GFR values estimated by MDRD and CG and 0.922 for plasma creatinine clearance. Statistically significant differences were detected between the correlation coefficients of plasma creatinine and GFR estimated by CG (p = 0.0412) and plasma creatinine and creatinine clearance (p = 0.0099). Creatinine clearance and the MDRD and CG formulas proved to be better at identifying GFR <90 ml/min than plasma creatinine or cystatin C. CONCLUSION: We recommend using the CG formula or creatinine clearance for the estimation of the GFR of RA patients instead of solely creatinine or cystatin C in clinical work. SN - 1660-2110 UR - https://www.unboundmedicine.com/medline/citation/18434750/Measurement_of_the_kidney_function_in_patients_with_rheumatoid_arthritis:_plasma_cystatin_C_versus_51Cr_EDTA_clearance_ L2 - https://www.karger.com?DOI=10.1159/000127362 DB - PRIME DP - Unbound Medicine ER -