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Retinal vascular caliber, blood pressure, and cardiovascular risk factors in an Asian population: the Singapore Malay Eye Study.
Invest Ophthalmol Vis Sci. 2008 May; 49(5):1784-90.IO

Abstract

PURPOSE

To describe the relationship of retinal vascular caliber with cardiovascular risk factors in an Asian population.

METHODS

The Singapore Malay Eye Study is a population-based, cross-sectional survey that included 3280 (78.7% response) persons aged 40 to 80 years. Retinal vascular caliber was measured from digital retinal photographs using a validated standardized protocol. Data on major cardiovascular risk factors were collected from all participants.

RESULTS

Of the 3019 participants with retinal vascular caliber data available, the mean retinal arteriolar caliber (CRAE) was 139.5 +/- 15.7 microm (SD), and mean venular caliber (CRVE) was 219.3 +/- 22.2 microm (SD). Smaller retinal arteriolar caliber was associated with higher current mean blood pressure and male sex (P < 0.001 for both). Larger retinal venular caliber was associated with younger age, current cigarette smoking, greater body mass index, higher glycosylated hemoglobin level, and lower HDL cholesterol (P = 0.012 for glycosylated hemoglobin level and P < 0.001 for other risk factors). The association of retinal arteriolar narrowing and blood pressure was stronger in younger people than in older people and in men than in women (P for interaction < 0.001 for both).

CONCLUSIONS

In this Asian population, smaller retinal arteriolar caliber was associated with hypertension and larger retinal venular caliber with cigarette smoking, dyslipidemia, hyperglycemia, and higher body mass index. The pattern of these associations is similar to that in white populations.

Authors+Show Affiliations

Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, Melbourne, Victoria 3002, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18436813

Citation

Sun, Cong, et al. "Retinal Vascular Caliber, Blood Pressure, and Cardiovascular Risk Factors in an Asian Population: the Singapore Malay Eye Study." Investigative Ophthalmology & Visual Science, vol. 49, no. 5, 2008, pp. 1784-90.
Sun C, Liew G, Wang JJ, et al. Retinal vascular caliber, blood pressure, and cardiovascular risk factors in an Asian population: the Singapore Malay Eye Study. Invest Ophthalmol Vis Sci. 2008;49(5):1784-90.
Sun, C., Liew, G., Wang, J. J., Mitchell, P., Saw, S. M., Aung, T., Tai, E. S., & Wong, T. Y. (2008). Retinal vascular caliber, blood pressure, and cardiovascular risk factors in an Asian population: the Singapore Malay Eye Study. Investigative Ophthalmology & Visual Science, 49(5), 1784-90. https://doi.org/10.1167/iovs.07-1450
Sun C, et al. Retinal Vascular Caliber, Blood Pressure, and Cardiovascular Risk Factors in an Asian Population: the Singapore Malay Eye Study. Invest Ophthalmol Vis Sci. 2008;49(5):1784-90. PubMed PMID: 18436813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retinal vascular caliber, blood pressure, and cardiovascular risk factors in an Asian population: the Singapore Malay Eye Study. AU - Sun,Cong, AU - Liew,Gerald, AU - Wang,Jie Jin, AU - Mitchell,Paul, AU - Saw,Seang Mei, AU - Aung,Tin, AU - Tai,E Shyong, AU - Wong,Tien Y, PY - 2008/4/26/pubmed PY - 2008/6/10/medline PY - 2008/4/26/entrez SP - 1784 EP - 90 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 49 IS - 5 N2 - PURPOSE: To describe the relationship of retinal vascular caliber with cardiovascular risk factors in an Asian population. METHODS: The Singapore Malay Eye Study is a population-based, cross-sectional survey that included 3280 (78.7% response) persons aged 40 to 80 years. Retinal vascular caliber was measured from digital retinal photographs using a validated standardized protocol. Data on major cardiovascular risk factors were collected from all participants. RESULTS: Of the 3019 participants with retinal vascular caliber data available, the mean retinal arteriolar caliber (CRAE) was 139.5 +/- 15.7 microm (SD), and mean venular caliber (CRVE) was 219.3 +/- 22.2 microm (SD). Smaller retinal arteriolar caliber was associated with higher current mean blood pressure and male sex (P < 0.001 for both). Larger retinal venular caliber was associated with younger age, current cigarette smoking, greater body mass index, higher glycosylated hemoglobin level, and lower HDL cholesterol (P = 0.012 for glycosylated hemoglobin level and P < 0.001 for other risk factors). The association of retinal arteriolar narrowing and blood pressure was stronger in younger people than in older people and in men than in women (P for interaction < 0.001 for both). CONCLUSIONS: In this Asian population, smaller retinal arteriolar caliber was associated with hypertension and larger retinal venular caliber with cigarette smoking, dyslipidemia, hyperglycemia, and higher body mass index. The pattern of these associations is similar to that in white populations. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/18436813/Retinal_vascular_caliber_blood_pressure_and_cardiovascular_risk_factors_in_an_Asian_population:_the_Singapore_Malay_Eye_Study_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.07-1450 DB - PRIME DP - Unbound Medicine ER -