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A combination of tomato and soy products for men with recurring prostate cancer and rising prostate specific antigen.
Nutr Cancer. 2008; 60(2):145-54.NC

Abstract

Tomato and soy products are hypothesized to reduce the risk of prostate cancer or enhance efficacy of therapy. A study was completed to determine if men with active prostate cancer will adhere to a dietary intervention rich in tomato products and a soy protein supplement men (n = 41) with recurrent, asymptomatic prostate cancer were randomized among 2 groups: Group A (n = 20) consumed tomato products (no soy) for Weeks 0 through 4, targeting a minimum of 25 mg of lycopene/day. Group B (n = 21) consumed soy (no tomatoes) for Weeks 0 through 4, providing 40 g of soy protein/day. For Weeks 4 through 8, all men consumed a combined tomato-rich diet and soy supplements. No grade II through IV toxicities were observed. During Weeks 0 through 4, mean daily lycopene intake for Group A was 43 mg (+/- 15 mg) and mean soy intake for Group B was 39 g (+/- 1 g), remaining similar during Weeks 4 through 8. Serum lycopene increased from 0.72 +/- 0.09 micromol/l to 1.21 +/- 0.10 micromol/l (P < 0.0001) and urinary isoflavone excretion increased from not detectable to 54.1 +/- 5.7 micromol/l (P < 0.05) with 8 wk of diet intervention. Serum prostate-specific antigen decreased between Weeks 0 and 8 for 14 / 41 men (34%). Mean serum vascular endothelial growth factor for the entire group was reduced from 87 to 51 ng/ml (P < 0.05) over 8 wk. In conclusion, prostate cancer patients will consume diets rich in tomato products and soy with excellent compliance and bioavailability of phytochemicals. Further studies combining tomato and soy foods to determine efficacy for prostate cancer prevention or management are encouraged.

Authors+Show Affiliations

The Ohio State University, Columbus, Ohio 43210, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18444145

Citation

Grainger, Elizabeth M., et al. "A Combination of Tomato and Soy Products for Men With Recurring Prostate Cancer and Rising Prostate Specific Antigen." Nutrition and Cancer, vol. 60, no. 2, 2008, pp. 145-54.
Grainger EM, Schwartz SJ, Wang S, et al. A combination of tomato and soy products for men with recurring prostate cancer and rising prostate specific antigen. Nutr Cancer. 2008;60(2):145-54.
Grainger, E. M., Schwartz, S. J., Wang, S., Unlu, N. Z., Boileau, T. W., Ferketich, A. K., Monk, J. P., Gong, M. C., Bahnson, R. R., DeGroff, V. L., & Clinton, S. K. (2008). A combination of tomato and soy products for men with recurring prostate cancer and rising prostate specific antigen. Nutrition and Cancer, 60(2), 145-54. https://doi.org/10.1080/01635580701621338
Grainger EM, et al. A Combination of Tomato and Soy Products for Men With Recurring Prostate Cancer and Rising Prostate Specific Antigen. Nutr Cancer. 2008;60(2):145-54. PubMed PMID: 18444145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A combination of tomato and soy products for men with recurring prostate cancer and rising prostate specific antigen. AU - Grainger,Elizabeth M, AU - Schwartz,Steven J, AU - Wang,Shihua, AU - Unlu,Nuray Z, AU - Boileau,Thomas W-M, AU - Ferketich,Amy K, AU - Monk,J Paul, AU - Gong,Michael C, AU - Bahnson,Robert R, AU - DeGroff,Valerie L, AU - Clinton,Steven K, PY - 2008/4/30/pubmed PY - 2008/8/1/medline PY - 2008/4/30/entrez SP - 145 EP - 54 JF - Nutrition and cancer JO - Nutr Cancer VL - 60 IS - 2 N2 - Tomato and soy products are hypothesized to reduce the risk of prostate cancer or enhance efficacy of therapy. A study was completed to determine if men with active prostate cancer will adhere to a dietary intervention rich in tomato products and a soy protein supplement men (n = 41) with recurrent, asymptomatic prostate cancer were randomized among 2 groups: Group A (n = 20) consumed tomato products (no soy) for Weeks 0 through 4, targeting a minimum of 25 mg of lycopene/day. Group B (n = 21) consumed soy (no tomatoes) for Weeks 0 through 4, providing 40 g of soy protein/day. For Weeks 4 through 8, all men consumed a combined tomato-rich diet and soy supplements. No grade II through IV toxicities were observed. During Weeks 0 through 4, mean daily lycopene intake for Group A was 43 mg (+/- 15 mg) and mean soy intake for Group B was 39 g (+/- 1 g), remaining similar during Weeks 4 through 8. Serum lycopene increased from 0.72 +/- 0.09 micromol/l to 1.21 +/- 0.10 micromol/l (P < 0.0001) and urinary isoflavone excretion increased from not detectable to 54.1 +/- 5.7 micromol/l (P < 0.05) with 8 wk of diet intervention. Serum prostate-specific antigen decreased between Weeks 0 and 8 for 14 / 41 men (34%). Mean serum vascular endothelial growth factor for the entire group was reduced from 87 to 51 ng/ml (P < 0.05) over 8 wk. In conclusion, prostate cancer patients will consume diets rich in tomato products and soy with excellent compliance and bioavailability of phytochemicals. Further studies combining tomato and soy foods to determine efficacy for prostate cancer prevention or management are encouraged. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/18444145/A_combination_of_tomato_and_soy_products_for_men_with_recurring_prostate_cancer_and_rising_prostate_specific_antigen_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635580701621338 DB - PRIME DP - Unbound Medicine ER -