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Parental psychiatric disorders associated with autism spectrum disorders in the offspring.
Pediatrics. 2008 May; 121(5):e1357-62.Ped

Abstract

OBJECTIVE

Autism is a developmental disorder defined by impaired social interaction, communication, and behavior. Causes and correlates of autism are largely unknown, but elevated frequencies of psychiatric disorders and distinct personality traits have been reported among the family members of individuals with autism. Linkage of data from Swedish registries was used to investigate whether hospitalization for psychiatric conditions was higher among parents of children with autism compared with control subjects.

METHODS

Data sources included the Swedish Medical Birth Register (child's birth), the Swedish Multi-Generation Register (linking parents to children), and Swedish Hospital Discharge Register (hospitalization records). Children born between 1977 and 2003 who had a hospitalization record indicating autism before 10 years of age (n = 1227) were matched with 30,693 control subjects from the Swedish Medical Birth Register by gender, year of birth, and hospital. Parent diagnoses were based on an inpatient hospital diagnostic evaluation and included schizophrenia, other nonaffective psychoses, affective disorders, neurotic and personality disorders and other nonpsychotic disorders, alcohol and drug addiction and abuse, and autism. Odds ratios and 95% confidence intervals were estimated by using conditional logistic regression, adjusted for child's age, gender, hospital of birth, parents' age, country of birth and socioeconomic status, and diagnosis of a mental disorder in the other parent.

RESULTS

Parents of children with autism were more likely to have been hospitalized for a mental disorder than parents of control subjects. Schizophrenia was more common among case mothers and fathers compared with respective control parents. Depression and personality disorders were more common among case mothers but not fathers. CONCLUSIONS; This large population study supports the potential for familial aggregation of psychiatric conditions that may provide leads for future investigations of heritable forms of autism.

Authors+Show Affiliations

Department of Epidemiology, CB 7435, University of North Carolina, Chapel Hill, NC 27599-7435, USA. juliedaniels@unc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

18450879

Citation

Daniels, Julie L., et al. "Parental Psychiatric Disorders Associated With Autism Spectrum Disorders in the Offspring." Pediatrics, vol. 121, no. 5, 2008, pp. e1357-62.
Daniels JL, Forssen U, Hultman CM, et al. Parental psychiatric disorders associated with autism spectrum disorders in the offspring. Pediatrics. 2008;121(5):e1357-62.
Daniels, J. L., Forssen, U., Hultman, C. M., Cnattingius, S., Savitz, D. A., Feychting, M., & Sparen, P. (2008). Parental psychiatric disorders associated with autism spectrum disorders in the offspring. Pediatrics, 121(5), e1357-62. https://doi.org/10.1542/peds.2007-2296
Daniels JL, et al. Parental Psychiatric Disorders Associated With Autism Spectrum Disorders in the Offspring. Pediatrics. 2008;121(5):e1357-62. PubMed PMID: 18450879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental psychiatric disorders associated with autism spectrum disorders in the offspring. AU - Daniels,Julie L, AU - Forssen,Ulla, AU - Hultman,Christina M, AU - Cnattingius,Sven, AU - Savitz,David A, AU - Feychting,Maria, AU - Sparen,Par, PY - 2008/5/3/pubmed PY - 2008/6/5/medline PY - 2008/5/3/entrez SP - e1357 EP - 62 JF - Pediatrics JO - Pediatrics VL - 121 IS - 5 N2 - OBJECTIVE: Autism is a developmental disorder defined by impaired social interaction, communication, and behavior. Causes and correlates of autism are largely unknown, but elevated frequencies of psychiatric disorders and distinct personality traits have been reported among the family members of individuals with autism. Linkage of data from Swedish registries was used to investigate whether hospitalization for psychiatric conditions was higher among parents of children with autism compared with control subjects. METHODS: Data sources included the Swedish Medical Birth Register (child's birth), the Swedish Multi-Generation Register (linking parents to children), and Swedish Hospital Discharge Register (hospitalization records). Children born between 1977 and 2003 who had a hospitalization record indicating autism before 10 years of age (n = 1227) were matched with 30,693 control subjects from the Swedish Medical Birth Register by gender, year of birth, and hospital. Parent diagnoses were based on an inpatient hospital diagnostic evaluation and included schizophrenia, other nonaffective psychoses, affective disorders, neurotic and personality disorders and other nonpsychotic disorders, alcohol and drug addiction and abuse, and autism. Odds ratios and 95% confidence intervals were estimated by using conditional logistic regression, adjusted for child's age, gender, hospital of birth, parents' age, country of birth and socioeconomic status, and diagnosis of a mental disorder in the other parent. RESULTS: Parents of children with autism were more likely to have been hospitalized for a mental disorder than parents of control subjects. Schizophrenia was more common among case mothers and fathers compared with respective control parents. Depression and personality disorders were more common among case mothers but not fathers. CONCLUSIONS; This large population study supports the potential for familial aggregation of psychiatric conditions that may provide leads for future investigations of heritable forms of autism. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/18450879/Parental_psychiatric_disorders_associated_with_autism_spectrum_disorders_in_the_offspring_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=18450879 DB - PRIME DP - Unbound Medicine ER -