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Heat stability of chaetoglobosins A and C.
Can J Microbiol. 2008 May; 54(5):423-5.CJ

Abstract

Chaetomium globosum is commonly found in water-damaged buildings and produces the mycotoxins chaetoglobosin A and chaetoglobosin C (Ch-A and Ch-C, respectively). While attempting to purify Ch-A and Ch-C, we observed that these mycotoxins were broken down after heating. The objective of this study was to determine the temperature and the amount of time necessary to break down Ch-A and Ch-C. We demonstrated that the amounts of Ch-A were significantly reduced when exposed to 75 degrees C for 24 h and 100 degrees C for 90, 120, or 150 min. Under the same conditions, the levels of Ch-C were also lower (although not significantly). At 175 degrees C, no Ch-A was detected after 15 min and Ch-C was significantly reduced after 30 min. Our findings will aid other researchers who work with these mycotoxins in the future.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Fogle MR
Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Douglas DR
No affiliation info available
Jumper CA
No affiliation info available
Straus DC
No affiliation info available

MeSH

ChaetomiumHot TemperatureIndole AlkaloidsTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18449228

Citation

Fogle, M R., et al. "Heat Stability of Chaetoglobosins a and C." Canadian Journal of Microbiology, vol. 54, no. 5, 2008, pp. 423-5.
Fogle MR, Douglas DR, Jumper CA, et al. Heat stability of chaetoglobosins A and C. Can J Microbiol. 2008;54(5):423-5.
Fogle, M. R., Douglas, D. R., Jumper, C. A., & Straus, D. C. (2008). Heat stability of chaetoglobosins A and C. Canadian Journal of Microbiology, 54(5), 423-5. https://doi.org/10.1139/w08-024
Fogle MR, et al. Heat Stability of Chaetoglobosins a and C. Can J Microbiol. 2008;54(5):423-5. PubMed PMID: 18449228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heat stability of chaetoglobosins A and C. AU - Fogle,M R, AU - Douglas,D R, AU - Jumper,C A, AU - Straus,D C, PY - 2008/5/2/pubmed PY - 2008/7/23/medline PY - 2008/5/2/entrez SP - 423 EP - 5 JF - Canadian journal of microbiology JO - Can J Microbiol VL - 54 IS - 5 N2 - Chaetomium globosum is commonly found in water-damaged buildings and produces the mycotoxins chaetoglobosin A and chaetoglobosin C (Ch-A and Ch-C, respectively). While attempting to purify Ch-A and Ch-C, we observed that these mycotoxins were broken down after heating. The objective of this study was to determine the temperature and the amount of time necessary to break down Ch-A and Ch-C. We demonstrated that the amounts of Ch-A were significantly reduced when exposed to 75 degrees C for 24 h and 100 degrees C for 90, 120, or 150 min. Under the same conditions, the levels of Ch-C were also lower (although not significantly). At 175 degrees C, no Ch-A was detected after 15 min and Ch-C was significantly reduced after 30 min. Our findings will aid other researchers who work with these mycotoxins in the future. SN - 0008-4166 UR - https://www.unboundmedicine.com/medline/citation/18449228/Heat_stability_of_chaetoglobosins_A_and_C_ DB - PRIME DP - Unbound Medicine ER -