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Alcohol, tobacco, and diet in relation to esophageal cancer: the Shanghai Cohort Study.

Abstract

Prospective data on environmental exposures, especially with respect to alcohol, tobacco, and diet, in relation to the risk of esophageal cancer in high-risk populations are sparse. We analyzed data from a population-based cohort of 18,244 middle-aged and older men in Shanghai to identify risk factors for esophageal cancer in this high-risk population. The cohort was followed through 2006, and 101 incident esophageal cancer cases were identified. Cox proportional hazards models were used to estimate hazard ratios (HR) and their corresponding 95% confidence intervals (CI) for associations between exposures and esophageal cancer risk. With adjustment for tobacco use and other potential confounders, regular drinkers vs. nondrinkers of alcoholic beverages had a twofold risk of developing esophageal cancer (HR=2.02, 95% CI=1.31-3.12). With adjustment for alcohol and other potential confounders, long-term smokers (40+ yr) vs. nonsmokers of cigarettes showed a twofold risk of developing esophageal cancer (HR=2.06, 95% CI=1.11-3.82). Increased consumption of fruits (including oranges/tangerines), seafood, and milk were found to be protective against the development of esophageal cancer; HRs were decreased by 40-60% for high vs. low consumers after adjustment for cigarette smoking, alcohol drinking, and other confounders.

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  • Authors+Show Affiliations

    ,

    The Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA. fanxx047@umn.edu

    , , ,

    Source

    Nutrition and cancer 60:3 2008 pg 354-63

    MeSH

    Alcohol Drinking
    Animals
    China
    Cohort Studies
    Diet
    Esophageal Neoplasms
    Fruit
    Humans
    Male
    Middle Aged
    Milk
    Proportional Hazards Models
    Risk Assessment
    Risk Factors
    Seafood
    Smoking

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    18444169

    Citation

    Fan, Yunhua, et al. "Alcohol, Tobacco, and Diet in Relation to Esophageal Cancer: the Shanghai Cohort Study." Nutrition and Cancer, vol. 60, no. 3, 2008, pp. 354-63.
    Fan Y, Yuan JM, Wang R, et al. Alcohol, tobacco, and diet in relation to esophageal cancer: the Shanghai Cohort Study. Nutr Cancer. 2008;60(3):354-63.
    Fan, Y., Yuan, J. M., Wang, R., Gao, Y. T., & Yu, M. C. (2008). Alcohol, tobacco, and diet in relation to esophageal cancer: the Shanghai Cohort Study. Nutrition and Cancer, 60(3), pp. 354-63. doi:10.1080/01635580701883011.
    Fan Y, et al. Alcohol, Tobacco, and Diet in Relation to Esophageal Cancer: the Shanghai Cohort Study. Nutr Cancer. 2008;60(3):354-63. PubMed PMID: 18444169.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol, tobacco, and diet in relation to esophageal cancer: the Shanghai Cohort Study. AU - Fan,Yunhua, AU - Yuan,Jian-Min, AU - Wang,Renwei, AU - Gao,Yu-Tang, AU - Yu,Mimi C, PY - 2008/4/30/pubmed PY - 2008/10/22/medline PY - 2008/4/30/entrez SP - 354 EP - 63 JF - Nutrition and cancer JO - Nutr Cancer VL - 60 IS - 3 N2 - Prospective data on environmental exposures, especially with respect to alcohol, tobacco, and diet, in relation to the risk of esophageal cancer in high-risk populations are sparse. We analyzed data from a population-based cohort of 18,244 middle-aged and older men in Shanghai to identify risk factors for esophageal cancer in this high-risk population. The cohort was followed through 2006, and 101 incident esophageal cancer cases were identified. Cox proportional hazards models were used to estimate hazard ratios (HR) and their corresponding 95% confidence intervals (CI) for associations between exposures and esophageal cancer risk. With adjustment for tobacco use and other potential confounders, regular drinkers vs. nondrinkers of alcoholic beverages had a twofold risk of developing esophageal cancer (HR=2.02, 95% CI=1.31-3.12). With adjustment for alcohol and other potential confounders, long-term smokers (40+ yr) vs. nonsmokers of cigarettes showed a twofold risk of developing esophageal cancer (HR=2.06, 95% CI=1.11-3.82). Increased consumption of fruits (including oranges/tangerines), seafood, and milk were found to be protective against the development of esophageal cancer; HRs were decreased by 40-60% for high vs. low consumers after adjustment for cigarette smoking, alcohol drinking, and other confounders. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/18444169/Alcohol_tobacco_and_diet_in_relation_to_esophageal_cancer:_the_Shanghai_Cohort_Study_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635580701883011 DB - PRIME DP - Unbound Medicine ER -