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Synergistic effect of high lactase activity genotype and galactose-1-phosphate uridyl transferase (GALT) mutations on idiopathic presenile cataract formation.

Abstract

OBJECTIVES

To evaluate the possible synergistic role of partial galactose metabolism defects, high lactase (LPH) genotype and lactose and galactose ingestion in presenile cataract formation.

DESIGN AND METHODS

51 patients with idiopathic presenile cataracts and 172 healthy cataract-free subjects were genotyped to determine their galactose-1-phosphate uridyl transferase (GALT) and LPH status. Whole milk, skimmed milk and yoghurt consumption was recorded in 19 cataract patients and 172 controls by questionnaire.

RESULTS

GALT mutations and whole milk consumption increased the risk of cataract formation in high LPH genotype group, but not in lactose intolerant subjects. Logistic regression analysis showed the synergistic effect of GALT and LPH mutations on cataract formation.

CONCLUSIONS

High lactase activity genotypes and mutations in galactose-1-phosphate uridyl transferase have a synergistic effect on presenile cataract formation.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Faculty of Pharmacy, University of Ljubljana, Slovenia. natasa.karas@ffa.uni-lj.si

    ,

    Source

    Clinical biochemistry 41:10-11 2008 Jul pg 869-74

    MeSH

    Adult
    Age of Onset
    Blood Glucose
    Cataract
    Cholesterol
    Diabetes Mellitus
    Female
    Genotype
    Humans
    Lactase
    Male
    Middle Aged
    Mutation
    Reference Values
    UTP-Hexose-1-Phosphate Uridylyltransferase

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18454942

    Citation

    Karas-Kuzelicki, Natasa, et al. "Synergistic Effect of High Lactase Activity Genotype and Galactose-1-phosphate Uridyl Transferase (GALT) Mutations On Idiopathic Presenile Cataract Formation." Clinical Biochemistry, vol. 41, no. 10-11, 2008, pp. 869-74.
    Karas-Kuzelicki N, Pfeifer V, Lukac-Bajalo J. Synergistic effect of high lactase activity genotype and galactose-1-phosphate uridyl transferase (GALT) mutations on idiopathic presenile cataract formation. Clin Biochem. 2008;41(10-11):869-74.
    Karas-Kuzelicki, N., Pfeifer, V., & Lukac-Bajalo, J. (2008). Synergistic effect of high lactase activity genotype and galactose-1-phosphate uridyl transferase (GALT) mutations on idiopathic presenile cataract formation. Clinical Biochemistry, 41(10-11), pp. 869-74. doi:10.1016/j.clinbiochem.2008.04.002.
    Karas-Kuzelicki N, Pfeifer V, Lukac-Bajalo J. Synergistic Effect of High Lactase Activity Genotype and Galactose-1-phosphate Uridyl Transferase (GALT) Mutations On Idiopathic Presenile Cataract Formation. Clin Biochem. 2008;41(10-11):869-74. PubMed PMID: 18454942.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Synergistic effect of high lactase activity genotype and galactose-1-phosphate uridyl transferase (GALT) mutations on idiopathic presenile cataract formation. AU - Karas-Kuzelicki,Natasa, AU - Pfeifer,Vladimir, AU - Lukac-Bajalo,Jana, Y1 - 2008/04/18/ PY - 2007/12/07/received PY - 2008/02/05/revised PY - 2008/04/03/accepted PY - 2008/5/6/pubmed PY - 2008/8/7/medline PY - 2008/5/6/entrez SP - 869 EP - 74 JF - Clinical biochemistry JO - Clin. Biochem. VL - 41 IS - 10-11 N2 - OBJECTIVES: To evaluate the possible synergistic role of partial galactose metabolism defects, high lactase (LPH) genotype and lactose and galactose ingestion in presenile cataract formation. DESIGN AND METHODS: 51 patients with idiopathic presenile cataracts and 172 healthy cataract-free subjects were genotyped to determine their galactose-1-phosphate uridyl transferase (GALT) and LPH status. Whole milk, skimmed milk and yoghurt consumption was recorded in 19 cataract patients and 172 controls by questionnaire. RESULTS: GALT mutations and whole milk consumption increased the risk of cataract formation in high LPH genotype group, but not in lactose intolerant subjects. Logistic regression analysis showed the synergistic effect of GALT and LPH mutations on cataract formation. CONCLUSIONS: High lactase activity genotypes and mutations in galactose-1-phosphate uridyl transferase have a synergistic effect on presenile cataract formation. SN - 1873-2933 UR - https://www.unboundmedicine.com/medline/citation/18454942/Synergistic_effect_of_high_lactase_activity_genotype_and_galactose_1_phosphate_uridyl_transferase__GALT__mutations_on_idiopathic_presenile_cataract_formation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(08)00155-0 DB - PRIME DP - Unbound Medicine ER -