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Single molecule analysis by surfaced-enhanced Raman scattering.
Chem Soc Rev. 2008 May; 37(5):946-54.CS

Abstract

Our main objective in this tutorial review is to provide insight into some of the questions surrounding single molecule detection (SMD) using surface-enhanced Raman scattering (SERS) and surface-enhanced resonance Raman scattering (SERRS). Discovered thirty years ago, SERS is now a powerful analytical tool, strongly tied to plasmonics, a field that encompasses and profits from the optical enhancement found in nanostructures that support localized plasmon excitations. The spectrum of the single molecule carries the quantum fingerprints of the system modulated by the molecule-nanostructure interactions and the electronic resonances that may result under laser excitation. This information is embedded in vibrational band parameters. The dynamics and the molecular environment will affect the bandwidth of the observed Raman bands. In addition, the localized surface plasmon resonances (LSPR) empower the nanostructure with a number of optical properties that will also leave their mark on the observed inelastic scattering process. Therefore, controlling size, shape and the formation of the aggregation state (or fractality) of certain metallic nanostructures becomes a main task for experimental SERS/SERRS. This molecule-nanostructure coupling may, inevitably, lead to spectral fluctuations, increase photobleaching or photochemistry. An attempt is made here to guide the interpretation of this wealth of information when approaching the single molecule regime.

Authors+Show Affiliations

Materials & Surface Science Group, Faculty of Science, University of Windsor, Windsor, ON, Canada N9B 3P4.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18443680

Citation

Pieczonka, Nicholas P W., and Ricardo F. Aroca. "Single Molecule Analysis By Surfaced-enhanced Raman Scattering." Chemical Society Reviews, vol. 37, no. 5, 2008, pp. 946-54.
Pieczonka NP, Aroca RF. Single molecule analysis by surfaced-enhanced Raman scattering. Chem Soc Rev. 2008;37(5):946-54.
Pieczonka, N. P., & Aroca, R. F. (2008). Single molecule analysis by surfaced-enhanced Raman scattering. Chemical Society Reviews, 37(5), 946-54. https://doi.org/10.1039/b709739p
Pieczonka NP, Aroca RF. Single Molecule Analysis By Surfaced-enhanced Raman Scattering. Chem Soc Rev. 2008;37(5):946-54. PubMed PMID: 18443680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Single molecule analysis by surfaced-enhanced Raman scattering. AU - Pieczonka,Nicholas P W, AU - Aroca,Ricardo F, Y1 - 2008/02/27/ PY - 2008/4/30/pubmed PY - 2008/4/30/medline PY - 2008/4/30/entrez SP - 946 EP - 54 JF - Chemical Society reviews JO - Chem Soc Rev VL - 37 IS - 5 N2 - Our main objective in this tutorial review is to provide insight into some of the questions surrounding single molecule detection (SMD) using surface-enhanced Raman scattering (SERS) and surface-enhanced resonance Raman scattering (SERRS). Discovered thirty years ago, SERS is now a powerful analytical tool, strongly tied to plasmonics, a field that encompasses and profits from the optical enhancement found in nanostructures that support localized plasmon excitations. The spectrum of the single molecule carries the quantum fingerprints of the system modulated by the molecule-nanostructure interactions and the electronic resonances that may result under laser excitation. This information is embedded in vibrational band parameters. The dynamics and the molecular environment will affect the bandwidth of the observed Raman bands. In addition, the localized surface plasmon resonances (LSPR) empower the nanostructure with a number of optical properties that will also leave their mark on the observed inelastic scattering process. Therefore, controlling size, shape and the formation of the aggregation state (or fractality) of certain metallic nanostructures becomes a main task for experimental SERS/SERRS. This molecule-nanostructure coupling may, inevitably, lead to spectral fluctuations, increase photobleaching or photochemistry. An attempt is made here to guide the interpretation of this wealth of information when approaching the single molecule regime. SN - 0306-0012 UR - https://www.unboundmedicine.com/medline/citation/18443680/Single_molecule_analysis_by_surfaced_enhanced_Raman_scattering_ L2 - https://doi.org/10.1039/b709739p DB - PRIME DP - Unbound Medicine ER -
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