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Nicotinic acetylcholine receptors of the ventral tegmental area are involved in mediating morphine-state-dependent learning.
Neurobiol Learn Mem. 2008 Jul; 90(1):255-60.NL

Abstract

In the present study, the possible role of nicotinic acetylcholine (nACh) receptors of the ventral tegmental area (VTA) on morphine-state-dependent learning was studied in adult male Wistar rats. As a model of memory, a step-through type passive avoidance task was used. All animals were bilaterally implanted with chronic cannulae in the VTA, trained using a 1mA foot shock, and tested 24h after training to measure step-through latency. Post-training subcutaneous (s.c.) injection of morphine (0.5-5mg/kg) dose-dependently reduced the step-through latency, showing morphine-induced amnesia. Amnesia induced by post-training morphine was significantly reversed by pre-test administration of morphine (2.5-5mg/kg, s.c.) and induced morphine-state-dependent learning. Pre-test injection of nicotine (0.25-1microg/rat) into the VTA plus an ineffective dose of morphine (0.5mg/kg) significantly restored the memory retrieval. It should be noted that pre-test intra-VTA injection of the same doses of nicotine (0.25-1microg/rat) alone cannot affect memory retention. Furthermore, pre-test intra-VTA injection of the nicotinic acetylcholine receptor antagonist, mecamylamine (1-3microg/rat) 5min before the administration of morphine (5mg/kg, s.c.) dose-dependently inhibited morphine-state-dependent learning. Pre-test injection of the higher dose of mecamylamine (3microg/rat) into the VTA by itself decreased the step-through latency and induced amnesia. On the other hand, mecamylamine (0.5 and 1microg/rat, intra-VTA) reversed the effect of nicotine on morphine response. The results indicate that nACh receptors in the VTA participate in the modulation of morphine-induced recovery of memory, on the test day.

Authors+Show Affiliations

Department of Animal Bioliogy, School of Biology, College of Science, University of Tehran, P. O. Box 4155-6455, Tehran, Iran. rezayof@khayam.ut.ac.irNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18440834

Citation

Rezayof, Ameneh, et al. "Nicotinic Acetylcholine Receptors of the Ventral Tegmental Area Are Involved in Mediating Morphine-state-dependent Learning." Neurobiology of Learning and Memory, vol. 90, no. 1, 2008, pp. 255-60.
Rezayof A, Darbandi N, Zarrindast MR. Nicotinic acetylcholine receptors of the ventral tegmental area are involved in mediating morphine-state-dependent learning. Neurobiol Learn Mem. 2008;90(1):255-60.
Rezayof, A., Darbandi, N., & Zarrindast, M. R. (2008). Nicotinic acetylcholine receptors of the ventral tegmental area are involved in mediating morphine-state-dependent learning. Neurobiology of Learning and Memory, 90(1), 255-60. https://doi.org/10.1016/j.nlm.2008.03.004
Rezayof A, Darbandi N, Zarrindast MR. Nicotinic Acetylcholine Receptors of the Ventral Tegmental Area Are Involved in Mediating Morphine-state-dependent Learning. Neurobiol Learn Mem. 2008;90(1):255-60. PubMed PMID: 18440834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nicotinic acetylcholine receptors of the ventral tegmental area are involved in mediating morphine-state-dependent learning. AU - Rezayof,Ameneh, AU - Darbandi,Niloufar, AU - Zarrindast,Mohammad-Reza, Y1 - 2008/04/28/ PY - 2008/02/04/received PY - 2008/03/15/revised PY - 2008/03/17/accepted PY - 2008/4/29/pubmed PY - 2008/9/4/medline PY - 2008/4/29/entrez SP - 255 EP - 60 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 90 IS - 1 N2 - In the present study, the possible role of nicotinic acetylcholine (nACh) receptors of the ventral tegmental area (VTA) on morphine-state-dependent learning was studied in adult male Wistar rats. As a model of memory, a step-through type passive avoidance task was used. All animals were bilaterally implanted with chronic cannulae in the VTA, trained using a 1mA foot shock, and tested 24h after training to measure step-through latency. Post-training subcutaneous (s.c.) injection of morphine (0.5-5mg/kg) dose-dependently reduced the step-through latency, showing morphine-induced amnesia. Amnesia induced by post-training morphine was significantly reversed by pre-test administration of morphine (2.5-5mg/kg, s.c.) and induced morphine-state-dependent learning. Pre-test injection of nicotine (0.25-1microg/rat) into the VTA plus an ineffective dose of morphine (0.5mg/kg) significantly restored the memory retrieval. It should be noted that pre-test intra-VTA injection of the same doses of nicotine (0.25-1microg/rat) alone cannot affect memory retention. Furthermore, pre-test intra-VTA injection of the nicotinic acetylcholine receptor antagonist, mecamylamine (1-3microg/rat) 5min before the administration of morphine (5mg/kg, s.c.) dose-dependently inhibited morphine-state-dependent learning. Pre-test injection of the higher dose of mecamylamine (3microg/rat) into the VTA by itself decreased the step-through latency and induced amnesia. On the other hand, mecamylamine (0.5 and 1microg/rat, intra-VTA) reversed the effect of nicotine on morphine response. The results indicate that nACh receptors in the VTA participate in the modulation of morphine-induced recovery of memory, on the test day. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/18440834/Nicotinic_acetylcholine_receptors_of_the_ventral_tegmental_area_are_involved_in_mediating_morphine_state_dependent_learning_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(08)00039-7 DB - PRIME DP - Unbound Medicine ER -