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Exploratory factor analysis of squamous cell carcinoma of the esophagus in Uruguay.
Nutr Cancer 2008; 60(2):188-95NC

Abstract

In the period 1996--2004, a hospital-based, case-control study on diet and risk of squamous cell carcinoma of the esophagus was conducted in Montevideo, Uruguay. The study included 234 cases and 468 controls, frequency matched on age, sex, and residence. Factor analysis (principal components) was used to identify the major food patterns associated with esophageal cancer. The analysis of food groups led to the identification of four patterns, arbitrarily labeled as traditional, healthy, high-fat, and drinker. The traditional pattern was not associated with risk of esophageal carcinoma, whereas the healthy pattern displayed a strong inverse association with this malignancy [odds ratio (OR) 0.29, 95% confidence interval (CI) 0.17-0.48, P value for trend < 0.0001]. Unexpectedly, the high-fat foods diet was also marginally protective (OR 0.60, 95% CI 0.36-1.01, P value for trend = 0.07). On the other hand, the drinker pattern displayed a twofold increase in risk of esophageal carcinoma (OR 2.03, 95% CI 1.17-3.51, P value for trend = 0.01). The present study suggests that factor analysis might contribute to the elucidation of the contribution of diet on human cancer. Because diet represents a complex set of highly correlated exposures, dietary patterns could be more explicative of the etiology of squamous cell carcinoma of the esophagus than the traditional reductionist approach.

Authors+Show Affiliations

Grupo de Epidemiología, Departamento de Anatomía Patológica, Hospital de Clínicas Facultad de Medicina, Montevideo, Uruguay. estefani@adinet.com.uyNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18444150

Citation

De Stefani, Eduardo, et al. "Exploratory Factor Analysis of Squamous Cell Carcinoma of the Esophagus in Uruguay." Nutrition and Cancer, vol. 60, no. 2, 2008, pp. 188-95.
De Stefani E, Boffetta P, Ronco AL, et al. Exploratory factor analysis of squamous cell carcinoma of the esophagus in Uruguay. Nutr Cancer. 2008;60(2):188-95.
De Stefani, E., Boffetta, P., Ronco, A. L., Deneo-Pellegrini, H., Correa, P., Acosta, G., & Mendilaharsu, M. (2008). Exploratory factor analysis of squamous cell carcinoma of the esophagus in Uruguay. Nutrition and Cancer, 60(2), pp. 188-95. doi:10.1080/01635580701630487.
De Stefani E, et al. Exploratory Factor Analysis of Squamous Cell Carcinoma of the Esophagus in Uruguay. Nutr Cancer. 2008;60(2):188-95. PubMed PMID: 18444150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exploratory factor analysis of squamous cell carcinoma of the esophagus in Uruguay. AU - De Stefani,Eduardo, AU - Boffetta,Paolo, AU - Ronco,Alvaro L, AU - Deneo-Pellegrini,Hugo, AU - Correa,Pelayo, AU - Acosta,Giselle, AU - Mendilaharsu,María, PY - 2008/4/30/pubmed PY - 2008/8/1/medline PY - 2008/4/30/entrez SP - 188 EP - 95 JF - Nutrition and cancer JO - Nutr Cancer VL - 60 IS - 2 N2 - In the period 1996--2004, a hospital-based, case-control study on diet and risk of squamous cell carcinoma of the esophagus was conducted in Montevideo, Uruguay. The study included 234 cases and 468 controls, frequency matched on age, sex, and residence. Factor analysis (principal components) was used to identify the major food patterns associated with esophageal cancer. The analysis of food groups led to the identification of four patterns, arbitrarily labeled as traditional, healthy, high-fat, and drinker. The traditional pattern was not associated with risk of esophageal carcinoma, whereas the healthy pattern displayed a strong inverse association with this malignancy [odds ratio (OR) 0.29, 95% confidence interval (CI) 0.17-0.48, P value for trend < 0.0001]. Unexpectedly, the high-fat foods diet was also marginally protective (OR 0.60, 95% CI 0.36-1.01, P value for trend = 0.07). On the other hand, the drinker pattern displayed a twofold increase in risk of esophageal carcinoma (OR 2.03, 95% CI 1.17-3.51, P value for trend = 0.01). The present study suggests that factor analysis might contribute to the elucidation of the contribution of diet on human cancer. Because diet represents a complex set of highly correlated exposures, dietary patterns could be more explicative of the etiology of squamous cell carcinoma of the esophagus than the traditional reductionist approach. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/18444150/Exploratory_factor_analysis_of_squamous_cell_carcinoma_of_the_esophagus_in_Uruguay_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635580701630487 DB - PRIME DP - Unbound Medicine ER -