Tags

Type your tag names separated by a space and hit enter

Prior chronic nicotine impairs cued fear extinction but enhances contextual fear conditioning in rats.
Neuroscience. 2008 Jun 02; 153(4):935-43.N

Abstract

Clinical observations have shown a link for the high comorbid rate between smoking and psychiatric disorders, including anxiety disorders. However, little is known about the neural mechanism underlying the progression from nicotine dependence to an anxiety disorder. A deficit in fear extinction in general is considered to contribute to anxiety disorders. The aim of the present study is to investigate the effects of chronic nicotine on fear extinction in rats. Rats were administrated s.c. nicotine twice per day for 14 days. Two weeks after the last injection rats received a cued or contextual fear conditioning session. Twenty-four hours and 48 h after conditioning, rats received an extinction training session and an extinction test session, respectively. Percent freezing was assessed during all phases of training. In the cued task, prior chronic nicotine did not affect the acquisition of fear response or the within-session fear extinction, but impaired the between-session fear extinction. In the contextual task, the same nicotine treatment schedule did not affect the acquisition of fear response or the within- and between-session fear extinction, but enhanced the retention of fear conditioning. This prior chronic nicotine-induced deficit in cued fear extinction and/or enhanced fear to context may be one of the critical components that contribute to the progression from nicotine dependence to an anxiety disorder.

Authors+Show Affiliations

Department of Physiology, College of Medicine, University of South China, Hengyang, Hunan, PR China. tsw.neuro@126.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18440720

Citation

Tian, S, et al. "Prior Chronic Nicotine Impairs Cued Fear Extinction but Enhances Contextual Fear Conditioning in Rats." Neuroscience, vol. 153, no. 4, 2008, pp. 935-43.
Tian S, Gao J, Han L, et al. Prior chronic nicotine impairs cued fear extinction but enhances contextual fear conditioning in rats. Neuroscience. 2008;153(4):935-43.
Tian, S., Gao, J., Han, L., Fu, J., Li, C., & Li, Z. (2008). Prior chronic nicotine impairs cued fear extinction but enhances contextual fear conditioning in rats. Neuroscience, 153(4), 935-43. https://doi.org/10.1016/j.neuroscience.2008.03.005
Tian S, et al. Prior Chronic Nicotine Impairs Cued Fear Extinction but Enhances Contextual Fear Conditioning in Rats. Neuroscience. 2008 Jun 2;153(4):935-43. PubMed PMID: 18440720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prior chronic nicotine impairs cued fear extinction but enhances contextual fear conditioning in rats. AU - Tian,S, AU - Gao,J, AU - Han,L, AU - Fu,J, AU - Li,C, AU - Li,Z, Y1 - 2008/03/08/ PY - 2007/10/14/received PY - 2008/03/03/revised PY - 2008/03/03/accepted PY - 2008/4/29/pubmed PY - 2008/10/9/medline PY - 2008/4/29/entrez SP - 935 EP - 43 JF - Neuroscience JO - Neuroscience VL - 153 IS - 4 N2 - Clinical observations have shown a link for the high comorbid rate between smoking and psychiatric disorders, including anxiety disorders. However, little is known about the neural mechanism underlying the progression from nicotine dependence to an anxiety disorder. A deficit in fear extinction in general is considered to contribute to anxiety disorders. The aim of the present study is to investigate the effects of chronic nicotine on fear extinction in rats. Rats were administrated s.c. nicotine twice per day for 14 days. Two weeks after the last injection rats received a cued or contextual fear conditioning session. Twenty-four hours and 48 h after conditioning, rats received an extinction training session and an extinction test session, respectively. Percent freezing was assessed during all phases of training. In the cued task, prior chronic nicotine did not affect the acquisition of fear response or the within-session fear extinction, but impaired the between-session fear extinction. In the contextual task, the same nicotine treatment schedule did not affect the acquisition of fear response or the within- and between-session fear extinction, but enhanced the retention of fear conditioning. This prior chronic nicotine-induced deficit in cued fear extinction and/or enhanced fear to context may be one of the critical components that contribute to the progression from nicotine dependence to an anxiety disorder. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/18440720/Prior_chronic_nicotine_impairs_cued_fear_extinction_but_enhances_contextual_fear_conditioning_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(08)00362-X DB - PRIME DP - Unbound Medicine ER -