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White-matter vascular lesions correlate with alpha EEG sources in mild cognitive impairment.
Neuropsychologia. 2008; 46(6):1707-20.N

Abstract

It is an open issue if vascular and Alzheimer's disease (AD) lesions represent additive factors in the development of mild cognitive impairment (MCI), as a preclinical stage of Alzheimer's disease (AD) at group level. In the present study, we tested the hypothesis that electroencephalographic (EEG) alpha rhythms, which are affected (i.e. decreased in amplitude) by AD processes, are relatively preserved in MCI subjects in whom the cognitive decline is mainly explained by white-matter vascular load. Resting EEG was recorded in 40 healthy elderly (Nold), 80 MCI, and 40 AD subjects. In the MCI subjects, white-matter vascular load was quantified based on MRI (0-30 Wahlund visual rating scale). EEG rhythms of interest were delta (2-4Hz), theta (4-8Hz), alpha 1 (8-10.5Hz), alpha 2 (10.5-13Hz), beta 1 (13-20Hz), and beta 2 (20-30Hz). Low resolution electromagnetic source tomography (LORETA) was used for EEG source analysis. As expected, we observed that alpha 1 sources in parietal, occipital, and temporal areas were lower in amplitude in the AD and MCI subjects than in the Nold subjects, whereas the amplitude of wide delta sources was higher in the AD than in the Nold and MCI subjects. As novel results, the amplitude of parietal, occipital, and temporal alpha 1 sources was higher in the MCI V+ (high vascular load; N=42; MMSE=26) than MCI V- group (low vascular load; N=37; MMSE=26.7). Furthermore, a weak but significant (p<0.05) positive statistical correlation was found between the parietal alpha 1 sources and the score of Wahlund scale across all MCI subjects (i.e. the more severe white-matter lesions, the higher parietal alpha source power). The present results are in line with the additive model of cognitive impairment postulating that this arises as the sum of neurodegenerative and cerebrovascular lesions.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Foggia, Foggia, Italy; Casa di Cura San Raffaele Cassino, IRCCS San Raffaele Pisana, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18440574

Citation

Babiloni, Claudio, et al. "White-matter Vascular Lesions Correlate With Alpha EEG Sources in Mild Cognitive Impairment." Neuropsychologia, vol. 46, no. 6, 2008, pp. 1707-20.
Babiloni C, Frisoni GB, Pievani M, et al. White-matter vascular lesions correlate with alpha EEG sources in mild cognitive impairment. Neuropsychologia. 2008;46(6):1707-20.
Babiloni, C., Frisoni, G. B., Pievani, M., Toscano, L., Del Percio, C., Geroldi, C., Eusebi, F., Miniussi, C., & Rossini, P. M. (2008). White-matter vascular lesions correlate with alpha EEG sources in mild cognitive impairment. Neuropsychologia, 46(6), 1707-20. https://doi.org/10.1016/j.neuropsychologia.2008.03.021
Babiloni C, et al. White-matter Vascular Lesions Correlate With Alpha EEG Sources in Mild Cognitive Impairment. Neuropsychologia. 2008;46(6):1707-20. PubMed PMID: 18440574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - White-matter vascular lesions correlate with alpha EEG sources in mild cognitive impairment. AU - Babiloni,Claudio, AU - Frisoni,Giovanni B, AU - Pievani,Michela, AU - Toscano,Leonia, AU - Del Percio,Claudio, AU - Geroldi,Cristina, AU - Eusebi,Fabrizio, AU - Miniussi,Carlo, AU - Rossini,Paolo M, Y1 - 2008/04/08/ PY - 2007/04/28/received PY - 2008/03/28/revised PY - 2008/03/31/accepted PY - 2008/4/29/pubmed PY - 2008/9/25/medline PY - 2008/4/29/entrez SP - 1707 EP - 20 JF - Neuropsychologia JO - Neuropsychologia VL - 46 IS - 6 N2 - It is an open issue if vascular and Alzheimer's disease (AD) lesions represent additive factors in the development of mild cognitive impairment (MCI), as a preclinical stage of Alzheimer's disease (AD) at group level. In the present study, we tested the hypothesis that electroencephalographic (EEG) alpha rhythms, which are affected (i.e. decreased in amplitude) by AD processes, are relatively preserved in MCI subjects in whom the cognitive decline is mainly explained by white-matter vascular load. Resting EEG was recorded in 40 healthy elderly (Nold), 80 MCI, and 40 AD subjects. In the MCI subjects, white-matter vascular load was quantified based on MRI (0-30 Wahlund visual rating scale). EEG rhythms of interest were delta (2-4Hz), theta (4-8Hz), alpha 1 (8-10.5Hz), alpha 2 (10.5-13Hz), beta 1 (13-20Hz), and beta 2 (20-30Hz). Low resolution electromagnetic source tomography (LORETA) was used for EEG source analysis. As expected, we observed that alpha 1 sources in parietal, occipital, and temporal areas were lower in amplitude in the AD and MCI subjects than in the Nold subjects, whereas the amplitude of wide delta sources was higher in the AD than in the Nold and MCI subjects. As novel results, the amplitude of parietal, occipital, and temporal alpha 1 sources was higher in the MCI V+ (high vascular load; N=42; MMSE=26) than MCI V- group (low vascular load; N=37; MMSE=26.7). Furthermore, a weak but significant (p<0.05) positive statistical correlation was found between the parietal alpha 1 sources and the score of Wahlund scale across all MCI subjects (i.e. the more severe white-matter lesions, the higher parietal alpha source power). The present results are in line with the additive model of cognitive impairment postulating that this arises as the sum of neurodegenerative and cerebrovascular lesions. SN - 0028-3932 UR - https://www.unboundmedicine.com/medline/citation/18440574/White_matter_vascular_lesions_correlate_with_alpha_EEG_sources_in_mild_cognitive_impairment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3932(08)00121-8 DB - PRIME DP - Unbound Medicine ER -