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Acute effects of microcystins MC-LR and MC-RR on acid and alkaline phosphatase activities and pathological changes in intraperitoneally exposed tilapia fish (Oreochromis sp.).
Toxicol Pathol. 2008 Apr; 36(3):449-58.TP

Abstract

Microcystins (MC) are frequently present in cyanobacterial blooms in rivers and lakes, increasing the risk of toxicity to both animals and humans. There more than eighty reported microcystins, and the present study was undertaken to determine whether MC-LR and MC-RR can induce different enzyme alterations and histopathological changes in tilapia fish (Oreochromis sp.) exposed to a single intraperitoneal (i.p.) injection of the pure standards (MC-LR and MC-RR) at a dose of 500 mug/kg; the tilapia fish were then observed for seven days. The two MC variants caused significant changes in the activities of acid and alkaline phosphatases (ACP and ALP) in vital organs, showing a different response pattern. The livers and kidneys of fish injected with MC-LR were particularly affected. MC-RR induced a very pronounced increase of ACP in the kidney and a significant increase of ALP in the liver. Both MC variants caused pathological lesions in hepatic tissues, such as megalocytosis, necrotic process, and microvesicular steatosis, particularly in fish treated with MC-LR, and degenerative renal changes, glomerulopathy, were more severe in tilapias exposed to MC-RR. In addition, both microcystins also caused significant myopathy in the heart. In contrast, the gills did not show any change in enzyme activity or histopathological injury.

Authors+Show Affiliations

Area de Toxicología, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18441257

Citation

Atencio, Loyda, et al. "Acute Effects of Microcystins MC-LR and MC-RR On Acid and Alkaline Phosphatase Activities and Pathological Changes in Intraperitoneally Exposed Tilapia Fish (Oreochromis Sp.)." Toxicologic Pathology, vol. 36, no. 3, 2008, pp. 449-58.
Atencio L, Moreno I, Prieto AI, et al. Acute effects of microcystins MC-LR and MC-RR on acid and alkaline phosphatase activities and pathological changes in intraperitoneally exposed tilapia fish (Oreochromis sp.). Toxicol Pathol. 2008;36(3):449-58.
Atencio, L., Moreno, I., Prieto, A. I., Moyano, R., Molina, A. M., & Cameán, A. M. (2008). Acute effects of microcystins MC-LR and MC-RR on acid and alkaline phosphatase activities and pathological changes in intraperitoneally exposed tilapia fish (Oreochromis sp.). Toxicologic Pathology, 36(3), 449-58. https://doi.org/10.1177/0192623308315356
Atencio L, et al. Acute Effects of Microcystins MC-LR and MC-RR On Acid and Alkaline Phosphatase Activities and Pathological Changes in Intraperitoneally Exposed Tilapia Fish (Oreochromis Sp.). Toxicol Pathol. 2008;36(3):449-58. PubMed PMID: 18441257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute effects of microcystins MC-LR and MC-RR on acid and alkaline phosphatase activities and pathological changes in intraperitoneally exposed tilapia fish (Oreochromis sp.). AU - Atencio,Loyda, AU - Moreno,Isabel, AU - Prieto,Ana I, AU - Moyano,Rosario, AU - Molina,Ana M, AU - Cameán,Ana M, Y1 - 2008/04/25/ PY - 2008/4/29/pubmed PY - 2008/8/6/medline PY - 2008/4/29/entrez SP - 449 EP - 58 JF - Toxicologic pathology JO - Toxicol Pathol VL - 36 IS - 3 N2 - Microcystins (MC) are frequently present in cyanobacterial blooms in rivers and lakes, increasing the risk of toxicity to both animals and humans. There more than eighty reported microcystins, and the present study was undertaken to determine whether MC-LR and MC-RR can induce different enzyme alterations and histopathological changes in tilapia fish (Oreochromis sp.) exposed to a single intraperitoneal (i.p.) injection of the pure standards (MC-LR and MC-RR) at a dose of 500 mug/kg; the tilapia fish were then observed for seven days. The two MC variants caused significant changes in the activities of acid and alkaline phosphatases (ACP and ALP) in vital organs, showing a different response pattern. The livers and kidneys of fish injected with MC-LR were particularly affected. MC-RR induced a very pronounced increase of ACP in the kidney and a significant increase of ALP in the liver. Both MC variants caused pathological lesions in hepatic tissues, such as megalocytosis, necrotic process, and microvesicular steatosis, particularly in fish treated with MC-LR, and degenerative renal changes, glomerulopathy, were more severe in tilapias exposed to MC-RR. In addition, both microcystins also caused significant myopathy in the heart. In contrast, the gills did not show any change in enzyme activity or histopathological injury. SN - 1533-1601 UR - https://www.unboundmedicine.com/medline/citation/18441257/Acute_effects_of_microcystins_MC_LR_and_MC_RR_on_acid_and_alkaline_phosphatase_activities_and_pathological_changes_in_intraperitoneally_exposed_tilapia_fish__Oreochromis_sp___ L2 - https://journals.sagepub.com/doi/10.1177/0192623308315356?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -