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Predictors of outcome in first-episode schizophrenia over the first 4 years of illness.
Psychol Med. 2008 Aug; 38(8):1141-6.PM

Abstract

BACKGROUND

The outcome of schizophrenia appears to be more favourable than once thought. However, methodological issues, including the reliance on diagnosis at first presentation have limited the validity of outcome studies to date.

METHOD

We conducted a first-episode follow-up study of 97 patients with DSM-IV schizophrenia over the first 4 years of illness. First presentation and follow-up assessments were compared using paired t tests and a forced-entry regression analysis was used to determine prognostic variables.

RESULTS

There were significant improvements in positive and negative symptoms and global assessment of functioning between first presentation and follow-up. At first presentation, fewer negative symptoms (t=-3.40, p<0.01), more years spent in education (t=3.25, p<0.01), and a shorter duration of untreated psychosis (DUP) (t=-2.77, p<0.01) significantly predicted a better outcome at follow-up.

CONCLUSIONS

The outcome of schizophrenia may not be as pessimistic as once thought and most patients did not display a downward deteriorating course of illness. This study supports the relationship between DUP and outcome beyond the early stages of illness.

Authors+Show Affiliations

Adelaide and Meath Hospital, Tallaght, Dublin, Ireland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18447960

Citation

Whitty, P, et al. "Predictors of Outcome in First-episode Schizophrenia Over the First 4 Years of Illness." Psychological Medicine, vol. 38, no. 8, 2008, pp. 1141-6.
Whitty P, Clarke M, McTigue O, et al. Predictors of outcome in first-episode schizophrenia over the first 4 years of illness. Psychol Med. 2008;38(8):1141-6.
Whitty, P., Clarke, M., McTigue, O., Browne, S., Kamali, M., Kinsella, A., Larkin, C., & O'Callaghan, E. (2008). Predictors of outcome in first-episode schizophrenia over the first 4 years of illness. Psychological Medicine, 38(8), 1141-6. https://doi.org/10.1017/S003329170800336X
Whitty P, et al. Predictors of Outcome in First-episode Schizophrenia Over the First 4 Years of Illness. Psychol Med. 2008;38(8):1141-6. PubMed PMID: 18447960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictors of outcome in first-episode schizophrenia over the first 4 years of illness. AU - Whitty,P, AU - Clarke,M, AU - McTigue,O, AU - Browne,S, AU - Kamali,M, AU - Kinsella,A, AU - Larkin,C, AU - O'Callaghan,E, Y1 - 2008/04/30/ PY - 2008/5/2/pubmed PY - 2008/11/19/medline PY - 2008/5/2/entrez SP - 1141 EP - 6 JF - Psychological medicine JO - Psychol Med VL - 38 IS - 8 N2 - BACKGROUND: The outcome of schizophrenia appears to be more favourable than once thought. However, methodological issues, including the reliance on diagnosis at first presentation have limited the validity of outcome studies to date. METHOD: We conducted a first-episode follow-up study of 97 patients with DSM-IV schizophrenia over the first 4 years of illness. First presentation and follow-up assessments were compared using paired t tests and a forced-entry regression analysis was used to determine prognostic variables. RESULTS: There were significant improvements in positive and negative symptoms and global assessment of functioning between first presentation and follow-up. At first presentation, fewer negative symptoms (t=-3.40, p<0.01), more years spent in education (t=3.25, p<0.01), and a shorter duration of untreated psychosis (DUP) (t=-2.77, p<0.01) significantly predicted a better outcome at follow-up. CONCLUSIONS: The outcome of schizophrenia may not be as pessimistic as once thought and most patients did not display a downward deteriorating course of illness. This study supports the relationship between DUP and outcome beyond the early stages of illness. SN - 0033-2917 UR - https://www.unboundmedicine.com/medline/citation/18447960/Predictors_of_outcome_in_first_episode_schizophrenia_over_the_first_4_years_of_illness_ L2 - https://www.cambridge.org/core/product/identifier/S003329170800336X/type/journal_article DB - PRIME DP - Unbound Medicine ER -