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Tenotomy procedure alleviates the "slow to see" phenomenon in infantile nystagmus syndrome: model prediction and patient data.
Vision Res. 2008 Jun; 48(12):1409-19.VR

Abstract

Our purpose was to perform a systematic study of the post-four-muscle-tenotomy procedure changes in target acquisition time by comparing predictions from the behavioral ocular motor system (OMS) model and data from infantile nystagmus syndrome (INS) patients. We studied five INS patients who underwent only tenotomy at the enthesis and reattachment at the original insertion of each (previously unoperated) horizontal rectus muscle for their INS treatment. We measured their pre- and post-tenotomy target acquisition changes using data from infrared reflection and high-speed digital video. Three key aspects were calculated and analyzed: the saccadic latency (Ls), the time to target acquisition after the target jump (Lt) and the normalized stimulus time within the cycle. Analyses were performed in MATLAB environment (The MathWorks, Natick, MA) using OMLAB software (OMtools, available from http://www.omlab.org). Model simulations were performed in MATLAB Simulink environment. The model simulation suggested an Lt reduction due to an overall foveation-quality improvement. Consistent with that prediction, improvement in Lt, ranging from approximately 200 ms to approximately 500 ms (average approximately 280 ms), was documented in all five patients post-tenotomy. The Lt improvement was not a result of a reduced Ls. INS patients acquired step-target stimuli faster post-tenotomy. This target acquisition improvement may be due to the elevated foveation quality resulting in less inherent variation in the input to the OMS. A refined behavioral OMS model, with "fast" and "slow" motor neuron pathways and a more physiological plant, successfully predicted this improved visual behavior and again demonstrated its utility in guiding ocular motor research.

Authors+Show Affiliations

Daroff-Dell'Osso Ocular Motility Laboratory, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University, 10701 East Boulevard, Cleveland, OH 44106, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

18442840

Citation

Wang, Z I., and L F. Dell'Osso. "Tenotomy Procedure Alleviates the "slow to See" Phenomenon in Infantile Nystagmus Syndrome: Model Prediction and Patient Data." Vision Research, vol. 48, no. 12, 2008, pp. 1409-19.
Wang ZI, Dell'Osso LF. Tenotomy procedure alleviates the "slow to see" phenomenon in infantile nystagmus syndrome: model prediction and patient data. Vision Res. 2008;48(12):1409-19.
Wang, Z. I., & Dell'Osso, L. F. (2008). Tenotomy procedure alleviates the "slow to see" phenomenon in infantile nystagmus syndrome: model prediction and patient data. Vision Research, 48(12), 1409-19. https://doi.org/10.1016/j.visres.2008.03.007
Wang ZI, Dell'Osso LF. Tenotomy Procedure Alleviates the "slow to See" Phenomenon in Infantile Nystagmus Syndrome: Model Prediction and Patient Data. Vision Res. 2008;48(12):1409-19. PubMed PMID: 18442840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tenotomy procedure alleviates the "slow to see" phenomenon in infantile nystagmus syndrome: model prediction and patient data. AU - Wang,Z I, AU - Dell'Osso,L F, Y1 - 2008/04/28/ PY - 2007/12/21/received PY - 2008/03/12/revised PY - 2008/03/18/accepted PY - 2008/4/30/pubmed PY - 2008/7/11/medline PY - 2008/4/30/entrez SP - 1409 EP - 19 JF - Vision research JO - Vision Res VL - 48 IS - 12 N2 - Our purpose was to perform a systematic study of the post-four-muscle-tenotomy procedure changes in target acquisition time by comparing predictions from the behavioral ocular motor system (OMS) model and data from infantile nystagmus syndrome (INS) patients. We studied five INS patients who underwent only tenotomy at the enthesis and reattachment at the original insertion of each (previously unoperated) horizontal rectus muscle for their INS treatment. We measured their pre- and post-tenotomy target acquisition changes using data from infrared reflection and high-speed digital video. Three key aspects were calculated and analyzed: the saccadic latency (Ls), the time to target acquisition after the target jump (Lt) and the normalized stimulus time within the cycle. Analyses were performed in MATLAB environment (The MathWorks, Natick, MA) using OMLAB software (OMtools, available from http://www.omlab.org). Model simulations were performed in MATLAB Simulink environment. The model simulation suggested an Lt reduction due to an overall foveation-quality improvement. Consistent with that prediction, improvement in Lt, ranging from approximately 200 ms to approximately 500 ms (average approximately 280 ms), was documented in all five patients post-tenotomy. The Lt improvement was not a result of a reduced Ls. INS patients acquired step-target stimuli faster post-tenotomy. This target acquisition improvement may be due to the elevated foveation quality resulting in less inherent variation in the input to the OMS. A refined behavioral OMS model, with "fast" and "slow" motor neuron pathways and a more physiological plant, successfully predicted this improved visual behavior and again demonstrated its utility in guiding ocular motor research. SN - 0042-6989 UR - https://www.unboundmedicine.com/medline/citation/18442840/Tenotomy_procedure_alleviates_the_"slow_to_see"_phenomenon_in_infantile_nystagmus_syndrome:_model_prediction_and_patient_data_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042-6989(08)00149-1 DB - PRIME DP - Unbound Medicine ER -