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Hyperphosphatemia of chronic kidney disease.
Kidney Int. 2008 Jul; 74(2):148-57.KI

Abstract

Observational studies have determined hyperphosphatemia to be a cardiovascular risk factor in chronic kidney disease. Mechanistic studies have elucidated that hyperphosphatemia is a direct stimulus to vascular calcification, which is one cause of morbid cardiovascular events contributing to the excess mortality of chronic kidney disease. This review describes the pathobiology of hyperphosphatemia that develops as a consequence of positive phosphate balance in chronic kidney disease and the mechanisms by which hyperphosphatemia acts on neointimal vascular cells that are stimulated to mineralize in chronic kidney disease. The characterization of hyperphosphatemia of chronic kidney disease as a distinct syndrome in clinical medicine with unique disordered skeletal remodeling, heterotopic mineralization and cardiovascular morbidity is presented.

Authors+Show Affiliations

Department of Pediatrics, Renal Division, Washington University, St Louis, Missouri 63110, USA. Hruska_k@kids.wustl.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18449174

Citation

Hruska, Keith A., et al. "Hyperphosphatemia of Chronic Kidney Disease." Kidney International, vol. 74, no. 2, 2008, pp. 148-57.
Hruska KA, Mathew S, Lund R, et al. Hyperphosphatemia of chronic kidney disease. Kidney Int. 2008;74(2):148-57.
Hruska, K. A., Mathew, S., Lund, R., Qiu, P., & Pratt, R. (2008). Hyperphosphatemia of chronic kidney disease. Kidney International, 74(2), 148-57. https://doi.org/10.1038/ki.2008.130
Hruska KA, et al. Hyperphosphatemia of Chronic Kidney Disease. Kidney Int. 2008;74(2):148-57. PubMed PMID: 18449174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperphosphatemia of chronic kidney disease. AU - Hruska,Keith A, AU - Mathew,Suresh, AU - Lund,Richard, AU - Qiu,Ping, AU - Pratt,Raymond, Y1 - 2008/04/30/ PY - 2008/5/2/pubmed PY - 2008/8/5/medline PY - 2008/5/2/entrez SP - 148 EP - 57 JF - Kidney international JO - Kidney Int VL - 74 IS - 2 N2 - Observational studies have determined hyperphosphatemia to be a cardiovascular risk factor in chronic kidney disease. Mechanistic studies have elucidated that hyperphosphatemia is a direct stimulus to vascular calcification, which is one cause of morbid cardiovascular events contributing to the excess mortality of chronic kidney disease. This review describes the pathobiology of hyperphosphatemia that develops as a consequence of positive phosphate balance in chronic kidney disease and the mechanisms by which hyperphosphatemia acts on neointimal vascular cells that are stimulated to mineralize in chronic kidney disease. The characterization of hyperphosphatemia of chronic kidney disease as a distinct syndrome in clinical medicine with unique disordered skeletal remodeling, heterotopic mineralization and cardiovascular morbidity is presented. SN - 1523-1755 UR - https://www.unboundmedicine.com/medline/citation/18449174/Hyperphosphatemia_of_chronic_kidney_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0085-2538(15)53280-8 DB - PRIME DP - Unbound Medicine ER -