Tags

Type your tag names separated by a space and hit enter

Trends in antimicrobial susceptibility of Gram-negative isolates from a paediatric intensive care unit in Warsaw: results from the MYSTIC programme (1997-2007).
J Antimicrob Chemother. 2008 Aug; 62(2):369-75.JA

Abstract

OBJECTIVES

The Meropenem Yearly Susceptibility Test Information Collection (MYSTIC) programme is a longitudinal global surveillance study to monitor in vitro data on microbial susceptibility in centres that prescribe meropenem. This overview provides data on the susceptibility of Gram-negative bacteria (n = 1300) isolated from clinical specimens of children hospitalized in a paediatric intensive care unit (ICU) during 1997-2007.

METHODS

MICs of meropenem and eight other antibiotics were determined using the CLSI agar dilution method.

RESULTS

Meropenem, imipenem and ciprofloxacin were most active (>90% susceptibility) against the tested isolates. A greater proportion of Pseudomonas aeruginosa isolates was susceptible to meropenem compared with imipenem. Antibiotic susceptibility of Enterobacteriaceae and Acinetobacter baumannii showed an increase in 2007. Only susceptibility of P. aeruginosa to ceftazidime and cefepime increased. The incidence of extended-spectrum beta-lactamase (ESBL) producers among Enterobacteriaceae isolates decreased from 37% in 1997 to 21.8% in 2007, and AmpC beta-lactamase producers decreased from 24.6% to 5.7%. Consumption of cephalosporins remained the same and piperacillin/tazobactam increased 3-fold. During 11 years, despite an increase in carbapenem consumption, meropenem and imipenem have retained excellent activity against the majority of isolates studied.

CONCLUSIONS

The comparison of antibiotic susceptibility of Gram-negative isolates in 1997 and 2007 showed a trend of increase, and the number of beta-lactamase-producing isolates among Enterobacteriaceae showed a trend of decrease possibly related to changes in antibiotic policy.

Authors+Show Affiliations

Department of Clinical Microbiology and Immunology, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland. j.patzer@czd.plNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18445575

Citation

Patzer, Jan A., et al. "Trends in Antimicrobial Susceptibility of Gram-negative Isolates From a Paediatric Intensive Care Unit in Warsaw: Results From the MYSTIC Programme (1997-2007)." The Journal of Antimicrobial Chemotherapy, vol. 62, no. 2, 2008, pp. 369-75.
Patzer JA, Dzierzanowska D, Turner PJ. Trends in antimicrobial susceptibility of Gram-negative isolates from a paediatric intensive care unit in Warsaw: results from the MYSTIC programme (1997-2007). J Antimicrob Chemother. 2008;62(2):369-75.
Patzer, J. A., Dzierzanowska, D., & Turner, P. J. (2008). Trends in antimicrobial susceptibility of Gram-negative isolates from a paediatric intensive care unit in Warsaw: results from the MYSTIC programme (1997-2007). The Journal of Antimicrobial Chemotherapy, 62(2), 369-75. https://doi.org/10.1093/jac/dkn184
Patzer JA, Dzierzanowska D, Turner PJ. Trends in Antimicrobial Susceptibility of Gram-negative Isolates From a Paediatric Intensive Care Unit in Warsaw: Results From the MYSTIC Programme (1997-2007). J Antimicrob Chemother. 2008;62(2):369-75. PubMed PMID: 18445575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trends in antimicrobial susceptibility of Gram-negative isolates from a paediatric intensive care unit in Warsaw: results from the MYSTIC programme (1997-2007). AU - Patzer,Jan A, AU - Dzierzanowska,Danuta, AU - Turner,Philip J, Y1 - 2008/04/28/ PY - 2008/5/1/pubmed PY - 2008/8/13/medline PY - 2008/5/1/entrez SP - 369 EP - 75 JF - The Journal of antimicrobial chemotherapy JO - J. Antimicrob. Chemother. VL - 62 IS - 2 N2 - OBJECTIVES: The Meropenem Yearly Susceptibility Test Information Collection (MYSTIC) programme is a longitudinal global surveillance study to monitor in vitro data on microbial susceptibility in centres that prescribe meropenem. This overview provides data on the susceptibility of Gram-negative bacteria (n = 1300) isolated from clinical specimens of children hospitalized in a paediatric intensive care unit (ICU) during 1997-2007. METHODS: MICs of meropenem and eight other antibiotics were determined using the CLSI agar dilution method. RESULTS: Meropenem, imipenem and ciprofloxacin were most active (>90% susceptibility) against the tested isolates. A greater proportion of Pseudomonas aeruginosa isolates was susceptible to meropenem compared with imipenem. Antibiotic susceptibility of Enterobacteriaceae and Acinetobacter baumannii showed an increase in 2007. Only susceptibility of P. aeruginosa to ceftazidime and cefepime increased. The incidence of extended-spectrum beta-lactamase (ESBL) producers among Enterobacteriaceae isolates decreased from 37% in 1997 to 21.8% in 2007, and AmpC beta-lactamase producers decreased from 24.6% to 5.7%. Consumption of cephalosporins remained the same and piperacillin/tazobactam increased 3-fold. During 11 years, despite an increase in carbapenem consumption, meropenem and imipenem have retained excellent activity against the majority of isolates studied. CONCLUSIONS: The comparison of antibiotic susceptibility of Gram-negative isolates in 1997 and 2007 showed a trend of increase, and the number of beta-lactamase-producing isolates among Enterobacteriaceae showed a trend of decrease possibly related to changes in antibiotic policy. SN - 1460-2091 UR - https://www.unboundmedicine.com/medline/citation/18445575/Trends_in_antimicrobial_susceptibility_of_Gram_negative_isolates_from_a_paediatric_intensive_care_unit_in_Warsaw:_results_from_the_MYSTIC_programme__1997_2007__ L2 - https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/dkn184 DB - PRIME DP - Unbound Medicine ER -