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Preparation of spherical crystal agglomerates of naproxen containing disintegrant for direct tablet making by spherical crystallization technique.
AAPS PharmSciTech. 2008; 9(1):54-9.AP

Abstract

The purpose of this research was to obtain directly compressible agglomerates of naproxen containing disintegrant by spherical crystallization technique. Acetone-water containing hydroxypropyl celloluse (HPC) and disintegrant was used as the crystallization system. In this study croscarmellose sodium (Ac-Di-Sol) was employed as disintegrant. The agglomerates were characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (XRPD), and scanning electron microscopy and were evaluated for flow, packing and tableting properties and drug release. The growth of particle size and the spherical form of the agglomerates resulted in formation of products with good flow and packing properties. The improved compaction properties of the agglomerated crystals were due to their fragmentation occurred during compression. DSC and XRPD studies showed that naproxen particles, crystallized in the presence of HPC and Ac-Di-Sol did not undergo structural modifications. The dissolution rate of naproxen from tablets made of naproxen-(Ac-Di-Sol) agglomerates was enhanced significantly because of including the disintegrant in to the particles. This was attributed to an increase in the surface area of the practically water insoluble drug is exposed to the dissolution medium. In conclusion the spherical crystallization technique developed in this study is suitable for obtaining agglomerates of drug with disintegrant.

Authors+Show Affiliations

School of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran.No affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

18446461

Citation

Nokhodchi, A, and M Maghsoodi. "Preparation of Spherical Crystal Agglomerates of Naproxen Containing Disintegrant for Direct Tablet Making By Spherical Crystallization Technique." AAPS PharmSciTech, vol. 9, no. 1, 2008, pp. 54-9.
Nokhodchi A, Maghsoodi M. Preparation of spherical crystal agglomerates of naproxen containing disintegrant for direct tablet making by spherical crystallization technique. AAPS PharmSciTech. 2008;9(1):54-9.
Nokhodchi, A., & Maghsoodi, M. (2008). Preparation of spherical crystal agglomerates of naproxen containing disintegrant for direct tablet making by spherical crystallization technique. AAPS PharmSciTech, 9(1), 54-9. https://doi.org/10.1208/s12249-007-9019-3
Nokhodchi A, Maghsoodi M. Preparation of Spherical Crystal Agglomerates of Naproxen Containing Disintegrant for Direct Tablet Making By Spherical Crystallization Technique. AAPS PharmSciTech. 2008;9(1):54-9. PubMed PMID: 18446461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation of spherical crystal agglomerates of naproxen containing disintegrant for direct tablet making by spherical crystallization technique. AU - Nokhodchi,A, AU - Maghsoodi,M, Y1 - 2008/01/09/ PY - 2007/03/06/received PY - 2007/09/25/accepted PY - 2008/5/1/pubmed PY - 2008/6/11/medline PY - 2008/5/1/entrez SP - 54 EP - 9 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 9 IS - 1 N2 - The purpose of this research was to obtain directly compressible agglomerates of naproxen containing disintegrant by spherical crystallization technique. Acetone-water containing hydroxypropyl celloluse (HPC) and disintegrant was used as the crystallization system. In this study croscarmellose sodium (Ac-Di-Sol) was employed as disintegrant. The agglomerates were characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (XRPD), and scanning electron microscopy and were evaluated for flow, packing and tableting properties and drug release. The growth of particle size and the spherical form of the agglomerates resulted in formation of products with good flow and packing properties. The improved compaction properties of the agglomerated crystals were due to their fragmentation occurred during compression. DSC and XRPD studies showed that naproxen particles, crystallized in the presence of HPC and Ac-Di-Sol did not undergo structural modifications. The dissolution rate of naproxen from tablets made of naproxen-(Ac-Di-Sol) agglomerates was enhanced significantly because of including the disintegrant in to the particles. This was attributed to an increase in the surface area of the practically water insoluble drug is exposed to the dissolution medium. In conclusion the spherical crystallization technique developed in this study is suitable for obtaining agglomerates of drug with disintegrant. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/18446461/Preparation_of_spherical_crystal_agglomerates_of_naproxen_containing_disintegrant_for_direct_tablet_making_by_spherical_crystallization_technique_ L2 - https://dx.doi.org/10.1208/s12249-007-9019-3 DB - PRIME DP - Unbound Medicine ER -