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The medical management of primary sclerosing cholangitis.
Medscape J Med 2008; 10(3):61MJ

Abstract

Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease of uncertain etiology characterized by the destruction of the intrahepatic and/or extrahepatic ducts through inflammation and fibrosis. This ultimately leads to biliary complications including cirrhosis, cholangiocarcinoma, and eventually death. Given the uncertainty surrounding the pathogenesis of the disease, a number of different medical therapies have been studied in the treatment of PSC. However, there currently are no effective medical therapies known to halt the progression of disease. The only definitive therapy for PSC is liver transplantation. This review will primarily focus on the medical approaches that have been studied for the treatment of PSC as well as on the management of symptoms commonly associated with the disease.

Authors+Show Affiliations

Division of Gastroenterology, Hepatology, and Nutrition, University of Florida-Gainesville, USA. Anthony.michaels@medicine.ufl.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18449341

Citation

Michaels, Anthony, and Cynthia Levy. "The Medical Management of Primary Sclerosing Cholangitis." Medscape Journal of Medicine, vol. 10, no. 3, 2008, p. 61.
Michaels A, Levy C. The medical management of primary sclerosing cholangitis. Medscape J Med. 2008;10(3):61.
Michaels, A., & Levy, C. (2008). The medical management of primary sclerosing cholangitis. Medscape Journal of Medicine, 10(3), p. 61.
Michaels A, Levy C. The Medical Management of Primary Sclerosing Cholangitis. Medscape J Med. 2008 Mar 12;10(3):61. PubMed PMID: 18449341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The medical management of primary sclerosing cholangitis. AU - Michaels,Anthony, AU - Levy,Cynthia, Y1 - 2008/03/12/ PY - 2008/5/2/pubmed PY - 2008/6/5/medline PY - 2008/5/2/entrez SP - 61 EP - 61 JF - Medscape journal of medicine JO - Medscape J Med VL - 10 IS - 3 N2 - Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease of uncertain etiology characterized by the destruction of the intrahepatic and/or extrahepatic ducts through inflammation and fibrosis. This ultimately leads to biliary complications including cirrhosis, cholangiocarcinoma, and eventually death. Given the uncertainty surrounding the pathogenesis of the disease, a number of different medical therapies have been studied in the treatment of PSC. However, there currently are no effective medical therapies known to halt the progression of disease. The only definitive therapy for PSC is liver transplantation. This review will primarily focus on the medical approaches that have been studied for the treatment of PSC as well as on the management of symptoms commonly associated with the disease. SN - 1934-1997 UR - https://www.unboundmedicine.com/medline/citation/18449341/The_medical_management_of_primary_sclerosing_cholangitis_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18449341/ DB - PRIME DP - Unbound Medicine ER -