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[Meningovascular syphilis: study of five cases].
Rev Neurol (Paris) 2008; 164(4):369-73RN

Abstract

INTRODUCTION

Clinical manifestations of syphilis are highly variable, and currently on the rise. We report five cases of ischemic stroke related to neurosyphilis.

CASE REPORT

The cases of five men aged 37, 34, 41, 42 and 44 years are reported. A notion of a genital chancre was noted in three. The clinical presentation was typical of ischemic stroke in four patients. One presented with intellectual deterioration. Imaging revealed zones of ischemia in all five patients. Examination of the cerebrospinal fluid revealed lymphocytic meningitis and all five patients exhibited positive syphilis serology. Brain angiography demonstrated signs of arthritis in four patients and carotid dissection in one. Improvement was achieved with penicillin G in four patients.

CONCLUSION

When the cause is doubtful, the routine work-up for ischemic stroke in young subjects should include syphilis serology.

Authors+Show Affiliations

Service de neurologie, hôpital Militaire d'instruction Mohammed-V, Rabat, Morocco. ahmed_21s@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

18439929

Citation

Bourazza, A, et al. "[Meningovascular Syphilis: Study of Five Cases]." Revue Neurologique, vol. 164, no. 4, 2008, pp. 369-73.
Bourazza A, Kerouache A, Reda R, et al. [Meningovascular syphilis: study of five cases]. Rev Neurol (Paris). 2008;164(4):369-73.
Bourazza, A., Kerouache, A., Reda, R., Mounach, J., & Mosseddaq, R. (2008). [Meningovascular syphilis: study of five cases]. Revue Neurologique, 164(4), pp. 369-73. doi:10.1016/j.neurol.2007.12.007.
Bourazza A, et al. [Meningovascular Syphilis: Study of Five Cases]. Rev Neurol (Paris). 2008;164(4):369-73. PubMed PMID: 18439929.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Meningovascular syphilis: study of five cases]. AU - Bourazza,A, AU - Kerouache,A, AU - Reda,R, AU - Mounach,J, AU - Mosseddaq,R, Y1 - 2008/04/01/ PY - 2003/12/04/received PY - 2007/12/18/revised PY - 2007/12/26/accepted PY - 2008/4/29/pubmed PY - 2008/8/9/medline PY - 2008/4/29/entrez SP - 369 EP - 73 JF - Revue neurologique JO - Rev. Neurol. (Paris) VL - 164 IS - 4 N2 - INTRODUCTION: Clinical manifestations of syphilis are highly variable, and currently on the rise. We report five cases of ischemic stroke related to neurosyphilis. CASE REPORT: The cases of five men aged 37, 34, 41, 42 and 44 years are reported. A notion of a genital chancre was noted in three. The clinical presentation was typical of ischemic stroke in four patients. One presented with intellectual deterioration. Imaging revealed zones of ischemia in all five patients. Examination of the cerebrospinal fluid revealed lymphocytic meningitis and all five patients exhibited positive syphilis serology. Brain angiography demonstrated signs of arthritis in four patients and carotid dissection in one. Improvement was achieved with penicillin G in four patients. CONCLUSION: When the cause is doubtful, the routine work-up for ischemic stroke in young subjects should include syphilis serology. SN - 0035-3787 UR - https://www.unboundmedicine.com/medline/citation/18439929/[Meningovascular_syphilis:_study_of_five_cases]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0035-3787(08)00102-1 DB - PRIME DP - Unbound Medicine ER -