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Apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats is increased by histidine and decreased by histidine decarboxylase, histamine H1 and H2 receptor antagonists, and an H3 receptor agonist.
Pharmacol Biochem Behav. 2008 Sep; 90(3):325-30.PB

Abstract

The role of histamine and its receptors in basal ganglia neurocircuitry was assessed in apomorphine-induced turning behavior. Rats with unilateral 6-hydroxydopamine lesions of the substantia nigra pars compacta and medial forebrain bundle were administered histaminergic agents, and apomorphine-induced turning behavior was tested on Days 7 and 14 post-lesion. Compared with saline-treated rats, histidine (500 mg/kg, i.p.), a precursor of histamine, increased turning behavior (p<0.05), while alpha-fluoromethylhistidine (alpha-FMH, 25 microg, i.c.v.), an irreversible inhibitor of histidine decarboxylase, decreased turning behavior (p<0.05) but only on Day 14 post-lesion. Both the histamine H(1) receptor antagonist pyrilamine (10 and 50 microg, i.c.v.) and the H(2) receptor antagonist cimetidine (10 and 50 microg, i.c.v.) significantly decreased turning behavior on Days 7 and 14 post-lesion. The histamine H(3) receptor agonist immepip (10 microg, i.c.v.) decreased turning behavior (p<0.05) on Day 14 post-lesion. The present findings indicate the complex interactions of histamine on basal ganglia function.

Authors+Show Affiliations

Department of Neurobiology, Institute of Neuroscience, Zhejiang University, School of Medicine, Hangzhou, 310058, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18452981

Citation

Liu, Chun-Qing, et al. "Apomorphine-induced Turning Behavior in 6-hydroxydopamine Lesioned Rats Is Increased By Histidine and Decreased By Histidine Decarboxylase, Histamine H1 and H2 Receptor Antagonists, and an H3 Receptor Agonist." Pharmacology, Biochemistry, and Behavior, vol. 90, no. 3, 2008, pp. 325-30.
Liu CQ, Hu DN, Liu FX, et al. Apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats is increased by histidine and decreased by histidine decarboxylase, histamine H1 and H2 receptor antagonists, and an H3 receptor agonist. Pharmacol Biochem Behav. 2008;90(3):325-30.
Liu, C. Q., Hu, D. N., Liu, F. X., Chen, Z., & Luo, J. H. (2008). Apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats is increased by histidine and decreased by histidine decarboxylase, histamine H1 and H2 receptor antagonists, and an H3 receptor agonist. Pharmacology, Biochemistry, and Behavior, 90(3), 325-30. https://doi.org/10.1016/j.pbb.2008.03.010
Liu CQ, et al. Apomorphine-induced Turning Behavior in 6-hydroxydopamine Lesioned Rats Is Increased By Histidine and Decreased By Histidine Decarboxylase, Histamine H1 and H2 Receptor Antagonists, and an H3 Receptor Agonist. Pharmacol Biochem Behav. 2008;90(3):325-30. PubMed PMID: 18452981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats is increased by histidine and decreased by histidine decarboxylase, histamine H1 and H2 receptor antagonists, and an H3 receptor agonist. AU - Liu,Chun-Qing, AU - Hu,Dan-Na, AU - Liu,Fu-Xin, AU - Chen,Zhong, AU - Luo,Jian-Hong, Y1 - 2008/03/25/ PY - 2008/03/01/received PY - 2008/03/10/accepted PY - 2008/5/3/pubmed PY - 2008/8/30/medline PY - 2008/5/3/entrez SP - 325 EP - 30 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 90 IS - 3 N2 - The role of histamine and its receptors in basal ganglia neurocircuitry was assessed in apomorphine-induced turning behavior. Rats with unilateral 6-hydroxydopamine lesions of the substantia nigra pars compacta and medial forebrain bundle were administered histaminergic agents, and apomorphine-induced turning behavior was tested on Days 7 and 14 post-lesion. Compared with saline-treated rats, histidine (500 mg/kg, i.p.), a precursor of histamine, increased turning behavior (p<0.05), while alpha-fluoromethylhistidine (alpha-FMH, 25 microg, i.c.v.), an irreversible inhibitor of histidine decarboxylase, decreased turning behavior (p<0.05) but only on Day 14 post-lesion. Both the histamine H(1) receptor antagonist pyrilamine (10 and 50 microg, i.c.v.) and the H(2) receptor antagonist cimetidine (10 and 50 microg, i.c.v.) significantly decreased turning behavior on Days 7 and 14 post-lesion. The histamine H(3) receptor agonist immepip (10 microg, i.c.v.) decreased turning behavior (p<0.05) on Day 14 post-lesion. The present findings indicate the complex interactions of histamine on basal ganglia function. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/18452981/Apomorphine_induced_turning_behavior_in_6_hydroxydopamine_lesioned_rats_is_increased_by_histidine_and_decreased_by_histidine_decarboxylase_histamine_H1_and_H2_receptor_antagonists_and_an_H3_receptor_agonist_ DB - PRIME DP - Unbound Medicine ER -