Tags

Type your tag names separated by a space and hit enter

Myocardial HLA-G reliably indicates a low risk of acute cellular rejection in heart transplant recipients.
J Heart Lung Transplant. 2008 May; 27(5):522-7.JH

Abstract

BACKGROUND

Human leukocyte antigen-G (HLA-G), a non-classical MHC I protein with restricted tissue expression, plays an essential role in immune tolerance and has been negatively associated with acute and chronic rejection after heart transplantation. We assessed myocardial HLA-G expression in adult heart transplant patients in an attempt to determine the value of this protein in identifying patients with a low risk of acute cellular rejection.

METHODS

Two groups of patients were included in this study. Group A (non-rejecting) included 29 patients who had no moderate or severe rejection episodes (ISHLT Grade <2R) post-transplant. Group B (rejecting) included 38 patients with at least two moderate or severe rejection episodes (Grade >or=2R) within a 1-year period. Expression of HLA-G in three myocardial biopsies post-transplant from each patient was determined through immunohistochemical staining.

RESULTS

In Group A, 86% of patients had HLA-G(+) biopsies compared with 11% of patients in Group B (p < 0.001; sensitivity 86%, specificity 87%). Whereas 60% of non-rejecting HLA-G(+) patients had at least two positive biopsies, all rejecting HLA-G(+) patients had only one positive biopsy.

CONCLUSIONS

There is a significant negative association between myocardial HLA-G expression and acute cellular rejection after cardiac transplantation. Detection of HLA-G appears to reliably indicate a low risk of developing moderate or severe allograft rejection and may, subsequently, allow for a reduced immunosuppressive regimen.

Authors+Show Affiliations

Heart Transplant Program, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18442718

Citation

Sheshgiri, Rohit, et al. "Myocardial HLA-G Reliably Indicates a Low Risk of Acute Cellular Rejection in Heart Transplant Recipients." The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation, vol. 27, no. 5, 2008, pp. 522-7.
Sheshgiri R, Rouas-Freiss N, Rao V, et al. Myocardial HLA-G reliably indicates a low risk of acute cellular rejection in heart transplant recipients. J Heart Lung Transplant. 2008;27(5):522-7.
Sheshgiri, R., Rouas-Freiss, N., Rao, V., Butany, J., Ramzy, D., Krawice-Radanne, I., Ross, H. J., Carosella, E. D., & Delgado, D. H. (2008). Myocardial HLA-G reliably indicates a low risk of acute cellular rejection in heart transplant recipients. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation, 27(5), 522-7. https://doi.org/10.1016/j.healun.2008.02.004
Sheshgiri R, et al. Myocardial HLA-G Reliably Indicates a Low Risk of Acute Cellular Rejection in Heart Transplant Recipients. J Heart Lung Transplant. 2008;27(5):522-7. PubMed PMID: 18442718.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Myocardial HLA-G reliably indicates a low risk of acute cellular rejection in heart transplant recipients. AU - Sheshgiri,Rohit, AU - Rouas-Freiss,Nathalie, AU - Rao,Vivek, AU - Butany,Jagdish, AU - Ramzy,Danny, AU - Krawice-Radanne,Irene, AU - Ross,Heather J, AU - Carosella,Edgardo D, AU - Delgado,Diego H, PY - 2007/10/22/received PY - 2008/01/20/revised PY - 2008/02/06/accepted PY - 2008/4/30/pubmed PY - 2008/6/27/medline PY - 2008/4/30/entrez SP - 522 EP - 7 JF - The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation JO - J. Heart Lung Transplant. VL - 27 IS - 5 N2 - BACKGROUND: Human leukocyte antigen-G (HLA-G), a non-classical MHC I protein with restricted tissue expression, plays an essential role in immune tolerance and has been negatively associated with acute and chronic rejection after heart transplantation. We assessed myocardial HLA-G expression in adult heart transplant patients in an attempt to determine the value of this protein in identifying patients with a low risk of acute cellular rejection. METHODS: Two groups of patients were included in this study. Group A (non-rejecting) included 29 patients who had no moderate or severe rejection episodes (ISHLT Grade <2R) post-transplant. Group B (rejecting) included 38 patients with at least two moderate or severe rejection episodes (Grade >or=2R) within a 1-year period. Expression of HLA-G in three myocardial biopsies post-transplant from each patient was determined through immunohistochemical staining. RESULTS: In Group A, 86% of patients had HLA-G(+) biopsies compared with 11% of patients in Group B (p < 0.001; sensitivity 86%, specificity 87%). Whereas 60% of non-rejecting HLA-G(+) patients had at least two positive biopsies, all rejecting HLA-G(+) patients had only one positive biopsy. CONCLUSIONS: There is a significant negative association between myocardial HLA-G expression and acute cellular rejection after cardiac transplantation. Detection of HLA-G appears to reliably indicate a low risk of developing moderate or severe allograft rejection and may, subsequently, allow for a reduced immunosuppressive regimen. SN - 1557-3117 UR - https://www.unboundmedicine.com/medline/citation/18442718/Myocardial_HLA_G_reliably_indicates_a_low_risk_of_acute_cellular_rejection_in_heart_transplant_recipients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-2498(08)00137-X DB - PRIME DP - Unbound Medicine ER -