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Clinical significance of microsatellite instability in sporadic epithelial ovarian tumors.
Yonsei Med J. 2008 Apr 30; 49(2):272-8.YM

Abstract

PURPOSE

We evaluated the expression of microsatellite instability (MSI) in sporadic ovarian tumors using 5 standard and 9 new MSI markers to determine the clinical significance of MSI in sporadic epithelial ovarian tumors.

MATERIALS AND METHODS

MSI was examined in 21 borderline and 25 malignant ovarian tumors. Polymerase chain reaction (PCR) was performed using the 5 markers recommended by the National Cancer Institute (NCI) for colon cancer and 9 additional markers. MSI was determined using fractional analysis by mixing the PCR products and size markers.

RESULTS

Using the 5 conventional MSI markers, MSI was found in 4 of 46 (8.6%) ovarian tumors, including 2 of 21 (9.5%) borderline ovarian tumors and 2 of 25 (8%) malignant ovarian tumors. Using the 9 additional MSI markers, MSI was observed in 7 of 46 (15.2%) ovarian tumors, including 3 of 21 (14.3%) borderline ovarian tumors and 4 of 25 (16%) malignant ovarian tumors. There was no statistically significant difference between MSI and clinicopathological factors, including histology and stage, although there was a trend toward an increased incidence of MSI in the serous type.

CONCLUSION

MSI was infrequent in ovarian tumors, including both borderline and malignant tumors. MSI was found to be uncommon in sporadic ovarian tumors, even by using additional MSI markers. The clinical significance of MSI is not strong in patients with sporadic ovarian tumors.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, College of Medicine, Pochon CHA University, and Myongii Hospital, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18452265

Citation

Yoon, Bo-Sung, et al. "Clinical Significance of Microsatellite Instability in Sporadic Epithelial Ovarian Tumors." Yonsei Medical Journal, vol. 49, no. 2, 2008, pp. 272-8.
Yoon BS, Kim YT, Kim JH, et al. Clinical significance of microsatellite instability in sporadic epithelial ovarian tumors. Yonsei Med J. 2008;49(2):272-8.
Yoon, B. S., Kim, Y. T., Kim, J. H., Kim, S. W., Nam, E. J., Cho, N. H., Kim, J. W., & Kim, S. (2008). Clinical significance of microsatellite instability in sporadic epithelial ovarian tumors. Yonsei Medical Journal, 49(2), 272-8. https://doi.org/10.3349/ymj.2008.49.2.272
Yoon BS, et al. Clinical Significance of Microsatellite Instability in Sporadic Epithelial Ovarian Tumors. Yonsei Med J. 2008 Apr 30;49(2):272-8. PubMed PMID: 18452265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical significance of microsatellite instability in sporadic epithelial ovarian tumors. AU - Yoon,Bo-Sung, AU - Kim,Young-Tae, AU - Kim,Jae-Hoon, AU - Kim,Sang-Wun, AU - Nam,Eun-Ji, AU - Cho,Nam-Hoon, AU - Kim,Jae-Wook, AU - Kim,Sunghoon, PY - 2008/5/3/pubmed PY - 2008/7/17/medline PY - 2008/5/3/entrez SP - 272 EP - 8 JF - Yonsei medical journal JO - Yonsei Med J VL - 49 IS - 2 N2 - PURPOSE: We evaluated the expression of microsatellite instability (MSI) in sporadic ovarian tumors using 5 standard and 9 new MSI markers to determine the clinical significance of MSI in sporadic epithelial ovarian tumors. MATERIALS AND METHODS: MSI was examined in 21 borderline and 25 malignant ovarian tumors. Polymerase chain reaction (PCR) was performed using the 5 markers recommended by the National Cancer Institute (NCI) for colon cancer and 9 additional markers. MSI was determined using fractional analysis by mixing the PCR products and size markers. RESULTS: Using the 5 conventional MSI markers, MSI was found in 4 of 46 (8.6%) ovarian tumors, including 2 of 21 (9.5%) borderline ovarian tumors and 2 of 25 (8%) malignant ovarian tumors. Using the 9 additional MSI markers, MSI was observed in 7 of 46 (15.2%) ovarian tumors, including 3 of 21 (14.3%) borderline ovarian tumors and 4 of 25 (16%) malignant ovarian tumors. There was no statistically significant difference between MSI and clinicopathological factors, including histology and stage, although there was a trend toward an increased incidence of MSI in the serous type. CONCLUSION: MSI was infrequent in ovarian tumors, including both borderline and malignant tumors. MSI was found to be uncommon in sporadic ovarian tumors, even by using additional MSI markers. The clinical significance of MSI is not strong in patients with sporadic ovarian tumors. SN - 0513-5796 UR - https://www.unboundmedicine.com/medline/citation/18452265/Clinical_significance_of_microsatellite_instability_in_sporadic_epithelial_ovarian_tumors_ L2 - https://www.eymj.org/DOIx.php?id=10.3349/ymj.2008.49.2.272 DB - PRIME DP - Unbound Medicine ER -