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In vivo evaluation of anti-oxidant and anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models.
J Ethnopharmacol. 2008 Jun 19; 118(1):21-5.JE

Abstract

AIM OF THE STUDY

Diabetes is known to involve oxidative stress and changes in lipid metabolism. Many secondary plant metabolites have been shown to possess antioxidant activities, improving the effects of oxidative stress due to diabetes. The present study was aimed to evaluate the effect of water extract of Annona squamosa leaves on antioxidant enzymes and lipid profile of animal models of type 2, non-insulin dependent diabetes mellitus (NIDDM).

MATERIAL AND METHODS

The plant material was extracted with boiling water for 2 h. Albino Wistar rats (n=24) were divided into four groups. Diabetes was induced by streptozotocin injection (ip) at a dose of 50 mg/kg. Animals of treated groups were given the dose of 350 mg/kg of the extract. The excised rat tissues were rinsed in ice-cold saline, blotted dry and weighed.

RESULTS AND CONCLUSIONS

The results clearly suggest that the water extract of Annona squamosa leaves possessed antioxidant activity as shown by increased activities of scavenging enzymes, catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), glutathione reductase (GR) and glutathione-s-transferase (GST) and decrease in malondialdehyde levels present in various tissues. Administration of the extract also improved the lipid profile of the treated groups indicating thereby that the high levels of triglyceride and total cholesterol associated with diabetes can also be significantly managed with the extract.

Authors+Show Affiliations

Dr BR Ambedkar Center for Biomedical Research, University of Delhi, Delhi, India. mayraj1@rediffmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18440739

Citation

Gupta, Rajesh Kumar, et al. "In Vivo Evaluation of Anti-oxidant and Anti-lipidimic Potential of Annona Squamosa Aqueous Extract in Type 2 Diabetic Models." Journal of Ethnopharmacology, vol. 118, no. 1, 2008, pp. 21-5.
Gupta RK, Kesari AN, Diwakar S, et al. In vivo evaluation of anti-oxidant and anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models. J Ethnopharmacol. 2008;118(1):21-5.
Gupta, R. K., Kesari, A. N., Diwakar, S., Tyagi, A., Tandon, V., Chandra, R., & Watal, G. (2008). In vivo evaluation of anti-oxidant and anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models. Journal of Ethnopharmacology, 118(1), 21-5. https://doi.org/10.1016/j.jep.2008.03.008
Gupta RK, et al. In Vivo Evaluation of Anti-oxidant and Anti-lipidimic Potential of Annona Squamosa Aqueous Extract in Type 2 Diabetic Models. J Ethnopharmacol. 2008 Jun 19;118(1):21-5. PubMed PMID: 18440739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo evaluation of anti-oxidant and anti-lipidimic potential of Annona squamosa aqueous extract in Type 2 diabetic models. AU - Gupta,Rajesh Kumar, AU - Kesari,Achyut Narayan, AU - Diwakar,Sandhya, AU - Tyagi,Ameetabh, AU - Tandon,Vibha, AU - Chandra,Ramesh, AU - Watal,Geeta, Y1 - 2008/03/19/ PY - 2005/07/27/received PY - 2008/02/22/revised PY - 2008/03/03/accepted PY - 2008/4/29/pubmed PY - 2008/11/11/medline PY - 2008/4/29/entrez SP - 21 EP - 5 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 118 IS - 1 N2 - AIM OF THE STUDY: Diabetes is known to involve oxidative stress and changes in lipid metabolism. Many secondary plant metabolites have been shown to possess antioxidant activities, improving the effects of oxidative stress due to diabetes. The present study was aimed to evaluate the effect of water extract of Annona squamosa leaves on antioxidant enzymes and lipid profile of animal models of type 2, non-insulin dependent diabetes mellitus (NIDDM). MATERIAL AND METHODS: The plant material was extracted with boiling water for 2 h. Albino Wistar rats (n=24) were divided into four groups. Diabetes was induced by streptozotocin injection (ip) at a dose of 50 mg/kg. Animals of treated groups were given the dose of 350 mg/kg of the extract. The excised rat tissues were rinsed in ice-cold saline, blotted dry and weighed. RESULTS AND CONCLUSIONS: The results clearly suggest that the water extract of Annona squamosa leaves possessed antioxidant activity as shown by increased activities of scavenging enzymes, catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), glutathione reductase (GR) and glutathione-s-transferase (GST) and decrease in malondialdehyde levels present in various tissues. Administration of the extract also improved the lipid profile of the treated groups indicating thereby that the high levels of triglyceride and total cholesterol associated with diabetes can also be significantly managed with the extract. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18440739/In_vivo_evaluation_of_anti_oxidant_and_anti_lipidimic_potential_of_Annona_squamosa_aqueous_extract_in_Type_2_diabetic_models_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00151-7 DB - PRIME DP - Unbound Medicine ER -