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Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms.
Nutr Rev. 2008 May; 66(5):250-5.NR

Abstract

Severe vitamin B(12) deficiency produces a cluster of neurological symptoms in infants, including irritability, failure to thrive, apathy, anorexia, and developmental regression, which respond remarkably rapidly to supplementation. The underlying mechanisms may involve delayed myelination or demyelination of nerves; alteration in the S-adenosylmethionine:S-adenosylhomocysteine ratio; imbalance of neurotrophic and neurotoxic cytokines; and/or accumulation of lactate in brain cells. This review summarizes the current knowledge concerning infantile vitamin B(12) deficiency, including a pooled analysis of case studies of infants born to mothers with untreated pernicious anemia or a strict vegetarian lifestyle and a discussion of the mechanisms that may underlie the manifestations of deficiency.

Authors+Show Affiliations

Department of Nutrition at the University of California Davis, Davis, California, USA. dkdror@ucdavis.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18454811

Citation

Dror, Daphna K., and Lindsay H. Allen. "Effect of Vitamin B12 Deficiency On Neurodevelopment in Infants: Current Knowledge and Possible Mechanisms." Nutrition Reviews, vol. 66, no. 5, 2008, pp. 250-5.
Dror DK, Allen LH. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutr Rev. 2008;66(5):250-5.
Dror, D. K., & Allen, L. H. (2008). Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutrition Reviews, 66(5), 250-5. https://doi.org/10.1111/j.1753-4887.2008.00031.x
Dror DK, Allen LH. Effect of Vitamin B12 Deficiency On Neurodevelopment in Infants: Current Knowledge and Possible Mechanisms. Nutr Rev. 2008;66(5):250-5. PubMed PMID: 18454811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. AU - Dror,Daphna K, AU - Allen,Lindsay H, PY - 2008/5/6/pubmed PY - 2008/7/9/medline PY - 2008/5/6/entrez SP - 250 EP - 5 JF - Nutrition reviews JO - Nutr Rev VL - 66 IS - 5 N2 - Severe vitamin B(12) deficiency produces a cluster of neurological symptoms in infants, including irritability, failure to thrive, apathy, anorexia, and developmental regression, which respond remarkably rapidly to supplementation. The underlying mechanisms may involve delayed myelination or demyelination of nerves; alteration in the S-adenosylmethionine:S-adenosylhomocysteine ratio; imbalance of neurotrophic and neurotoxic cytokines; and/or accumulation of lactate in brain cells. This review summarizes the current knowledge concerning infantile vitamin B(12) deficiency, including a pooled analysis of case studies of infants born to mothers with untreated pernicious anemia or a strict vegetarian lifestyle and a discussion of the mechanisms that may underlie the manifestations of deficiency. SN - 0029-6643 UR - https://www.unboundmedicine.com/medline/citation/18454811/Effect_of_vitamin_B12_deficiency_on_neurodevelopment_in_infants:_current_knowledge_and_possible_mechanisms_ L2 - https://academic.oup.com/nutritionreviews/article-lookup/doi/10.1111/j.1753-4887.2008.00031.x DB - PRIME DP - Unbound Medicine ER -