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Single-molecule and single-nanoparticle SERS: from fundamental mechanisms to biomedical applications.
Chem Soc Rev. 2008 May; 37(5):912-20.CS

Abstract

This tutorial review discusses a new class of colloidal metal nanoparticles that is able to enhance the efficiencies of surface-enhanced Raman scattering (SERS) by as much as 10(14)-10(15) fold. This enormous enhancement allows spectroscopic detection and identification of single molecules located on the nanoparticle surface or at the junction of two particles under ambient conditions. Considerable progress has been made in understanding the enhancement mechanisms, including definitive evidence for the single-molecule origin of fluctuating SERS signals. For applications, SERS nanoparticle tags have been developed based on the use of embedded reporter molecules and a silica or polymer encapsulation layer. The SERS nanoparticle tags are capable of providing detailed spectroscopic information and are much brighter than semiconductor quantum dots in the near-infrared spectral window. These properties have raised new opportunities for multiplexed molecular diagnosis and in vivo Raman spectroscopy and imaging.

Authors+Show Affiliations

Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Suite 2001, Atlanta, GA 30322, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

18443676

Citation

Qian, X-M, and S M. Nie. "Single-molecule and Single-nanoparticle SERS: From Fundamental Mechanisms to Biomedical Applications." Chemical Society Reviews, vol. 37, no. 5, 2008, pp. 912-20.
Qian XM, Nie SM. Single-molecule and single-nanoparticle SERS: from fundamental mechanisms to biomedical applications. Chem Soc Rev. 2008;37(5):912-20.
Qian, X. M., & Nie, S. M. (2008). Single-molecule and single-nanoparticle SERS: from fundamental mechanisms to biomedical applications. Chemical Society Reviews, 37(5), 912-20. https://doi.org/10.1039/b708839f
Qian XM, Nie SM. Single-molecule and Single-nanoparticle SERS: From Fundamental Mechanisms to Biomedical Applications. Chem Soc Rev. 2008;37(5):912-20. PubMed PMID: 18443676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single-molecule and single-nanoparticle SERS: from fundamental mechanisms to biomedical applications. AU - Qian,X-M, AU - Nie,S M, Y1 - 2008/03/26/ PY - 2008/4/30/pubmed PY - 2008/7/19/medline PY - 2008/4/30/entrez SP - 912 EP - 20 JF - Chemical Society reviews JO - Chem Soc Rev VL - 37 IS - 5 N2 - This tutorial review discusses a new class of colloidal metal nanoparticles that is able to enhance the efficiencies of surface-enhanced Raman scattering (SERS) by as much as 10(14)-10(15) fold. This enormous enhancement allows spectroscopic detection and identification of single molecules located on the nanoparticle surface or at the junction of two particles under ambient conditions. Considerable progress has been made in understanding the enhancement mechanisms, including definitive evidence for the single-molecule origin of fluctuating SERS signals. For applications, SERS nanoparticle tags have been developed based on the use of embedded reporter molecules and a silica or polymer encapsulation layer. The SERS nanoparticle tags are capable of providing detailed spectroscopic information and are much brighter than semiconductor quantum dots in the near-infrared spectral window. These properties have raised new opportunities for multiplexed molecular diagnosis and in vivo Raman spectroscopy and imaging. SN - 0306-0012 UR - https://www.unboundmedicine.com/medline/citation/18443676/Single_molecule_and_single_nanoparticle_SERS:_from_fundamental_mechanisms_to_biomedical_applications_ L2 - https://doi.org/10.1039/b708839f DB - PRIME DP - Unbound Medicine ER -