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Efficacy of long-term continuous subcutaneous apomorphine infusion in advanced Parkinson's disease with motor fluctuations: a multicenter study.
Mov Disord. 2008 Jun 15; 23(8):1130-6.MD

Abstract

Continuous subcutaneous apomorphine infusion (CSAI) is, at present, an alternative option for advanced Parkinson's disease (PD) with motor fluctuations. We studied the evolution of patients with PD and severe motor fluctuations long-term treated with CSAI. We reviewed data from 82 patients with PD (mean age, 67 +/- 11.07; disease duration, 14.39 +/- 5.7 years) and severe motor fluctuations referred to 35 tertiary hospitals in Spain. These patients were long-term treated (for at least 3 months) with CSAI and tolerated the procedure without serious side effects. We compared the baseline data of these 82 patients (before CSAI) with those obtained from the last follow-up visit of each patient. The mean follow-up of CSAI was 19.93 +/- 16.3 months. Mean daily dose of CSAI was 72.00 +/- 21.38 mg run over 14.05 +/- 1.81 hours. We found a statistically significant reduction in off-hours, according to self-scoring diaries (6.64 +/- 3.09 vs. 1.36 +/- 1.42 hours/day, P < 0.0001), total and motor UPDRS scores (P < 0.0001), dyskinesia severity (P < 0.0006), and equivalent dose of antiparkinsonian therapy (1,405 +/- 536.7 vs. 800.1 +/- 472.9 mg of levodopa equivalent units P < 0.0001). CSAI is an effective option for patients with PD and severe fluctuations, poorly controlled by conventional oral drug treatment.

Authors+Show Affiliations

Department of Neurology, Fundación Jiménez Díaz, Madrid, Spain. pgarcia@fjd.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

18442107

Citation

García Ruiz, Pedro J., et al. "Efficacy of Long-term Continuous Subcutaneous Apomorphine Infusion in Advanced Parkinson's Disease With Motor Fluctuations: a Multicenter Study." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 23, no. 8, 2008, pp. 1130-6.
García Ruiz PJ, Sesar Ignacio A, Ares Pensado B, et al. Efficacy of long-term continuous subcutaneous apomorphine infusion in advanced Parkinson's disease with motor fluctuations: a multicenter study. Mov Disord. 2008;23(8):1130-6.
García Ruiz, P. J., Sesar Ignacio, A., Ares Pensado, B., Castro García, A., Alonso Frech, F., Alvarez López, M., Arbelo González, J., Baiges Octavio, J., Burguera Hernández, J. A., Calopa Garriga, M., Campos Blanco, D., Castaño García, B., Carballo Cordero, M., Chacón Peña, J., Espino Ibáñez, A., Gorospe Onisalde, A., Giménez-Roldán, S., Granés Ibáñez, P., Hernández Vara, J., ... Zamarbide Capdepon, I. (2008). Efficacy of long-term continuous subcutaneous apomorphine infusion in advanced Parkinson's disease with motor fluctuations: a multicenter study. Movement Disorders : Official Journal of the Movement Disorder Society, 23(8), 1130-6. https://doi.org/10.1002/mds.22063
García Ruiz PJ, et al. Efficacy of Long-term Continuous Subcutaneous Apomorphine Infusion in Advanced Parkinson's Disease With Motor Fluctuations: a Multicenter Study. Mov Disord. 2008 Jun 15;23(8):1130-6. PubMed PMID: 18442107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of long-term continuous subcutaneous apomorphine infusion in advanced Parkinson's disease with motor fluctuations: a multicenter study. AU - García Ruiz,Pedro J, AU - Sesar Ignacio,Angel, AU - Ares Pensado,Begoña, AU - Castro García,Alfonso, AU - Alonso Frech,Fernando, AU - Alvarez López,Mercedes, AU - Arbelo González,José, AU - Baiges Octavio,Joan, AU - Burguera Hernández,Juan Andrés, AU - Calopa Garriga,Matilde, AU - Campos Blanco,Dulce, AU - Castaño García,Belén, AU - Carballo Cordero,Manuel, AU - Chacón Peña,José, AU - Espino Ibáñez,Anna, AU - Gorospe Onisalde,Aránzazu, AU - Giménez-Roldán,Santiago, AU - Granés Ibáñez,Pilar, AU - Hernández Vara,Jorge, AU - Ibáñez Alonso,Ramón, AU - Jiménez Jiménez,Félix Javier, AU - Krupinski,Jerzy, AU - Kulisevsky Bojarsky,Jaime, AU - Legarda Ramírez,Inés, AU - Lezcano García,Elena, AU - Martínez-Castrillo,Juan Carlos, AU - Mateo González,Dolores, AU - Miquel Rodríguez,Francesc, AU - Mir,Pablo, AU - Muñoz Fargas,Elena, AU - Obeso Inchausti,José, AU - Olivares Romero,Jesús, AU - Olivé Plana,José, AU - Otermin Vallejo,Pilar, AU - Pascual Sedano,Berta, AU - Pérez de Colosía Rama,Víctor, AU - Pérez López-Fraile,Isabel, AU - Planas Comes,Albert, AU - Puente Periz,Víctor, AU - Rodríguez Oroz,María Cruz, AU - Sevillano García,Dolores, AU - Solís Pérez,Pilar, AU - Suárez Muñoz,José, AU - Vaamonde Gamo,Julia, AU - Valero Merino,Caridad, AU - Valldeoriola Serra,Francesc, AU - Velázquez Pérez,José Miguel, AU - Yáñez Baña,Rosa, AU - Zamarbide Capdepon,Ivana, PY - 2008/4/30/pubmed PY - 2008/10/22/medline PY - 2008/4/30/entrez SP - 1130 EP - 6 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 23 IS - 8 N2 - Continuous subcutaneous apomorphine infusion (CSAI) is, at present, an alternative option for advanced Parkinson's disease (PD) with motor fluctuations. We studied the evolution of patients with PD and severe motor fluctuations long-term treated with CSAI. We reviewed data from 82 patients with PD (mean age, 67 +/- 11.07; disease duration, 14.39 +/- 5.7 years) and severe motor fluctuations referred to 35 tertiary hospitals in Spain. These patients were long-term treated (for at least 3 months) with CSAI and tolerated the procedure without serious side effects. We compared the baseline data of these 82 patients (before CSAI) with those obtained from the last follow-up visit of each patient. The mean follow-up of CSAI was 19.93 +/- 16.3 months. Mean daily dose of CSAI was 72.00 +/- 21.38 mg run over 14.05 +/- 1.81 hours. We found a statistically significant reduction in off-hours, according to self-scoring diaries (6.64 +/- 3.09 vs. 1.36 +/- 1.42 hours/day, P < 0.0001), total and motor UPDRS scores (P < 0.0001), dyskinesia severity (P < 0.0006), and equivalent dose of antiparkinsonian therapy (1,405 +/- 536.7 vs. 800.1 +/- 472.9 mg of levodopa equivalent units P < 0.0001). CSAI is an effective option for patients with PD and severe fluctuations, poorly controlled by conventional oral drug treatment. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/18442107/Efficacy_of_long_term_continuous_subcutaneous_apomorphine_infusion_in_advanced_Parkinson's_disease_with_motor_fluctuations:_a_multicenter_study_ L2 - https://doi.org/10.1002/mds.22063 DB - PRIME DP - Unbound Medicine ER -