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The effect of n-3 fatty acids on lipids and lipoproteins in patients treated with chronic haemodialysis: a randomized placebo-controlled intervention study.
Nephrol Dial Transplant. 2008 Sep; 23(9):2918-24.ND

Abstract

BACKGROUND

Patients with end-stage renal disease (ESRD) have an increased mortality, mainly due to cardiovascular disease (CVD). ESRD is accompanied by several lipid abnormalities, which may be responsible for part of the increased risk of CVD in this population. n-3 polyunsaturated fatty acids (PUFA) lower plasma triglycerides in patients with normal renal function. The aim of the present study was to examine the effect of n-3 PUFA on serum lipid and lipoproteins in patients treated with chronic haemodialysis (HD).

METHODS

In a double-blind randomized placebo-controlled design, patients with documented CVD, treated with HD for a minimum of 6 months, were randomized to treatment with n-3 PUFA or a control treatment (olive oil). A dietary intake of n-3 PUFA was assessed with a dietary questionnaire. Plasma lipids and lipoproteins and the content of n-3 PUFA in serum phospholipids were measured at baseline and after 3 months.

RESULTS

Two hundred and six patients were included. Serum phospholipid levels of n-3 PUFA were significantly higher in patients reporting a high fish intake compared to patients reporting a low fish intake. After 3 months, a significant decrease was seen in serum triglycerides in the n-3 PUFA group compared to the control group (P = 0.01). No significant effect was seen on total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, Lp(a) or apoB.

CONCLUSION

In patients treated with HD, consumption of fish increases levels of n-3 PUFA. Additional supplementation with n-3 PUFA for 3 months further increases levels of n-3 PUFA and lowers serum triglycerides, but does not significantly affect other plasma lipids or lipoproteins.

Authors+Show Affiliations

Department of Nephrology, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-20, Aalborg 9100, Denmark. my_svensson@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18436564

Citation

Svensson, My, et al. "The Effect of N-3 Fatty Acids On Lipids and Lipoproteins in Patients Treated With Chronic Haemodialysis: a Randomized Placebo-controlled Intervention Study." Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, vol. 23, no. 9, 2008, pp. 2918-24.
Svensson M, Schmidt EB, Jørgensen KA, et al. The effect of n-3 fatty acids on lipids and lipoproteins in patients treated with chronic haemodialysis: a randomized placebo-controlled intervention study. Nephrol Dial Transplant. 2008;23(9):2918-24.
Svensson, M., Schmidt, E. B., Jørgensen, K. A., & Christensen, J. H. (2008). The effect of n-3 fatty acids on lipids and lipoproteins in patients treated with chronic haemodialysis: a randomized placebo-controlled intervention study. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association, 23(9), 2918-24. https://doi.org/10.1093/ndt/gfn180
Svensson M, et al. The Effect of N-3 Fatty Acids On Lipids and Lipoproteins in Patients Treated With Chronic Haemodialysis: a Randomized Placebo-controlled Intervention Study. Nephrol Dial Transplant. 2008;23(9):2918-24. PubMed PMID: 18436564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of n-3 fatty acids on lipids and lipoproteins in patients treated with chronic haemodialysis: a randomized placebo-controlled intervention study. AU - Svensson,My, AU - Schmidt,Erik B, AU - Jørgensen,Kaj A, AU - Christensen,Jeppe H, Y1 - 2008/04/24/ PY - 2008/4/26/pubmed PY - 2009/2/12/medline PY - 2008/4/26/entrez SP - 2918 EP - 24 JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association JO - Nephrol. Dial. Transplant. VL - 23 IS - 9 N2 - BACKGROUND: Patients with end-stage renal disease (ESRD) have an increased mortality, mainly due to cardiovascular disease (CVD). ESRD is accompanied by several lipid abnormalities, which may be responsible for part of the increased risk of CVD in this population. n-3 polyunsaturated fatty acids (PUFA) lower plasma triglycerides in patients with normal renal function. The aim of the present study was to examine the effect of n-3 PUFA on serum lipid and lipoproteins in patients treated with chronic haemodialysis (HD). METHODS: In a double-blind randomized placebo-controlled design, patients with documented CVD, treated with HD for a minimum of 6 months, were randomized to treatment with n-3 PUFA or a control treatment (olive oil). A dietary intake of n-3 PUFA was assessed with a dietary questionnaire. Plasma lipids and lipoproteins and the content of n-3 PUFA in serum phospholipids were measured at baseline and after 3 months. RESULTS: Two hundred and six patients were included. Serum phospholipid levels of n-3 PUFA were significantly higher in patients reporting a high fish intake compared to patients reporting a low fish intake. After 3 months, a significant decrease was seen in serum triglycerides in the n-3 PUFA group compared to the control group (P = 0.01). No significant effect was seen on total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, Lp(a) or apoB. CONCLUSION: In patients treated with HD, consumption of fish increases levels of n-3 PUFA. Additional supplementation with n-3 PUFA for 3 months further increases levels of n-3 PUFA and lowers serum triglycerides, but does not significantly affect other plasma lipids or lipoproteins. SN - 1460-2385 UR - https://www.unboundmedicine.com/medline/citation/18436564/The_effect_of_n_3_fatty_acids_on_lipids_and_lipoproteins_in_patients_treated_with_chronic_haemodialysis:_a_randomized_placebo_controlled_intervention_study_ L2 - https://academic.oup.com/ndt/article-lookup/doi/10.1093/ndt/gfn180 DB - PRIME DP - Unbound Medicine ER -