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Dengue fever outbreak: a clinical management experience.
J Coll Physicians Surg Pak. 2008 Jan; 18(1):8-12.JC

Abstract

OBJECTIVE

To determine the frequency of dengue as a cause of fever and compare the clinical and haematological characteristics of Dengue-probable and Dengue-proven cases.

STUDY DESIGN

An observational study.

PLACE AND DURATION OF STUDY

The Combined Military Hospital, Malir Cantt., Karachi, from August 2005 to December 2006.

PATIENTS AND METHODS

All patients with age above 14 years, who were either hospitalized or treated in medical outdoor clinic due to acute febrile illness, were evaluated for clinical features of Dengue Fever (DF), Dengue haemorrhagic fever (DHF) and Dengue Shock Syndrome (DSS). Patients showing typical clinical features and haematological findings suggestive of Dengue fever (As per WHO criteria) were evaluated in detail for comparison of probable and confirmed cases of Dengue fever. All other cases of acute febrile illness, not showing clinical features or haematological abnormalities of Dengue fever, were excluded. The clinical and laboratory features were recorded on SPSS 11.0 programme and graded where required, for descriptive and statistical analysis.

RESULTS

Out of 5200 patients with febrile illness, 107(2%) presented with typical features of DF, 40/107(37%) were Dengue-proven while 67/107(63%) were Dengue-probable. Out of Dengue-proven cases, 38 were of DF and 2 were of DHF. Day 1 temperature ranged from 99-1050C (mean 1010C). Chills and rigors were noticed in 86 (80%), myalgia in 67%, headache in 54%, pharyngitis in 35%, rash in 28%, and bleeding manifestations in 2% cases. Hepatomegaly in 1(0.5%), lymphadenopathy in 1(0.5%) and splenomegaly in 12 (11.2%) cases. Leucopoenia (count<4x109 /L) was noted in 73%, platelet count<150 x109 /L in 84% and ALT>40 U/L in 57% cases.

CONCLUSION

Frequency of clinically suspected dengue virus infection was 107 (2%), while confirmed dengue fever cases were 40 (0.8%) out of 5200 fever cases. Fever with chills and rigors, body aches, headache, myalgia, rash, haemorrhagic manifestations, platelet count, total leukocyte count, and ALT, are parameters to screen the cases of suspected dengue virus infection; the diagnosis cannot be confirmed unless supported by molecular studies or dengue specific IgM .

Authors+Show Affiliations

Department of Medicine, Combined Military Hospital, Malir Cantt., Karachi, Pakistan. shahidahmed833@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

18452660

Citation

Ahmed, Shahid, et al. "Dengue Fever Outbreak: a Clinical Management Experience." Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, vol. 18, no. 1, 2008, pp. 8-12.
Ahmed S, Ali N, Ashraf S, et al. Dengue fever outbreak: a clinical management experience. J Coll Physicians Surg Pak. 2008;18(1):8-12.
Ahmed, S., Ali, N., Ashraf, S., Ilyas, M., Tariq, W. U., & Chotani, R. A. (2008). Dengue fever outbreak: a clinical management experience. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 18(1), 8-12. https://doi.org/01.2008/JCPSP.0812
Ahmed S, et al. Dengue Fever Outbreak: a Clinical Management Experience. J Coll Physicians Surg Pak. 2008;18(1):8-12. PubMed PMID: 18452660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dengue fever outbreak: a clinical management experience. AU - Ahmed,Shahid, AU - Ali,Nadir, AU - Ashraf,Shahzad, AU - Ilyas,Mohammad, AU - Tariq,Waheed-Uz-Zaman, AU - Chotani,Rashid A, PY - 2007/03/19/received PY - 2007/12/29/accepted PY - 2008/5/3/pubmed PY - 2008/7/8/medline PY - 2008/5/3/entrez SP - 8 EP - 12 JF - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP JO - J Coll Physicians Surg Pak VL - 18 IS - 1 N2 - OBJECTIVE: To determine the frequency of dengue as a cause of fever and compare the clinical and haematological characteristics of Dengue-probable and Dengue-proven cases. STUDY DESIGN: An observational study. PLACE AND DURATION OF STUDY: The Combined Military Hospital, Malir Cantt., Karachi, from August 2005 to December 2006. PATIENTS AND METHODS: All patients with age above 14 years, who were either hospitalized or treated in medical outdoor clinic due to acute febrile illness, were evaluated for clinical features of Dengue Fever (DF), Dengue haemorrhagic fever (DHF) and Dengue Shock Syndrome (DSS). Patients showing typical clinical features and haematological findings suggestive of Dengue fever (As per WHO criteria) were evaluated in detail for comparison of probable and confirmed cases of Dengue fever. All other cases of acute febrile illness, not showing clinical features or haematological abnormalities of Dengue fever, were excluded. The clinical and laboratory features were recorded on SPSS 11.0 programme and graded where required, for descriptive and statistical analysis. RESULTS: Out of 5200 patients with febrile illness, 107(2%) presented with typical features of DF, 40/107(37%) were Dengue-proven while 67/107(63%) were Dengue-probable. Out of Dengue-proven cases, 38 were of DF and 2 were of DHF. Day 1 temperature ranged from 99-1050C (mean 1010C). Chills and rigors were noticed in 86 (80%), myalgia in 67%, headache in 54%, pharyngitis in 35%, rash in 28%, and bleeding manifestations in 2% cases. Hepatomegaly in 1(0.5%), lymphadenopathy in 1(0.5%) and splenomegaly in 12 (11.2%) cases. Leucopoenia (count<4x109 /L) was noted in 73%, platelet count<150 x109 /L in 84% and ALT>40 U/L in 57% cases. CONCLUSION: Frequency of clinically suspected dengue virus infection was 107 (2%), while confirmed dengue fever cases were 40 (0.8%) out of 5200 fever cases. Fever with chills and rigors, body aches, headache, myalgia, rash, haemorrhagic manifestations, platelet count, total leukocyte count, and ALT, are parameters to screen the cases of suspected dengue virus infection; the diagnosis cannot be confirmed unless supported by molecular studies or dengue specific IgM . SN - 1022-386X UR - https://www.unboundmedicine.com/medline/citation/18452660/Dengue_fever_outbreak:_a_clinical_management_experience_ L2 - http://www.diseaseinfosearch.org/result/2187 DB - PRIME DP - Unbound Medicine ER -