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Serum asymmetric dimethylarginine levels among Turks: association with metabolic syndrome in women and tendency to decrease in smokers.
Turk Kardiyol Dern Ars. 2008 Jan; 36(1):7-13.TK

Abstract

OBJECTIVES

We investigated serum asymmetric dimethylarginine (ADMA) levels and their association with smoking, metabolic syndrome (MS), and coronary heart disease (CHD) among Turkish adults.

STUDY DESIGN

Serum ADMA concentrations were measured in a cross-sectional study by a validated ELISA kit in a random sample of 464 Turkish adults (222 men, 242 women; mean age 55+/-11 years; range 34-89). Metabolic syndrome was identified by the criteria of the Adult Treatment Panel-III modified for male abdominal obesity.

RESULTS

The median serum ADMA concentration was 0.80 micromol/l, with the interquartile range of 0.57 to 1.13 micromol/l. Compared to nonsmokers, age-adjusted ADMA level was 20% lower in smoking men (p=0.057), and 6% lower in smoking women (p=0.6). Serum ADMA levels showed significant and positive correlations with age, testosterone, and fibrinogen concentrations in men, and a borderline significance with triglyceride, C-reactive protein, and sex hormone-binding globulin in women. No significant association was found with MS, hypertension, or CHD likelihood among men; but, after adjustment for age, smoking status, and systolic blood pressure, the odds ratio of doubling of ADMA for the likelihood of MS reached significance in women (OR 1.25; 95% CI 1.01; 1.53). Age- and smoking-adjusted ADMA in women tended to be associated also with hypertension (OR 2.55, p=0.07).

CONCLUSION

Serum ADMA levels are significantly associated with MS likelihood in women alone, but not with the likelihood for CHD in either gender. Serum ADMA in middle-aged and elderly Turks is inversely associated with cigarette smoking, and thus possibly contributes to the smoking-related protection of Turkish women from MS.

Authors+Show Affiliations

Department of Cardiology, Cerrahpaşa Medical Faculty of Istanbul University, Istanbul. alt_onat@yahoo.com.trNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18453780

Citation

Onat, Altan, et al. "Serum Asymmetric Dimethylarginine Levels Among Turks: Association With Metabolic Syndrome in Women and Tendency to Decrease in Smokers." Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir, vol. 36, no. 1, 2008, pp. 7-13.
Onat A, Hergenç G, Can G, et al. Serum asymmetric dimethylarginine levels among Turks: association with metabolic syndrome in women and tendency to decrease in smokers. Turk Kardiyol Dern Ars. 2008;36(1):7-13.
Onat, A., Hergenç, G., Can, G., & Karabulut, A. (2008). Serum asymmetric dimethylarginine levels among Turks: association with metabolic syndrome in women and tendency to decrease in smokers. Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir, 36(1), 7-13.
Onat A, et al. Serum Asymmetric Dimethylarginine Levels Among Turks: Association With Metabolic Syndrome in Women and Tendency to Decrease in Smokers. Turk Kardiyol Dern Ars. 2008;36(1):7-13. PubMed PMID: 18453780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum asymmetric dimethylarginine levels among Turks: association with metabolic syndrome in women and tendency to decrease in smokers. AU - Onat,Altan, AU - Hergenç,Gülay, AU - Can,Günay, AU - Karabulut,Ahmet, PY - 2008/5/6/pubmed PY - 2008/7/30/medline PY - 2008/5/6/entrez SP - 7 EP - 13 JF - Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir JO - Turk Kardiyol Dern Ars VL - 36 IS - 1 N2 - OBJECTIVES: We investigated serum asymmetric dimethylarginine (ADMA) levels and their association with smoking, metabolic syndrome (MS), and coronary heart disease (CHD) among Turkish adults. STUDY DESIGN: Serum ADMA concentrations were measured in a cross-sectional study by a validated ELISA kit in a random sample of 464 Turkish adults (222 men, 242 women; mean age 55+/-11 years; range 34-89). Metabolic syndrome was identified by the criteria of the Adult Treatment Panel-III modified for male abdominal obesity. RESULTS: The median serum ADMA concentration was 0.80 micromol/l, with the interquartile range of 0.57 to 1.13 micromol/l. Compared to nonsmokers, age-adjusted ADMA level was 20% lower in smoking men (p=0.057), and 6% lower in smoking women (p=0.6). Serum ADMA levels showed significant and positive correlations with age, testosterone, and fibrinogen concentrations in men, and a borderline significance with triglyceride, C-reactive protein, and sex hormone-binding globulin in women. No significant association was found with MS, hypertension, or CHD likelihood among men; but, after adjustment for age, smoking status, and systolic blood pressure, the odds ratio of doubling of ADMA for the likelihood of MS reached significance in women (OR 1.25; 95% CI 1.01; 1.53). Age- and smoking-adjusted ADMA in women tended to be associated also with hypertension (OR 2.55, p=0.07). CONCLUSION: Serum ADMA levels are significantly associated with MS likelihood in women alone, but not with the likelihood for CHD in either gender. Serum ADMA in middle-aged and elderly Turks is inversely associated with cigarette smoking, and thus possibly contributes to the smoking-related protection of Turkish women from MS. SN - 1016-5169 UR - https://www.unboundmedicine.com/medline/citation/18453780/Serum_asymmetric_dimethylarginine_levels_among_Turks:_association_with_metabolic_syndrome_in_women_and_tendency_to_decrease_in_smokers_ L2 - https://www.journalagent.com/pubmed/linkout.asp?ISSN=1016-5169&PMID=18453780 DB - PRIME DP - Unbound Medicine ER -