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Atovaquone-proguanil resistance in imported falciparum malaria in a young child.
Pediatr Infect Dis J. 2008 Jun; 27(6):567-9.PI

Abstract

We discuss a case of atovaquone-proguanil treatment failure in a child from Mozambique, recently arrived in North America. Four weeks after completing therapy, symptomatic parasitemia recurred, caused by Plasmodium falciparum parasites bearing a Tyr268Ser mutation in cytochrome b. We review the literature concerning atovaquone-proguanil resistance, and emphasize the importance of follow-up and consideration of resistance where patients have relapsed symptoms.

Authors+Show Affiliations

Division of Infectious Diseases, The Ottawa Hospital, Ottawa, ON, Canada. grrose@ottawahospital.on.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18434932

Citation

Rose, Gregory W., et al. "Atovaquone-proguanil Resistance in Imported Falciparum Malaria in a Young Child." The Pediatric Infectious Disease Journal, vol. 27, no. 6, 2008, pp. 567-9.
Rose GW, Suh KN, Kain KC, et al. Atovaquone-proguanil resistance in imported falciparum malaria in a young child. Pediatr Infect Dis J. 2008;27(6):567-9.
Rose, G. W., Suh, K. N., Kain, K. C., Le Saux, N., & McCarthy, A. E. (2008). Atovaquone-proguanil resistance in imported falciparum malaria in a young child. The Pediatric Infectious Disease Journal, 27(6), 567-9. https://doi.org/10.1097/INF.0b013e318167918d
Rose GW, et al. Atovaquone-proguanil Resistance in Imported Falciparum Malaria in a Young Child. Pediatr Infect Dis J. 2008;27(6):567-9. PubMed PMID: 18434932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atovaquone-proguanil resistance in imported falciparum malaria in a young child. AU - Rose,Gregory W, AU - Suh,Kathryn N, AU - Kain,Kevin C, AU - Le Saux,Nicole, AU - McCarthy,Anne E, PY - 2008/4/25/pubmed PY - 2008/7/4/medline PY - 2008/4/25/entrez SP - 567 EP - 9 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 27 IS - 6 N2 - We discuss a case of atovaquone-proguanil treatment failure in a child from Mozambique, recently arrived in North America. Four weeks after completing therapy, symptomatic parasitemia recurred, caused by Plasmodium falciparum parasites bearing a Tyr268Ser mutation in cytochrome b. We review the literature concerning atovaquone-proguanil resistance, and emphasize the importance of follow-up and consideration of resistance where patients have relapsed symptoms. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/18434932/Atovaquone_proguanil_resistance_in_imported_falciparum_malaria_in_a_young_child_ L2 - https://doi.org/10.1097/INF.0b013e318167918d DB - PRIME DP - Unbound Medicine ER -