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Chromatographic fingerprint analysis and characterization of furocoumarins in the roots of Angelica dahurica by HPLC/DAD/ESI-MSn technique.
J Pharm Biomed Anal. 2008 Aug 05; 47(4-5):778-85.JP

Abstract

A high performance liquid chromatography-diode array detection-electrospray ionization tandem mass spectrometry (HPLC/DAD/ESI-MSn) method was used for the chromatographic fingerprint analysis and characterization of furocoumarins in the roots of Angelica dahurica for the first time. Nine "common peaks" were identified by comparing with the retention time, UV and MS spectra of reference furocoumarins. The software "Similarity Evaluation System for Chromatographic Fingerprint of TCM" was used to evaluate the similarities of 13 batches of Baizhi samples collected from Henan, Zhejiang, Sichuan and Anhui provinces of China. The results indicated that the samples from different batches had similar HPLC fingerprints, and the method could be applied for the quality control of the roots of Angelica dahurica. In addition, a total of 20 furocoumarins were identified or tentatively characterized by HPLC/DAD/ESI-MSn technique, and their fragmentation patterns in an electrospray ion trap mass spectrometer were also summarized.

Authors+Show Affiliations

The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Beijing 100083, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18436412

Citation

Kang, Jie, et al. "Chromatographic Fingerprint Analysis and Characterization of Furocoumarins in the Roots of Angelica Dahurica By HPLC/DAD/ESI-MSn Technique." Journal of Pharmaceutical and Biomedical Analysis, vol. 47, no. 4-5, 2008, pp. 778-85.
Kang J, Zhou L, Sun J, et al. Chromatographic fingerprint analysis and characterization of furocoumarins in the roots of Angelica dahurica by HPLC/DAD/ESI-MSn technique. J Pharm Biomed Anal. 2008;47(4-5):778-85.
Kang, J., Zhou, L., Sun, J., Han, J., & Guo, D. A. (2008). Chromatographic fingerprint analysis and characterization of furocoumarins in the roots of Angelica dahurica by HPLC/DAD/ESI-MSn technique. Journal of Pharmaceutical and Biomedical Analysis, 47(4-5), 778-85. https://doi.org/10.1016/j.jpba.2008.03.010
Kang J, et al. Chromatographic Fingerprint Analysis and Characterization of Furocoumarins in the Roots of Angelica Dahurica By HPLC/DAD/ESI-MSn Technique. J Pharm Biomed Anal. 2008 Aug 5;47(4-5):778-85. PubMed PMID: 18436412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chromatographic fingerprint analysis and characterization of furocoumarins in the roots of Angelica dahurica by HPLC/DAD/ESI-MSn technique. AU - Kang,Jie, AU - Zhou,Lei, AU - Sun,Jianghao, AU - Han,Jian, AU - Guo,De-An, Y1 - 2008/03/16/ PY - 2007/08/21/received PY - 2008/03/08/revised PY - 2008/03/10/accepted PY - 2008/4/26/pubmed PY - 2008/9/4/medline PY - 2008/4/26/entrez SP - 778 EP - 85 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 47 IS - 4-5 N2 - A high performance liquid chromatography-diode array detection-electrospray ionization tandem mass spectrometry (HPLC/DAD/ESI-MSn) method was used for the chromatographic fingerprint analysis and characterization of furocoumarins in the roots of Angelica dahurica for the first time. Nine "common peaks" were identified by comparing with the retention time, UV and MS spectra of reference furocoumarins. The software "Similarity Evaluation System for Chromatographic Fingerprint of TCM" was used to evaluate the similarities of 13 batches of Baizhi samples collected from Henan, Zhejiang, Sichuan and Anhui provinces of China. The results indicated that the samples from different batches had similar HPLC fingerprints, and the method could be applied for the quality control of the roots of Angelica dahurica. In addition, a total of 20 furocoumarins were identified or tentatively characterized by HPLC/DAD/ESI-MSn technique, and their fragmentation patterns in an electrospray ion trap mass spectrometer were also summarized. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/18436412/Chromatographic_fingerprint_analysis_and_characterization_of_furocoumarins_in_the_roots_of_Angelica_dahurica_by_HPLC/DAD/ESI_MSn_technique_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(08)00164-7 DB - PRIME DP - Unbound Medicine ER -