Tags

Type your tag names separated by a space and hit enter

Parkinson's disease in Arabs: a systematic review.
Mov Disord. 2008 Jul 15; 23(9):1205-10.MD

Abstract

Studies of specific populations have provided invaluable knowledge about Parkinson's disease (PD), especially in the field of genetics. The present report systematically reviews the medical literature on PD in Arabs. Medline and Embase were searched, and 24 article were identified: genetic (n = 17), epidemiological (n = 3), and clinical series (n = 5). Both autosomal dominant and recessive forms of inherited PD are described, associated with four genes (Parkin, PINK1, LRRK2, and PARK9). The G2019S LRRK2 mutation is more common in both familial (37-42%) and apparently sporadic PD (41%) in North African Arabs than in Europeans and North Americans (2-3%). The incidence of PD is reported at 4.5 per 100,000 person-years and reported prevalence at 27 to 43 per 100,000 persons. Hospital-based clinical series suggest that parkinsonism is the commonest movement disorder. Clinical features of PD in Arabs are not significantly different from those reported elsewhere. PD was reported as the cause of dementia in around 7% of Arabs. The majority of studies relate to the role of genes in the etiology of PD in North African Arabs. Further genetic, epidemiological and clinical studies from the majority of Arabic countries may enhance our understanding of PD.

Authors+Show Affiliations

Department of Neurology, Queen Elizabeth Neuroscience Centre, Queen Elizabeth University Hospital, Birmingham, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

18442138

Citation

Benamer, Hani T S., et al. "Parkinson's Disease in Arabs: a Systematic Review." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 23, no. 9, 2008, pp. 1205-10.
Benamer HT, de Silva R, Siddiqui KA, et al. Parkinson's disease in Arabs: a systematic review. Mov Disord. 2008;23(9):1205-10.
Benamer, H. T., de Silva, R., Siddiqui, K. A., & Grosset, D. G. (2008). Parkinson's disease in Arabs: a systematic review. Movement Disorders : Official Journal of the Movement Disorder Society, 23(9), 1205-10. https://doi.org/10.1002/mds.22041
Benamer HT, et al. Parkinson's Disease in Arabs: a Systematic Review. Mov Disord. 2008 Jul 15;23(9):1205-10. PubMed PMID: 18442138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parkinson's disease in Arabs: a systematic review. AU - Benamer,Hani T S, AU - de Silva,Rajith, AU - Siddiqui,Khurram A, AU - Grosset,Donald G, PY - 2008/4/30/pubmed PY - 2009/1/13/medline PY - 2008/4/30/entrez SP - 1205 EP - 10 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 23 IS - 9 N2 - Studies of specific populations have provided invaluable knowledge about Parkinson's disease (PD), especially in the field of genetics. The present report systematically reviews the medical literature on PD in Arabs. Medline and Embase were searched, and 24 article were identified: genetic (n = 17), epidemiological (n = 3), and clinical series (n = 5). Both autosomal dominant and recessive forms of inherited PD are described, associated with four genes (Parkin, PINK1, LRRK2, and PARK9). The G2019S LRRK2 mutation is more common in both familial (37-42%) and apparently sporadic PD (41%) in North African Arabs than in Europeans and North Americans (2-3%). The incidence of PD is reported at 4.5 per 100,000 person-years and reported prevalence at 27 to 43 per 100,000 persons. Hospital-based clinical series suggest that parkinsonism is the commonest movement disorder. Clinical features of PD in Arabs are not significantly different from those reported elsewhere. PD was reported as the cause of dementia in around 7% of Arabs. The majority of studies relate to the role of genes in the etiology of PD in North African Arabs. Further genetic, epidemiological and clinical studies from the majority of Arabic countries may enhance our understanding of PD. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/18442138/Parkinson's_disease_in_Arabs:_a_systematic_review_ L2 - https://doi.org/10.1002/mds.22041 DB - PRIME DP - Unbound Medicine ER -