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Neural correlates of verbal episodic memory in patients with MCI and Alzheimer's disease--a VBM study.
Int J Geriatr Psychiatry. 2008 Nov; 23(11):1114-8.IJ

Abstract

OBJECTIVE

The hippocampus is a key area for episodic memory processes. Hippocampal atrophy is a hallmark feature of Alzheimer's disease (AD). We used a new and automatized morphometric technique to better characterize brain atrophy in subjects with different levels of cognitive deficit.

METHODS

In this study 21 participants with Mild Cognitive Impairment (MCI), 12 patients with early AD and 29 elderly control subjects were subjected to high resolution MRI and a neuropsychological test battery. Brain volume across participants, measured by voxel-based morphometry (VBM), was correlated with verbal memory capacity, measured with a verbal memory test (VLMT).

RESULTS

Atrophy in the anterior hippocampus, the ento- and perirhinal cortex as well as the parahippocampal gyrus, middle temporal gyrus and anterior cingulate cortex correlated closely with episodic memory performance.

CONCLUSIONS

These brain areas are known to subserve episodic encoding of verbal material. The data contribute to a better understanding of atrophic brain processes in subjects at risk for AD. A combination of neuropsychological testing and voxel-based morphometry may serve as a diagnostic tool in the future.

Authors+Show Affiliations

Department of Psychiatry, University Hospital Aachen, Pauwelsstrasse 30, Aachen, Germany. dleube@ukaachen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18449954

Citation

Leube, Dirk T., et al. "Neural Correlates of Verbal Episodic Memory in Patients With MCI and Alzheimer's Disease--a VBM Study." International Journal of Geriatric Psychiatry, vol. 23, no. 11, 2008, pp. 1114-8.
Leube DT, Weis S, Freymann K, et al. Neural correlates of verbal episodic memory in patients with MCI and Alzheimer's disease--a VBM study. Int J Geriatr Psychiatry. 2008;23(11):1114-8.
Leube, D. T., Weis, S., Freymann, K., Erb, M., Jessen, F., Heun, R., Grodd, W., & Kircher, T. T. (2008). Neural correlates of verbal episodic memory in patients with MCI and Alzheimer's disease--a VBM study. International Journal of Geriatric Psychiatry, 23(11), 1114-8. https://doi.org/10.1002/gps.2036
Leube DT, et al. Neural Correlates of Verbal Episodic Memory in Patients With MCI and Alzheimer's Disease--a VBM Study. Int J Geriatr Psychiatry. 2008;23(11):1114-8. PubMed PMID: 18449954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neural correlates of verbal episodic memory in patients with MCI and Alzheimer's disease--a VBM study. AU - Leube,Dirk T, AU - Weis,Susanne, AU - Freymann,Kathrin, AU - Erb,Michael, AU - Jessen,Frank, AU - Heun,Reinhard, AU - Grodd,Wolfgang, AU - Kircher,Tilo T, PY - 2008/5/2/pubmed PY - 2009/5/22/medline PY - 2008/5/2/entrez SP - 1114 EP - 8 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 23 IS - 11 N2 - OBJECTIVE: The hippocampus is a key area for episodic memory processes. Hippocampal atrophy is a hallmark feature of Alzheimer's disease (AD). We used a new and automatized morphometric technique to better characterize brain atrophy in subjects with different levels of cognitive deficit. METHODS: In this study 21 participants with Mild Cognitive Impairment (MCI), 12 patients with early AD and 29 elderly control subjects were subjected to high resolution MRI and a neuropsychological test battery. Brain volume across participants, measured by voxel-based morphometry (VBM), was correlated with verbal memory capacity, measured with a verbal memory test (VLMT). RESULTS: Atrophy in the anterior hippocampus, the ento- and perirhinal cortex as well as the parahippocampal gyrus, middle temporal gyrus and anterior cingulate cortex correlated closely with episodic memory performance. CONCLUSIONS: These brain areas are known to subserve episodic encoding of verbal material. The data contribute to a better understanding of atrophic brain processes in subjects at risk for AD. A combination of neuropsychological testing and voxel-based morphometry may serve as a diagnostic tool in the future. SN - 1099-1166 UR - https://www.unboundmedicine.com/medline/citation/18449954/Neural_correlates_of_verbal_episodic_memory_in_patients_with_MCI_and_Alzheimer's_disease__a_VBM_study_ L2 - https://doi.org/10.1002/gps.2036 DB - PRIME DP - Unbound Medicine ER -