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Antiproliferative oleanane saponins from Meryta denhamii.
J Nat Prod. 2008 Jun; 71(6):1000-4.JN

Abstract

Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Cioffi G
Dipartimento di Scienze Farmaceutiche, Universitaàdi Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy.
Dal Piaz F
No affiliation info available
Vassallo A
No affiliation info available
Venturella F
No affiliation info available
De Caprariis P
No affiliation info available
De Simone F
No affiliation info available
De Tommasi N
No affiliation info available

MeSH

AnimalsAntineoplastic Agents, PhytogenicAraliaceaeDrug Screening Assays, AntitumorHumansItalyMiceMolecular StructureNuclear Magnetic Resonance, BiomolecularOleanolic AcidPlants, MedicinalSaponins

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18442289

Citation

Cioffi, Giuseppina, et al. "Antiproliferative Oleanane Saponins From Meryta Denhamii." Journal of Natural Products, vol. 71, no. 6, 2008, pp. 1000-4.
Cioffi G, Dal Piaz F, Vassallo A, et al. Antiproliferative oleanane saponins from Meryta denhamii. J Nat Prod. 2008;71(6):1000-4.
Cioffi, G., Dal Piaz, F., Vassallo, A., Venturella, F., De Caprariis, P., De Simone, F., & De Tommasi, N. (2008). Antiproliferative oleanane saponins from Meryta denhamii. Journal of Natural Products, 71(6), 1000-4. https://doi.org/10.1021/np8000464
Cioffi G, et al. Antiproliferative Oleanane Saponins From Meryta Denhamii. J Nat Prod. 2008;71(6):1000-4. PubMed PMID: 18442289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiproliferative oleanane saponins from Meryta denhamii. AU - Cioffi,Giuseppina, AU - Dal Piaz,Fabrizio, AU - Vassallo,Antonio, AU - Venturella,Fabio, AU - De Caprariis,Paolo, AU - De Simone,Francesco, AU - De Tommasi,Nunziatina, Y1 - 2008/04/29/ PY - 2008/4/30/pubmed PY - 2008/9/16/medline PY - 2008/4/30/entrez SP - 1000 EP - 4 JF - Journal of natural products JO - J Nat Prod VL - 71 IS - 6 N2 - Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/18442289/Antiproliferative_oleanane_saponins_from_Meryta_denhamii_ DB - PRIME DP - Unbound Medicine ER -