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Lessons from the skin--cutaneous features of familial cancer.
Lancet Oncol 2008; 9(5):462-72LO

Abstract

As the molecular basis of disease continues to be elucidated, familial cancer syndromes, which consist of a range of neoplastic and non-neoplastic features, are emerging. The usual pathway of referral to a genetics clinic or familial cancer centre is via an oncologist, when high-risk features that suggest a possible hereditary basis for the presenting cancer are recognised. Traditionally, these high-risk features include more than two family members with similar cancers over two or more generations, a young age of onset, and more than one synchronous or metachronous tumour. These features are effective in ascertaining a substantial proportion of families with hereditary breast and ovarian cancer due to a BRCA mutation, or the more common bowel-cancer predisposition syndromes, such as hereditary non-polyposis colon cancer and familial adenomatous polyposis. However, there are a range of familial cancer syndromes that are not easily detected and that can remain undiagnosed when history and examination are not extended to include non-malignant features. The identification of cutaneous signs associated with rare familial-cancer syndromes provides individuals and their families with the opportunity to undertake early surveillance for malignant and non-malignant complications that might in time be shown to improve outcomes.

Authors+Show Affiliations

Department of Medicine, University of Melbourne, Royal Melbourne Hospital, VIC, Australia. Ingrid.Winship@mh.org.auNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18452857

Citation

Winship, Ingrid M., and Tracy E. Dudding. "Lessons From the Skin--cutaneous Features of Familial Cancer." The Lancet. Oncology, vol. 9, no. 5, 2008, pp. 462-72.
Winship IM, Dudding TE. Lessons from the skin--cutaneous features of familial cancer. Lancet Oncol. 2008;9(5):462-72.
Winship, I. M., & Dudding, T. E. (2008). Lessons from the skin--cutaneous features of familial cancer. The Lancet. Oncology, 9(5), pp. 462-72. doi:10.1016/S1470-2045(08)70126-8.
Winship IM, Dudding TE. Lessons From the Skin--cutaneous Features of Familial Cancer. Lancet Oncol. 2008;9(5):462-72. PubMed PMID: 18452857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lessons from the skin--cutaneous features of familial cancer. AU - Winship,Ingrid M, AU - Dudding,Tracy E, PY - 2008/5/3/pubmed PY - 2008/5/16/medline PY - 2008/5/3/entrez SP - 462 EP - 72 JF - The Lancet. Oncology JO - Lancet Oncol. VL - 9 IS - 5 N2 - As the molecular basis of disease continues to be elucidated, familial cancer syndromes, which consist of a range of neoplastic and non-neoplastic features, are emerging. The usual pathway of referral to a genetics clinic or familial cancer centre is via an oncologist, when high-risk features that suggest a possible hereditary basis for the presenting cancer are recognised. Traditionally, these high-risk features include more than two family members with similar cancers over two or more generations, a young age of onset, and more than one synchronous or metachronous tumour. These features are effective in ascertaining a substantial proportion of families with hereditary breast and ovarian cancer due to a BRCA mutation, or the more common bowel-cancer predisposition syndromes, such as hereditary non-polyposis colon cancer and familial adenomatous polyposis. However, there are a range of familial cancer syndromes that are not easily detected and that can remain undiagnosed when history and examination are not extended to include non-malignant features. The identification of cutaneous signs associated with rare familial-cancer syndromes provides individuals and their families with the opportunity to undertake early surveillance for malignant and non-malignant complications that might in time be shown to improve outcomes. SN - 1474-5488 UR - https://www.unboundmedicine.com/medline/citation/18452857/Lessons_from_the_skin__cutaneous_features_of_familial_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1470-2045(08)70126-8 DB - PRIME DP - Unbound Medicine ER -