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VBM anticipates the rate of progression of Alzheimer disease: a 3-year longitudinal study.
Neurology. 2008 Jun 03; 70(23):2201-11.Neur

Abstract

OBJECTIVE

To determine whether regional atrophy or neuropsychological factors can predict the rate of decline in patients with mild Alzheimer disease (AD).

BACKGROUND

Despite important implications for planning the care and treatment strategy, few prognostic factors of severe AD progression are known.

METHODS

Twenty-three patients with mild AD were followed up every 6 months over the course of 3 years. At baseline, patients with AD and 18 controls underwent a neuropsychological battery and a brain MRI. At the end of the 3 years, patients with AD were dichotomized into slow decliners (SLD) or fast decliners (FD) groups on the basis of their decline in Mini-Mental State Examination score over time. We compared baseline cognitive performance and imaging data using voxel-based morphometry (VBM).

RESULTS

SLD and FD groups did not differ in age, gender, level of education, mean estimated duration of illness, and standard neuropsychological data at inclusion, except for the Attentional Battery of the Cambridge Neuropsychological Tests Automated Battery (speed processing in shifting condition). VBM comparison between SLD and FD groups demonstrated more gray matter tissue loss in the FD group in the medial occipitoparietal areas, especially in the precuneus, the lingual gyrus, the cuneus, and the surrounding cortex of the parieto-occipital sulcus bilaterally.

CONCLUSION

Voxel-based morphometry analysis demonstrated that patients who will have a faster decline at 3 years already had a more extensive cortical atrophy than SLD patients, especially in the medial occipitoparietal areas, which was not yet detected by clinical and neuropsychological assessment.

Authors+Show Affiliations

INSERM U610, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18448872

Citation

Kinkingnéhun, S, et al. "VBM Anticipates the Rate of Progression of Alzheimer Disease: a 3-year Longitudinal Study." Neurology, vol. 70, no. 23, 2008, pp. 2201-11.
Kinkingnéhun S, Sarazin M, Lehéricy S, et al. VBM anticipates the rate of progression of Alzheimer disease: a 3-year longitudinal study. Neurology. 2008;70(23):2201-11.
Kinkingnéhun, S., Sarazin, M., Lehéricy, S., Guichart-Gomez, E., Hergueta, T., & Dubois, B. (2008). VBM anticipates the rate of progression of Alzheimer disease: a 3-year longitudinal study. Neurology, 70(23), 2201-11. https://doi.org/10.1212/01.wnl.0000303960.01039.43
Kinkingnéhun S, et al. VBM Anticipates the Rate of Progression of Alzheimer Disease: a 3-year Longitudinal Study. Neurology. 2008 Jun 3;70(23):2201-11. PubMed PMID: 18448872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - VBM anticipates the rate of progression of Alzheimer disease: a 3-year longitudinal study. AU - Kinkingnéhun,S, AU - Sarazin,M, AU - Lehéricy,S, AU - Guichart-Gomez,E, AU - Hergueta,T, AU - Dubois,B, Y1 - 2008/04/30/ PY - 2008/5/2/pubmed PY - 2008/6/17/medline PY - 2008/5/2/entrez SP - 2201 EP - 11 JF - Neurology JO - Neurology VL - 70 IS - 23 N2 - OBJECTIVE: To determine whether regional atrophy or neuropsychological factors can predict the rate of decline in patients with mild Alzheimer disease (AD). BACKGROUND: Despite important implications for planning the care and treatment strategy, few prognostic factors of severe AD progression are known. METHODS: Twenty-three patients with mild AD were followed up every 6 months over the course of 3 years. At baseline, patients with AD and 18 controls underwent a neuropsychological battery and a brain MRI. At the end of the 3 years, patients with AD were dichotomized into slow decliners (SLD) or fast decliners (FD) groups on the basis of their decline in Mini-Mental State Examination score over time. We compared baseline cognitive performance and imaging data using voxel-based morphometry (VBM). RESULTS: SLD and FD groups did not differ in age, gender, level of education, mean estimated duration of illness, and standard neuropsychological data at inclusion, except for the Attentional Battery of the Cambridge Neuropsychological Tests Automated Battery (speed processing in shifting condition). VBM comparison between SLD and FD groups demonstrated more gray matter tissue loss in the FD group in the medial occipitoparietal areas, especially in the precuneus, the lingual gyrus, the cuneus, and the surrounding cortex of the parieto-occipital sulcus bilaterally. CONCLUSION: Voxel-based morphometry analysis demonstrated that patients who will have a faster decline at 3 years already had a more extensive cortical atrophy than SLD patients, especially in the medial occipitoparietal areas, which was not yet detected by clinical and neuropsychological assessment. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/18448872/VBM_anticipates_the_rate_of_progression_of_Alzheimer_disease:_a_3_year_longitudinal_study_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=18448872 DB - PRIME DP - Unbound Medicine ER -