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Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents.

Abstract

OBJECTIVE

The aim of the study was to assess omega 3/6 fatty acids (eye q) in attention deficit hyperactivity disorder (ADHD).

METHOD

The study included a randomized, 3-month, omega 3/6 placebo-controlled, one-way crossover trial with 75 children and adolescents (8-18 years), followed by 3 months with omega 3/6 for all. Investigator-rated ADHD Rating Scale-IV and Clinical Global Impression (CGI) scale were outcome measures.

RESULTS

A majority did not respond to omega 3/6 treatment. However, a subgroup of 26% responded with more than 25% reduction of ADHD symptoms and a drop of CGI scores to the near-normal range. After 6 months, 47% of all showed such improvement. Responders tended to have ADHD inattentive subtype and comorbid neurodevelopmental disorders.

CONCLUSION

A subgroup of children and adolescents with ADHD, characterized by inattention and associated neurodevelopmental disorders, treated with omega 3/6 fatty acids for 6 months responded with meaningful reduction of ADHD symptoms.

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  • Authors+Show Affiliations

    ,

    Department of Child and Adolescent Psychiatry, Göteborg University, Göteborg, Sweden. mats.k.johnson@vgregion.se

    , , ,

    Source

    Journal of attention disorders 12:5 2009 Mar pg 394-401

    MeSH

    Adolescent
    Attention Deficit Disorder with Hyperactivity
    Autistic Disorder
    Child
    Comorbidity
    Cross-Over Studies
    Double-Blind Method
    Dyslexia
    Fatty Acids, Omega-3
    Fatty Acids, Omega-6
    Follow-Up Studies
    Humans
    Learning Disorders
    Motor Skills Disorders
    Personality Assessment
    Writing

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18448859

    Citation

    Johnson, Mats, et al. "Omega-3/omega-6 Fatty Acids for Attention Deficit Hyperactivity Disorder: a Randomized Placebo-controlled Trial in Children and Adolescents." Journal of Attention Disorders, vol. 12, no. 5, 2009, pp. 394-401.
    Johnson M, Ostlund S, Fransson G, et al. Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents. J Atten Disord. 2009;12(5):394-401.
    Johnson, M., Ostlund, S., Fransson, G., Kadesjö, B., & Gillberg, C. (2009). Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents. Journal of Attention Disorders, 12(5), pp. 394-401. doi:10.1177/1087054708316261.
    Johnson M, et al. Omega-3/omega-6 Fatty Acids for Attention Deficit Hyperactivity Disorder: a Randomized Placebo-controlled Trial in Children and Adolescents. J Atten Disord. 2009;12(5):394-401. PubMed PMID: 18448859.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents. AU - Johnson,Mats, AU - Ostlund,Sven, AU - Fransson,Gunnar, AU - Kadesjö,Björn, AU - Gillberg,Christopher, Y1 - 2008/04/30/ PY - 2008/5/2/pubmed PY - 2009/5/12/medline PY - 2008/5/2/entrez SP - 394 EP - 401 JF - Journal of attention disorders JO - J Atten Disord VL - 12 IS - 5 N2 - OBJECTIVE: The aim of the study was to assess omega 3/6 fatty acids (eye q) in attention deficit hyperactivity disorder (ADHD). METHOD: The study included a randomized, 3-month, omega 3/6 placebo-controlled, one-way crossover trial with 75 children and adolescents (8-18 years), followed by 3 months with omega 3/6 for all. Investigator-rated ADHD Rating Scale-IV and Clinical Global Impression (CGI) scale were outcome measures. RESULTS: A majority did not respond to omega 3/6 treatment. However, a subgroup of 26% responded with more than 25% reduction of ADHD symptoms and a drop of CGI scores to the near-normal range. After 6 months, 47% of all showed such improvement. Responders tended to have ADHD inattentive subtype and comorbid neurodevelopmental disorders. CONCLUSION: A subgroup of children and adolescents with ADHD, characterized by inattention and associated neurodevelopmental disorders, treated with omega 3/6 fatty acids for 6 months responded with meaningful reduction of ADHD symptoms. SN - 1087-0547 UR - https://www.unboundmedicine.com/medline/citation/18448859/Omega_3/omega_6_fatty_acids_for_attention_deficit_hyperactivity_disorder:_a_randomized_placebo_controlled_trial_in_children_and_adolescents_ L2 - http://journals.sagepub.com/doi/full/10.1177/1087054708316261?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -