Tags

Type your tag names separated by a space and hit enter

HPA-axis activity and externalizing behavior problems in early adolescents from the general population: the role of comorbidity and gender The TRAILS study.
Psychoneuroendocrinology. 2008 Jul; 33(6):789-98.P

Abstract

Contradictory findings on the relationship between hypothalamus-pituitary-adrenal (HPA)-axis activity and externalizing behavior problems could be due to studies not accounting for issues of comorbidity and gender. In a population-based cohort of 1768 (10- to 12-year-old) early adolescents, we used a person-oriented approach and a variable-oriented approach to investigate whether comorbidity with internalizing behavior problems and gender moderate the relationship between HPA-axis activity (cortisol awakening response and evening cortisol levels) and externalizing behavior problems. We found that: (1) in early adolescents with pure externalizing behavior problems, there was a particularly strong effect of gender, in that girls showed significantly higher total cortisol levels after awakening (AUC(G) levels) and a significantly higher cortisol awakening response (AUC(I) levels) than boys. (2) Girls with pure externalizing behavior problems showed a significantly higher cortisol awakening response (AUC(I) levels) than girls without behavior problems or girls with comorbid internalizing behavior problems. This effect was absent in boys. (3) Externalizing behavior problems, in contrast to internalizing behavior problems, were associated with higher evening cortisol levels. This effect might, however, result from girls with externalizing behavior problems showing the highest evening cortisol levels. Overall, we were unable to find the expected relationships between comorbidity and HPA-axis activity, and found girls with pure externalizing behavior problems to form a distinct group with regard to their HPA-axis activity. There is need for prospective longitudinal studies of externalizing behavior problems in boys and girls in relation to their HPA-axis activity. It would be useful to consider how other risk factors such as life events and family and parenting factors as well as genetic risks affect the complex relationship between externalizing behavior problems and HPA-axis activity.

Authors+Show Affiliations

Department of Psychiatry, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. R.Marsman@psy.umcn.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18448258

Citation

Marsman, Rianne, et al. "HPA-axis Activity and Externalizing Behavior Problems in Early Adolescents From the General Population: the Role of Comorbidity and Gender the TRAILS Study." Psychoneuroendocrinology, vol. 33, no. 6, 2008, pp. 789-98.
Marsman R, Swinkels SH, Rosmalen JG, et al. HPA-axis activity and externalizing behavior problems in early adolescents from the general population: the role of comorbidity and gender The TRAILS study. Psychoneuroendocrinology. 2008;33(6):789-98.
Marsman, R., Swinkels, S. H., Rosmalen, J. G., Oldehinkel, A. J., Ormel, J., & Buitelaar, J. K. (2008). HPA-axis activity and externalizing behavior problems in early adolescents from the general population: the role of comorbidity and gender The TRAILS study. Psychoneuroendocrinology, 33(6), 789-98. https://doi.org/10.1016/j.psyneuen.2008.03.005
Marsman R, et al. HPA-axis Activity and Externalizing Behavior Problems in Early Adolescents From the General Population: the Role of Comorbidity and Gender the TRAILS Study. Psychoneuroendocrinology. 2008;33(6):789-98. PubMed PMID: 18448258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HPA-axis activity and externalizing behavior problems in early adolescents from the general population: the role of comorbidity and gender The TRAILS study. AU - Marsman,Rianne, AU - Swinkels,Sophie H N, AU - Rosmalen,Judith G M, AU - Oldehinkel,Albertine J, AU - Ormel,Johan, AU - Buitelaar,Jan K, Y1 - 2008/04/29/ PY - 2007/10/12/received PY - 2008/03/10/revised PY - 2008/03/12/accepted PY - 2008/5/2/pubmed PY - 2008/10/9/medline PY - 2008/5/2/entrez SP - 789 EP - 98 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 33 IS - 6 N2 - Contradictory findings on the relationship between hypothalamus-pituitary-adrenal (HPA)-axis activity and externalizing behavior problems could be due to studies not accounting for issues of comorbidity and gender. In a population-based cohort of 1768 (10- to 12-year-old) early adolescents, we used a person-oriented approach and a variable-oriented approach to investigate whether comorbidity with internalizing behavior problems and gender moderate the relationship between HPA-axis activity (cortisol awakening response and evening cortisol levels) and externalizing behavior problems. We found that: (1) in early adolescents with pure externalizing behavior problems, there was a particularly strong effect of gender, in that girls showed significantly higher total cortisol levels after awakening (AUC(G) levels) and a significantly higher cortisol awakening response (AUC(I) levels) than boys. (2) Girls with pure externalizing behavior problems showed a significantly higher cortisol awakening response (AUC(I) levels) than girls without behavior problems or girls with comorbid internalizing behavior problems. This effect was absent in boys. (3) Externalizing behavior problems, in contrast to internalizing behavior problems, were associated with higher evening cortisol levels. This effect might, however, result from girls with externalizing behavior problems showing the highest evening cortisol levels. Overall, we were unable to find the expected relationships between comorbidity and HPA-axis activity, and found girls with pure externalizing behavior problems to form a distinct group with regard to their HPA-axis activity. There is need for prospective longitudinal studies of externalizing behavior problems in boys and girls in relation to their HPA-axis activity. It would be useful to consider how other risk factors such as life events and family and parenting factors as well as genetic risks affect the complex relationship between externalizing behavior problems and HPA-axis activity. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/18448258/HPA_axis_activity_and_externalizing_behavior_problems_in_early_adolescents_from_the_general_population:_the_role_of_comorbidity_and_gender_The_TRAILS_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(08)00068-1 DB - PRIME DP - Unbound Medicine ER -