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Mechanisms of extrahepatic vasodilation in portal hypertension.
Gut. 2008 Sep; 57(9):1300-14.Gut

Abstract

In liver cirrhosis, abnormal persistent extrahepatic vasodilation leads to hyperdynamic circulatory dysfunction which essentially contributes to portal hypertension. Since portal hypertension is a major factor in the development of complications in cirrhosis, the mechanisms underlying this vasodilation are of paramount interest. Extensive studies performed in cirrhotic patients and animals revealed that this vasodilation is associated on the one hand with enhanced formation of vasodilators, and on the other hand with vascular hyporesponsiveness to vasoconstrictors. The latter phenomenon has been termed "vascular hypocontractility". It is caused by a combination of different mechanisms and factors described in this review.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Hennenberg M
Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany. Martin.Hennenberg@ukb.uni-bonn.de
Trebicka J
No affiliation info available
Sauerbruch T
No affiliation info available
Heller J
No affiliation info available

MeSH

Cannabinoid Receptor ModulatorsHumansHypertension, PortalLiver CirrhosisMuscle, Smooth, VascularNitric OxideSignal TransductionSplanchnic CirculationVasodilation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18445644

Citation

Hennenberg, M, et al. "Mechanisms of Extrahepatic Vasodilation in Portal Hypertension." Gut, vol. 57, no. 9, 2008, pp. 1300-14.
Hennenberg M, Trebicka J, Sauerbruch T, et al. Mechanisms of extrahepatic vasodilation in portal hypertension. Gut. 2008;57(9):1300-14.
Hennenberg, M., Trebicka, J., Sauerbruch, T., & Heller, J. (2008). Mechanisms of extrahepatic vasodilation in portal hypertension. Gut, 57(9), 1300-14. https://doi.org/10.1136/gut.2007.144584
Hennenberg M, et al. Mechanisms of Extrahepatic Vasodilation in Portal Hypertension. Gut. 2008;57(9):1300-14. PubMed PMID: 18445644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms of extrahepatic vasodilation in portal hypertension. AU - Hennenberg,M, AU - Trebicka,J, AU - Sauerbruch,T, AU - Heller,J, Y1 - 2008/04/29/ PY - 2008/5/1/pubmed PY - 2008/9/5/medline PY - 2008/5/1/entrez SP - 1300 EP - 14 JF - Gut JO - Gut VL - 57 IS - 9 N2 - In liver cirrhosis, abnormal persistent extrahepatic vasodilation leads to hyperdynamic circulatory dysfunction which essentially contributes to portal hypertension. Since portal hypertension is a major factor in the development of complications in cirrhosis, the mechanisms underlying this vasodilation are of paramount interest. Extensive studies performed in cirrhotic patients and animals revealed that this vasodilation is associated on the one hand with enhanced formation of vasodilators, and on the other hand with vascular hyporesponsiveness to vasoconstrictors. The latter phenomenon has been termed "vascular hypocontractility". It is caused by a combination of different mechanisms and factors described in this review. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/18445644/Mechanisms_of_extrahepatic_vasodilation_in_portal_hypertension_ DB - PRIME DP - Unbound Medicine ER -