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Patterns of alcohol (especially wine) consumption and breast cancer risk: a case-control study among a population in Southern France.

Abstract

PURPOSE

The association between alcohol consumption and breast cancer has been largely investigated, but few studies have investigated the effects of average intake when the pattern of drinking is taken into account. We sought to examine the association between drinking pattern of alcoholic beverages, particularly wine, and breast cancer using different statistical approaches.

METHODS

Our study included 437 cases of breast cancer, newly diagnosed in the period 2002-2004, and 922 residence- and age-matched controls.

RESULTS

Women who had an average consumption of less than 1.5 drinks per day had a lower risk (odds ratio [OR] = 0.58, 95% confidence interval [CI] = 0.34-0.97) when compared with nondrinkers. This protective effect was due substantially to wine consumption since the proportion of regular wine drinkers is predominant in our study population. Furthermore, women who consumed between 10 and 12 g/d of wine had a lower risk (OR = 0.51; 95% CI = 0.30-0.91) when compared with non-wine drinkers. Above 12 g per day of wine consumption, the risk of breast cancer increased, but the association was nonsignificant.

CONCLUSIONS

Although no association between the pattern of total alcohol consumption and breast cancer was found, the type of alcoholic beverage seemed to play an important role in this association. Our results support the hypothesis that there is a threshold effect that risk decreased or was not modified for consumption under a certain threshold. Above that threshold, risk increased, however. The drinking pattern of each type of specific beverage, especially wine, seems important in terms of alcohol-breast cancer association. Low and regular wine consumption does not increase breast cancer risk.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Laboratoire de Biostatistiques et d'Epidémiologie- Institut Universitaire de Recherche Clinique,Montpellier, France. bessaoud@iurc.montp.inserm.fr

    Source

    Annals of epidemiology 18:6 2008 Jun pg 467-75

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Alcohol Drinking
    Breast Neoplasms
    Case-Control Studies
    Dose-Response Relationship, Drug
    Female
    France
    Humans
    Middle Aged
    Risk Factors
    Statistics as Topic
    Wine

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18440826

    Citation

    Bessaoud, F, and J P. Daurès. "Patterns of Alcohol (especially Wine) Consumption and Breast Cancer Risk: a Case-control Study Among a Population in Southern France." Annals of Epidemiology, vol. 18, no. 6, 2008, pp. 467-75.
    Bessaoud F, Daurès JP. Patterns of alcohol (especially wine) consumption and breast cancer risk: a case-control study among a population in Southern France. Ann Epidemiol. 2008;18(6):467-75.
    Bessaoud, F., & Daurès, J. P. (2008). Patterns of alcohol (especially wine) consumption and breast cancer risk: a case-control study among a population in Southern France. Annals of Epidemiology, 18(6), pp. 467-75. doi:10.1016/j.annepidem.2008.02.001.
    Bessaoud F, Daurès JP. Patterns of Alcohol (especially Wine) Consumption and Breast Cancer Risk: a Case-control Study Among a Population in Southern France. Ann Epidemiol. 2008;18(6):467-75. PubMed PMID: 18440826.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Patterns of alcohol (especially wine) consumption and breast cancer risk: a case-control study among a population in Southern France. AU - Bessaoud,F, AU - Daurès,J P, Y1 - 2008/04/28/ PY - 2007/08/21/received PY - 2008/02/01/revised PY - 2008/02/02/accepted PY - 2008/4/29/pubmed PY - 2008/8/6/medline PY - 2008/4/29/entrez SP - 467 EP - 75 JF - Annals of epidemiology JO - Ann Epidemiol VL - 18 IS - 6 N2 - PURPOSE: The association between alcohol consumption and breast cancer has been largely investigated, but few studies have investigated the effects of average intake when the pattern of drinking is taken into account. We sought to examine the association between drinking pattern of alcoholic beverages, particularly wine, and breast cancer using different statistical approaches. METHODS: Our study included 437 cases of breast cancer, newly diagnosed in the period 2002-2004, and 922 residence- and age-matched controls. RESULTS: Women who had an average consumption of less than 1.5 drinks per day had a lower risk (odds ratio [OR] = 0.58, 95% confidence interval [CI] = 0.34-0.97) when compared with nondrinkers. This protective effect was due substantially to wine consumption since the proportion of regular wine drinkers is predominant in our study population. Furthermore, women who consumed between 10 and 12 g/d of wine had a lower risk (OR = 0.51; 95% CI = 0.30-0.91) when compared with non-wine drinkers. Above 12 g per day of wine consumption, the risk of breast cancer increased, but the association was nonsignificant. CONCLUSIONS: Although no association between the pattern of total alcohol consumption and breast cancer was found, the type of alcoholic beverage seemed to play an important role in this association. Our results support the hypothesis that there is a threshold effect that risk decreased or was not modified for consumption under a certain threshold. Above that threshold, risk increased, however. The drinking pattern of each type of specific beverage, especially wine, seems important in terms of alcohol-breast cancer association. Low and regular wine consumption does not increase breast cancer risk. SN - 1873-2585 UR - https://www.unboundmedicine.com/medline/citation/18440826/Patterns_of_alcohol__especially_wine__consumption_and_breast_cancer_risk:_a_case_control_study_among_a_population_in_Southern_France_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(08)00028-8 DB - PRIME DP - Unbound Medicine ER -